RPP14

RPP14

Identifiers

RPP14, P14, HsHTD2, ribonuclease P/MRP subunit p14

External IDs

OMIM: 606112; MGI: 1914303; GeneCards: RPP14

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
3IR3

Enzyme activity
EC #	BRENDA	ExPASy	KEGG	MetaCyc
4.2.1.59	↗	↗	↗	↗

Gene location (Human)

Chr.	Chromosome 3 (human)

Band	3p14.3	Start	58,306,245 bp
Band	3p14.3	End	58,324,695 bp

Gene location (Mouse)

Chr.	Chromosome 14 (mouse)

Band	14\|14 A1	Start	14,377,939 bp
Band	14\|14 A1	End	14,389,406 bp

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

muscle of thigh

gonad

gastrocnemius muscle

Achilles tendon

mucosa of transverse colon

stromal cell of endometrium

testicle

epithelium of colon

ventricular zone

smooth muscle tissue

Top expressed in

ventricular zone

seminal vesicula

embryo

embryo

morula

sternocleidomastoid muscle

epiblast

temporal muscle

triceps brachii muscle

facial motor nucleus

More reference expression data


More reference expression data

Gene ontology
Molecular function	ribonuclease activity hydrolase activity RNA binding ribonuclease P activity lyase activity 3-hydroxyacyl-CoA dehydratase activity
Cellular component	nucleus nucleoplasm multimeric ribonuclease P complex nucleolus mitochondrion mitochondrial matrix
Biological process	RNA phosphodiester bond hydrolysis RNA phosphodiester bond hydrolysis, endonucleolytic tRNA processing tRNA 5'-leader removal fatty acid metabolic process lipid metabolism fatty-acyl-CoA biosynthetic process
Sources:Amigo / QuickGO

Databases

NCBI: entry; OMA: entry

Species

Human

Mouse


11102


67053


ENSG00000163684


ENSMUSG00000023156


O95059 P86397


Q9CQH8

RefSeq (mRNA)


NM_001098783 NM_007042


NM_025938

RefSeq (protein)

NP_001092253 NP_008973 NP_001335641 NP_001335642 NP_001335643
NP_001335644


NP_080214

Location (UCSC)

Chr 3: 58.31 – 58.32 Mb

Chr 14: 14.38 – 14.39 Mb

PubMed search

View/Edit Human

View/Edit Mouse

Ribonuclease P protein subunit p14 is an enzyme that in humans is encoded by the RPP14 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000163684 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000023156 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Jarrous N, Eder PS, Wesolowski D, Altman S (Mar 1999). "Rpp14 and Rpp29, two protein subunits of human ribonuclease P". RNA. 5 (2): 153–157. doi:10.1017/S135583829800185X. PMC 1369747. PMID 10024167.
↑ Jiang T, Altman S (Apr 2002). "A protein subunit of human RNase P, Rpp14, and its interacting partner, OIP2, have 3'-->5' exoribonuclease activity". Proc Natl Acad Sci U S A. 99 (8): 5295–5300. doi:10.1073/pnas.072083699. PMC 122763. PMID 11929972.
↑ "Entrez Gene: RPP14 ribonuclease P 14kDa subunit".

Further reading

Jiang T, Altman S (2001). "Protein-protein interactions with subunits of human nuclear RNase P". Proc. Natl. Acad. Sci. U.S.A. 98 (3): 920–925. doi:10.1073/pnas.021561498. PMC 14685. PMID 11158571.
Venter JC, Adams MD, Myers EW, et al. (2001). "The sequence of the human genome". Science. 291 (5507): 1304–1351. Bibcode:2001Sci...291.1304V. doi:10.1126/science.1058040. PMID 11181995.
Jiang T, Guerrier-Takada C, Altman S (2001). "Protein-RNA interactions in the subunits of human nuclear RNase P". RNA. 7 (7): 937–941. doi:10.1017/S1355838201010299. PMC 1370153. PMID 11455963.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
Welting TJ, van Venrooij WJ, Pruijn GJ (2004). "Mutual interactions between subunits of the human RNase MRP ribonucleoprotein complex". Nucleic Acids Res. 32 (7): 2138–2146. doi:10.1093/nar/gkh539. PMC 407822. PMID 15096576.
Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–716. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–1718. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.

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