RRN3

RRN3

Identifiers

RRN3, A-270G1.2, TIFIA, RRN3 homolog, RNA polymerase I transcription factor

External IDs

OMIM: 605121; MGI: 1925255; GeneCards: RRN3

Gene location (Human)

Chr.	Chromosome 16 (human)

Band	16p13.11	Start	15,060,033 bp
Band	16p13.11	End	15,094,311 bp

Gene location (Mouse)

Chr.	Chromosome 16 (mouse)

Band	16\|16 A1	Start	13,598,572 bp
Band	16\|16 A1	End	13,632,703 bp

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

Achilles tendon

ganglionic eminence

gastrocnemius muscle

ventricular zone

endometrium

islet of Langerhans

rectum

subcutaneous adipose tissue

ovary

muscle of thigh

Top expressed in

cumulus cell

neural tube

cardiac muscle tissue of left ventricle

epiblast

spermatocyte

morula

morula

ventricular zone

muscle of thigh

ganglionic eminence

More reference expression data


More reference expression data

Gene ontology
Molecular function	RNA polymerase binding RNA polymerase I core promoter sequence-specific DNA binding RNA polymerase I core binding RNA polymerase I general transcription initiation factor activity
Cellular component	nucleolus nucleoplasm nucleus
Biological process	in utero embryonic development nucleolus organization positive regulation of neuron projection development regulation of transcription, DNA-templated cell population proliferation negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator DNA-templated transcription, initiation regulation of DNA-templated transcription, initiation positive regulation of transcription, DNA-templated cytoplasm organization transcription, DNA-templated homeostasis of number of cells transcription initiation from RNA polymerase I promoter ribosome biogenesis regulation of transcription by RNA polymerase I RNA polymerase I preinitiation complex assembly
Sources:Amigo / QuickGO

Databases

NCBI: entry; OMA: entry

Species

Human

Mouse


54700


106298


ENSG00000085721 ENSG00000278494


ENSMUSG00000022682


Q9NYV6


B2RS91

RefSeq (mRNA)


NM_001301064 NM_018427


NM_001039521

RefSeq (protein)


NP_001287993 NP_060897


NP_001034610

Location (UCSC)

Chr 16: 15.06 – 15.09 Mb

Chr 16: 13.6 – 13.63 Mb

PubMed search

View/Edit Human

View/Edit Mouse

RNA polymerase I-specific transcription initiation factor RRN3 is an enzyme that in humans is encoded by the RRN3 gene.

Interactions

RRN3 has been shown to interact with TAF1B.

References

1 2 3 ENSG00000278494 GRCh38: Ensembl release 89: ENSG00000085721, ENSG00000278494 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000022682 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Moorefield B, Greene EA, Reeder RH (May 2000). "RNA polymerase I transcription factor Rrn3 is functionally conserved between yeast and human". Proc. Natl. Acad. Sci. U.S.A. 97 (9): 4724–9. Bibcode:2000PNAS...97.4724M. doi:10.1073/pnas.080063997. PMC 18300. PMID 10758157.
1 2 Miller G, Panov KI, Friedrich JK, Trinkle-Mulcahy L, Lamond AI, Zomerdijk JC (Mar 2001). "hRRN3 is essential in the SL1-mediated recruitment of RNA Polymerase I to rRNA gene promoters". EMBO J. 20 (6): 1373–82. doi:10.1093/emboj/20.6.1373. PMC 145519. PMID 11250903.
↑ "Entrez Gene: RRN3 RRN3 RNA polymerase I transcription factor homolog (S. cerevisiae)".

Further reading

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Bonaldo MF, Lennon G, Soares MB (1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Bodem J, Dobreva G, Hoffmann-Rohrer U, Iben S, Zentgraf H, Delius H, Vingron M, Grummt I (2000). "TIF-IA, the factor mediating growth-dependent control of ribosomal RNA synthesis, is the mammalian homolog of yeast Rrn3p". EMBO Rep. 1 (2): 171–5. doi:10.1093/embo-reports/kvd032. PMC 1084264. PMID 11265758.
Yuan X, Zhao J, Zentgraf H, Hoffmann-Rohrer U, Grummt I (2002). "Multiple interactions between RNA polymerase I, TIF-IA and TAF(I) subunits regulate preinitiation complex assembly at the ribosomal gene promoter". EMBO Rep. 3 (11): 1082–7. doi:10.1093/embo-reports/kvf212. PMC 1307603. PMID 12393749.
Zhao J, Yuan X, Frödin M, Grummt I (2003). "ERK-dependent phosphorylation of the transcription initiation factor TIF-IA is required for RNA polymerase I transcription and cell growth". Mol. Cell. 11 (2): 405–13. doi:10.1016/S1097-2765(03)00036-4. PMID 12620228.
Mayer C, Zhao J, Yuan X, Grummt I (2004). "mTOR-dependent activation of the transcription factor TIF-IA links rRNA synthesis to nutrient availability". Genes Dev. 18 (4): 423–34. doi:10.1101/gad.285504. PMC 359396. PMID 15004009.
Philimonenko VV, Zhao J, Iben S, Dingová H, Kyselá K, Kahle M, Zentgraf H, Hofmann WA, de Lanerolle P, Hozák P, Grummt I (2004). "Nuclear actin and myosin I are required for RNA polymerase I transcription". Nat. Cell Biol. 6 (12): 1165–72. doi:10.1038/ncb1190. PMID 15558034. S2CID 6633625.

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