RIOX2

RIOX2

Identifiers

RIOX2, MDIG, MINA53, NO52, ROX, MINA, MYC-induced nuclear antigen, MYC induced nuclear antigen, ribosomal oxygenase 2, JMJD10

External IDs

OMIM: 612049; MGI: 1914264; GeneCards: RIOX2

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2XDV, 4BU2, 4BXF

Enzyme activity
EC #	BRENDA	ExPASy	KEGG	MetaCyc
1.14.11.79	↗	↗	↗	↗

Gene location (Human)

Chr.	Chromosome 3 (human)

Band	3q11.2	Start	97,941,818 bp
Band	3q11.2	End	97,972,457 bp

Gene location (Mouse)

Chr.	Chromosome 16 (mouse)

Band	16\|16 C1.3	Start	59,292,138 bp
Band	16\|16 C1.3	End	59,312,824 bp

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

secondary oocyte

right lobe of thyroid gland

left lobe of thyroid gland

oral cavity

buccal mucosa cell

internal globus pallidus

parotid gland

body of pancreas

tendon of biceps brachii

Skeletal muscle tissue of rectus abdominis

Top expressed in

otic placode

saccule

otic vesicle

primitive streak

epiblast

sternocleidomastoid muscle

temporal muscle

digastric muscle

embryo

right kidney

More reference expression data


More reference expression data

Gene ontology
Molecular function	oxidoreductase activity dioxygenase activity metal ion binding histone demethylase activity identical protein binding histone H3-methyl-lysine-4 demethylase activity histone H3-methyl-lysine-36 demethylase activity transcription corepressor activity
Cellular component	nucleolus transcription regulator complex nucleus nucleoplasm cytosol
Biological process	regulation of transcription, DNA-templated negative regulation of transcription by RNA polymerase II transcription, DNA-templated negative regulation of transcription, DNA-templated histone demethylation chromatin remodeling peptidyl-arginine hydroxylation histone H3-K4 demethylation ribosome biogenesis histone H3-K36 demethylation negative regulation of nucleic acid-templated transcription
Sources:Amigo / QuickGO

Databases

NCBI: entry; OMA: entry

Species

Human

Mouse


84864


67014


ENSG00000170854


ENSMUSG00000022724


Q8IUF8


Q8CD15

RefSeq (mRNA)


NM_001042533 NM_001261829 NM_032778 NM_153182


NM_025910

RefSeq (protein)


NP_001035998 NP_001248758 NP_116167 NP_694822


NP_080186

Location (UCSC)

Chr 3: 97.94 – 97.97 Mb

Chr 16: 59.29 – 59.31 Mb

PubMed search

View/Edit Human

View/Edit Mouse

Ribosomal oxygenase 2 is a protein that in humans is encoded by the RIOX2 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000170854 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000022724 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Tsuneoka M, Koda Y, Soejima M, Teye K, Kimura H (Sep 2002). "A novel myc target gene, mina53, that is involved in cell proliferation". J Biol Chem. 277 (38): 35450–9. doi:10.1074/jbc.M204458200. PMID 12091391.
↑ "Entrez Gene: MINA MYC induced nuclear antigen".

Further reading

Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Teye K, Tsuneoka M, Arima N, et al. (2004). "Increased Expression of a Myc Target Gene Mina53 in Human Colon Cancer". Am. J. Pathol. 164 (1): 205–16. doi:10.1016/S0002-9440(10)63111-2. PMC 1602225. PMID 14695334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Eilbracht J, Reichenzeller M, Hergt M, et al. (2004). "NO66, a Highly Conserved Dual Location Protein in the Nucleolus and in a Special Type of Synchronously Replicating Chromatin". Mol. Biol. Cell. 15 (4): 1816–32. doi:10.1091/mbc.E03-08-0623. PMC 379278. PMID 14742713.
Tsuneoka M, Fujita H, Arima N, et al. (2005). "Mina53 as a potential prognostic factor for esophageal squamous cell carcinoma". Clin. Cancer Res. 10 (21): 7347–56. doi:10.1158/1078-0432.CCR-03-0543. PMID 15534111.
Eilbracht J, Kneissel S, Hofmann A, Schmidt-Zachmann MS (2005). "Protein NO52--a constitutive nucleolar component sharing high sequence homologies to protein NO66". Eur. J. Cell Biol. 84 (2–3): 279–94. doi:10.1016/j.ejcb.2004.12.022. PMID 15819408.
Zhang Y, Lu Y, Yuan BZ, et al. (2005). "The Human mineral dust-induced gene, mdig, is a cell growth regulating gene associated with lung cancer". Oncogene. 24 (31): 4873–82. doi:10.1038/sj.onc.1208668. PMID 15897898. S2CID 24239327.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Teye K, Arima N, Nakamura Y, et al. (2007). "Expression of Myc target gene mina53 in subtypes of human lymphoma". Oncol. Rep. 18 (4): 841–8. doi:10.3892/or.18.4.841. PMID 17786344.
Ishizaki H, Yano H, Tsuneoka M, et al. (2007). "Overexpression of the myc target gene Mina53 in advanced renal cell carcinoma". Pathol. Int. 57 (10): 672–80. doi:10.1111/j.1440-1827.2007.02156.x. PMID 17803656. S2CID 20991987.

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