RNA-binding protein RO60

RO60
Identifiers
Aliases	RO60, RORNP, SSA2, TROVE domain family member 2, Ro60, Y RNA binding protein, TROVE2
External IDs	OMIM: 600063; MGI: 106652; GeneCards: RO60
Gene location (Human)
Chr.	Chromosome 1 (human)
End	193,091,777 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	143,652,806 bp
RNA expression pattern
	Top expressed in
	nipple; ; external globus pallidus; ; dorsal motor nucleus of vagus nerve; ; inferior ganglion of vagus nerve; ; inferior olivary nucleus; ; optic nerve; ; sperm; ; pars reticulata; ; renal medulla; ; trabecular bone;
	Top expressed in
	superior surface of tongue; ; gallbladder; ; Rostral migratory stream; ; molar; ; cerebellar vermis; ; pineal gland; ; lobe of cerebellum; ; trigeminal ganglion; ; cingulate gyrus; ; habenula;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	U2 snRNA binding; metal ion binding; RNA binding;
Cellular component	nucleus; cytoplasm; nucleoplasm; cytosol; ribonucleoprotein complex;
Biological process	immune system development; transcription by RNA polymerase III; smoothened signaling pathway; response to UV; cilium assembly; cell projection organization; regulation of gene expression; cellular response to interferon-alpha;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	6738
	20822
	ENSG00000116747
	ENSMUSG00000018199
	P10155
	O08848
NM_001042369; NM_001042370; NM_001173524; NM_001173525; NM_004600;
	NM_001331020
	NM_013835
NP_001035828; NP_001035829; NP_001166995; NP_001166996; NP_001317949;
	NP_004591
	NP_038863
	Wikidata
View/Edit Human	View/Edit Mouse

RNA-binding protein RO60 is a protein that in humans is encoded by the RO60 gene (previously TROVE2). This protein binds to and regulates various types of RNA molecules like Y RNA and pre-5S ribosomal RNA. This includes problematic RNA like misfolded RNA and inflammation-induced Alu retrotransposon elements.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000116747 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000018199 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Frank MB, Mattei MG (Jun 1994). "Mapping of the human 60,000 M(r) Ro/SSA locus: the genes for three Ro/SSA autoantigens are located on separate chromosomes". Immunogenetics. 39 (6): 428–31. doi:10.1007/bf00176161. PMID 8188321. S2CID 9772708.
↑ "Entrez Gene: TROVE2 TROVE domain family, member 2".
1 2 "RNA-binding protein RO60". uniprot.org. UniProt consortium. Retrieved 2026-09-13.

