RNF41

RNF41
Identifiers
Aliases	RNF41, FLRF, NRDP1, SBBI03, ring finger protein 41
External IDs	MGI: 1914838; GeneCards: RNF41
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2FZP, 2GWF
Enzyme activity
Gene location (Human)
Chr.	Chromosome 12 (human)
End	56,221,933 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	128,277,310 bp
RNA expression pattern
	Top expressed in
	Brodmann area 10; ; paraflocculus of cerebellum; ; frontal pole; ; islet of Langerhans; ; monocyte; ; lateral nuclear group of thalamus; ; stromal cell of endometrium; ; gallbladder; ; right coronary artery; ; popliteal artery;
	Top expressed in
	seminiferous tubule; ; dentate gyrus of hippocampal formation granule cell; ; primary visual cortex; ; spermatid; ; superior frontal gyrus; ; ventricular zone; ; granulocyte; ; ganglionic eminence; ; Rostral migratory stream; ; cerebellar cortex;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	interleukin-3 receptor binding; erythropoietin receptor binding; zinc ion binding; metal ion binding; protein binding; transferase activity; ubiquitin-protein transferase activity; protein domain specific binding; receptor tyrosine kinase binding; ubiquitin protein ligase activity;
Cellular component	cytosol; perinuclear region of cytoplasm; endoplasmic reticulum tubular network;
Biological process	regulation of MAPK cascade; extrinsic apoptotic signaling pathway; positive regulation of DNA-binding transcription factor activity; protein polyubiquitination; regulation of reactive oxygen species metabolic process; autophagy; negative regulation of cell migration; regulation of lymphocyte differentiation; positive regulation of reactive oxygen species metabolic process; protein ubiquitination; regulation of protein kinase B signaling; regulation of gene expression; proteasomal protein catabolic process; regulation of myeloid cell differentiation; regulation of establishment of cell polarity; negative regulation of cell population proliferation; protein autoubiquitination; apoptotic process; negative regulation of mitophagy; positive regulation of protein catabolic process;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	10193
	67588
	ENSG00000181852
	ENSMUSG00000025373
	Q9H4P4
	Q8BH75
	NM_001242826; NM_005785; NM_194358; NM_194359
	NM_001164237; NM_026259
	NP_001229755; NP_005776; NP_919339; NP_919340
	NP_001157709; NP_080535
	Wikidata
View/Edit Human	View/Edit Mouse

E3 ubiquitin-protein ligase NRDP1 is an enzyme that in humans is encoded by the RNF41 gene.

Function

The protein encoded by this gene contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. The specific function of this protein has not yet been determined. Three alternatively spliced transcript variants encoding two distinct isoforms have been reported.