RNF10

RNF10
Identifiers
Aliases	RNF10, RIE2, ring finger protein 10
External IDs	OMIM: 615998; MGI: 1859162; GeneCards: RNF10
Enzyme activity
Gene location (Human)
Chr.	Chromosome 12 (human)
End	120,577,588 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	115,410,957 bp
RNA expression pattern
	Top expressed in
	left testis; ; right testis; ; muscle of thigh; ; gastrocnemius muscle; ; sural nerve; ; stromal cell of endometrium; ; anterior pituitary; ; ventricular zone; ; epithelium of colon; ; blood;
	Top expressed in
	blood; ; neural layer of retina; ; entorhinal cortex; ; choroid plexus of fourth ventricle; ; lactiferous gland; ; perirhinal cortex; ; CA3 field; ; muscle of thigh; ; superior surface of tongue; ; dentate gyrus of hippocampal formation granule cell;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; protein binding; metal ion binding; ubiquitin-protein transferase activity;
Cellular component	cytoplasm; nucleus;
Biological process	positive regulation of transcription, DNA-templated; positive regulation of myelination; regulation of transcription, DNA-templated; transcription, DNA-templated; negative regulation of Schwann cell proliferation; positive regulation of transcription by RNA polymerase II; protein autoubiquitination;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	9921
	50849
	ENSG00000022840
	ENSMUSG00000041740
	Q8N5U6
	Q3UIW5
	NM_014868; NM_001330474
	NM_016698; NM_001302448; NM_001302449
	NP_001317403; NP_055683
	NP_001289377; NP_001289378; NP_057907
	Wikidata
View/Edit Human	View/Edit Mouse

RING finger protein 10 is a protein that in humans is encoded by the RNF10 gene.

Function

The protein encoded by this gene contains a ring finger motif, which is known to be involved in protein-protein interactions. The specific function of this protein has not yet been determined. EST data suggests the existence of multiple alternatively spliced transcript variants, however, their full length nature is not known.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000022840 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000041740 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 "Entrez Gene: RNF10 ring finger protein 10".

Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T (Jun 2002). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Research. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
Nagase T, Seki N, Ishikawa K, Ohira M, Kawarabayasi Y, Ohara O, Tanaka A, Kotani H, Miyajima N, Nomura N (Oct 1996). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain". DNA Research. 3 (5): 321–9, 341–54. doi:10.1093/dnares/3.5.321. PMID 9039502.
Seki N, Hattori A, Sugano S, Muramatsu M, Saito T (2000). "cDNA cloning, expression profile, and genomic structure of human and mouse RNF10/Rnf 10 genes, encoding a novel RING finger protein". Journal of Human Genetics. 45 (1): 38–42. doi:10.1007/s100380050007. PMID 10697961.
Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (Sep 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.
Lin J, Friesen MT, Bocangel P, Cheung D, Rawszer K, Wigle JT (Jul 2005). "Characterization of Mesenchyme Homeobox 2 (MEOX2) transcription factor binding to RING finger protein 10". Molecular and Cellular Biochemistry. 275 (1–2): 75–84. doi:10.1007/s11010-005-0823-3. PMID 16335786. S2CID 30515981.
Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (Jan 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000022840 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000041740 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] 1 2 "Entrez Gene: RNF10 ring finger protein 10".

RNF10

Function

References

Further reading