James JA, Dickey WD, Fujisaku A, et al. (1990). "Antigenicity of a recombinant Ro (SS-A) fusion protein". Arthritis Rheum. 33 (1): 102–6. doi:10.1002/art.1780330114. PMID 1689160.
Jitsukawa T, Nakajima S, Usui J, Watanabe H (1991). "Detection of anti-nuclear antibodies from patients with systemic rheumatic diseases by ELISA using HEp-2 cell nuclei". J. Clin. Lab. Anal. 5 (1): 49–53. doi:10.1002/jcla.1860050109. PMID 1999763. S2CID 25495352.
Ben-Chetrit E, Gandy BJ, Tan EM, Sullivan KF (1989). "Isolation and characterization of a cDNA clone encoding the 60-kD component of the human SS-A/Ro ribonucleoprotein autoantigen". J. Clin. Invest. 83 (4): 1284–92. doi:10.1172/JCI114013. PMC 303819. PMID 2649513.
Deutscher SL, Harley JB, Keene JD (1989). "Molecular analysis of the 60-kDa human Ro ribonucleoprotein". Proc. Natl. Acad. Sci. U.S.A. 85 (24): 9479–83. doi:10.1073/pnas.85.24.9479. PMC 282776. PMID 3200833.
Lee LA, Harmon CE, Huff JC, et al. (1985). "The demonstration of SS-A/Ro antigen in human fetal tissues and in neonatal and adult skin". J. Invest. Dermatol. 85 (2): 143–6. doi:10.1111/1523-1747.ep12276566. PMID 3926904.
Wolin SL, Steitz JA (1984). "The Ro small cytoplasmic ribonucleoproteins: identification of the antigenic protein and its binding site on the Ro RNAs". Proc. Natl. Acad. Sci. U.S.A. 81 (7): 1996–2000. Bibcode:1984PNAS...81.1996W. doi:10.1073/pnas.81.7.1996. PMC 345423. PMID 6201849.
Harmon CE, Deng JS, Peebles CL, Tan EM (1984). "The importance of tissue substrate in the SS-A/Ro antigen-antibody system". Arthritis Rheum. 27 (2): 166–73. doi:10.1002/art.1780270207. PMID 6421292.
Fritzler MJ, Miller BJ (1995). "Detection of autoantibodies to SS-A/Ro by indirect immunofluorescence using a transfected and overexpressed human 60 kD Ro autoantigen in HEp-2 cells". J. Clin. Lab. Anal. 9 (3): 218–24. doi:10.1002/jcla.1860090312. PMID 7602431. S2CID 39372814.
Chan EK, Tan EM, Ward DC, Matera AG (1995). "Human 60-kDa SS-A/Ro ribonucleoprotein autoantigen gene (SSA2) localized to 1q31 by fluorescence in situ hybridization". Genomics. 23 (1): 298–300. doi:10.1006/geno.1994.1502. PMID 7829096.
Wang D, Buyon JP, Zhu W, Chan EK (1999). "Defining a novel 75-kDa phosphoprotein associated with SS-A/Ro and identification of distinct human autoantibodies". J. Clin. Invest. 104 (9): 1265–75. doi:10.1172/JCI8003. PMC 409828. PMID 10545525.
Kurien BT, Chambers TL, Thomas PY, et al. (2001). "Autoantibody to the leucine zipper region of 52 kDa Ro/SSA binds native 60 kDa Ro/SSA: identification of a tertiary epitope with components from 60 kDa Ro/SSA and 52 kDa Ro/SSA". Scand. J. Immunol. 53 (3): 268–76. doi:10.1046/j.1365-3083.2001.00870.x. PMID 11251884.
Fouraux MA, Bouvet P, Verkaart S, et al. (2002). "Nucleolin associates with a subset of the human Ro ribonucleoprotein complexes". J. Mol. Biol. 320 (3): 475–88. doi:10.1016/S0022-2836(02)00518-1. hdl:2066/121576. PMID 12096904.
McArthur C, Wang Y, Veno P, et al. (2002). "Intracellular trafficking and surface expression of SS-A (Ro), SS-B (La), poly(ADP-ribose) polymerase and alpha-fodrin autoantigens during apoptosis in human salivary gland cells induced by tumour necrosis factor-alpha". Arch. Oral Biol. 47 (6): 443–8. doi:10.1016/S0003-9969(02)00025-0. PMID 12102760.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Belisova A, Semrad K, Mayer O, et al. (2005). "RNA chaperone activity of protein components of human Ro RNPs". RNA. 11 (7): 1084–94. doi:10.1261/rna.7263905. PMC 1370793. PMID 15928345.
Hennig J, Ottosson L, Andrésen C, et al. (2005). "Structural organization and Zn2+-dependent subdomain interactions involving autoantigenic epitopes in the Ring-B-box-coiled-coil (RBCC) region of Ro52". J. Biol. Chem. 280 (39): 33250–61. doi:10.1074/jbc.M503066200. PMID 15964842.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
"Scientists Find Link between Immune System, Memory and Structure of Brain | Genetics, Neuroscience | Sci-News.com". Breaking Science News | Sci-News.com. Retrieved 2017-05-01.

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000116747 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000018199 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8188321-5] Frank MB, Mattei MG (Jun 1994). "Mapping of the human 60,000 M(r) Ro/SSA locus: the genes for three Ro/SSA autoantigens are located on separate chromosomes". Immunogenetics. 39 (6): 428–31. doi:10.1007/bf00176161. PMID 8188321. S2CID 9772708.

[entrez-6] "Entrez Gene: TROVE2 TROVE domain family, member 2".

[uniprot-7] 1 2 "RNA-binding protein RO60". uniprot.org. UniProt consortium. Retrieved 2026-09-13.

RNA-binding protein RO60

See also

References

Further reading