RUFY1

RUFY1
Identifiers
Aliases	RUFY1, RABIP4, ZFYVE12, RUN and FYVE domain containing 1
External IDs	OMIM: 610327; MGI: 2429762; GeneCards: RUFY1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2YQM, 2YW8
Gene location (Human)
Chr.	Chromosome 5 (human)
End	179,610,012 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	50,321,952 bp
RNA expression pattern
	Top expressed in
	monocyte; ; Achilles tendon; ; sural nerve; ; corpus callosum; ; ventricular zone; ; blood; ; right uterine tube; ; gastric mucosa; ; granulocyte; ; skin of leg;
	Top expressed in
	primary oocyte; ; neural layer of retina; ; right kidney; ; granulocyte; ; muscle of thigh; ; zygote; ; transitional epithelium of urinary bladder; ; proximal tubule; ; retinal pigment epithelium; ; secondary oocyte;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; metal ion binding; lipid binding; SH3 domain binding; SH2 domain binding;
Cellular component	intracellular membrane-bounded organelle; membrane; cytoplasm; cytosol; nuclear speck; early endosome membrane; endosome; nucleus;
Biological process	protein transport; endocytosis; phosphatidylinositol biosynthetic process; regulation of endocytosis; small GTPase mediated signal transduction;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	80230
	216724
	ENSG00000284260; ENSG00000176783
	ENSMUSG00000020375
	Q96T51
	Q8BIJ7
	NM_001040451; NM_001040452; NM_025158
	NM_172557
	NP_001035541; NP_001035542; NP_079434
	NP_766145
	Wikidata
View/Edit Human	View/Edit Mouse

RUN and FYVE domain-containing protein 1 is a protein that in humans is encoded by the RUFY1 gene. It is named after the RUN and FYVE domains it contains.

Interactions

RUFY1 has been shown to interact with BMX.

References

1 2 3 ENSG00000176783 GRCh38: Ensembl release 89: ENSG00000284260, ENSG00000176783 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000020375 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 Yang J, Kim O, Wu J, Qiu Y (Aug 2002). "Interaction between tyrosine kinase Etk and a RUN domain- and FYVE domain-containing protein RUFY1. A possible role of ETK in regulation of vesicle trafficking". J. Biol. Chem. 277 (33): 30219–26. doi:10.1074/jbc.M111933200. PMID 11877430.
↑ "Entrez Gene: RUFY1 RUN and FYVE domain containing 1".

Cormont M, Mari M, Galmiche A, Hofman P, Le Marchand-Brustel Y (2001). "A FYVE-finger-containing protein, Rabip4, is a Rab4 effector involved in early endosomal traffic". Proc. Natl. Acad. Sci. U.S.A. 98 (4): 1637–42. doi:10.1073/pnas.031586998. PMC 29309. PMID 11172003.
Fouraux MA, Deneka M, Ivan V, van der Heijden A, Raymackers J, van Suylekom D, van Venrooij WJ, van der Sluijs P, Pruijn GJ (2004). "Rabip4' is an effector of rab5 and rab4 and regulates transport through early endosomes". Mol. Biol. Cell. 15 (2): 611–24. doi:10.1091/mbc.E03-05-0343. PMC 329268. PMID 14617813.
Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J, Nakai K, Sugano S (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.

This article on a gene on human chromosome 5 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 ENSG00000176783 GRCh38: Ensembl release 89: ENSG00000284260, ENSG00000176783 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000020375 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11877430-5] 1 2 Yang J, Kim O, Wu J, Qiu Y (Aug 2002). "Interaction between tyrosine kinase Etk and a RUN domain- and FYVE domain-containing protein RUFY1. A possible role of ETK in regulation of vesicle trafficking". J. Biol. Chem. 277 (33): 30219–26. doi:10.1074/jbc.M111933200. PMID 11877430.

[entrez-6] "Entrez Gene: RUFY1 RUN and FYVE domain containing 1".

RUFY1

Interactions

References

Further reading