Rachel Haurwitz

Rachel Haurwitz
Haurwitz in 2019
Born
Rachel Elizabeth Haurwitz

(1985-05-20) May 20, 1985 (age 41)
Education
Known forCo-founding Caribou Biosciences
Scientific career
FieldsBiochemistry
WorkplacesCaribou Biosciences
ThesisThe CRISPR endoribonuclease Csy4 utilizes unusual sequence- and structure-specific mechanisms to recognize and process crRNAs (2012)
Jennifer Doudna

Rachel Elizabeth Haurwitz (born May 20, 1985) is an American biochemist and structural biologist. She is the co-founder, chief executive officer, and president of Caribou Biosciences, a genome editing company.

Early life and education

Haurwitz was born on May 20, 1985.[citation needed] She grew up in Austin, Texas. Her mother is an elementary school teacher and her father, an environmental journalist.

Haurwitz began researching RNA during her undergraduate years. She attended Harvard College where she earned an undergraduate degree. In 2007, she began doctoral studies at University of California, Berkeley. At the age of 21, Haurwitz began working as a graduate student in Jennifer Doudna's laboratory, in 2008 where she completed her doctorate in molecular and cell biology. Haurwitz originally intended on becoming an intellectual property lawyer for biotechnology patents but later chose to continue in science.

Career

In 2011, Haurwitz and Doudna co-founded Caribou Biosciences, a gene editing spinout-startup company. Haurwitz is the company's CEO and president. She holds several patents for CRISPR-based technologies. The firm was initially housed in the basement of the building that housed Doudna's laboratory. The company supports the commercialization of CRISPR technology in healthcare and agriculture. Its researchers explore issues in antimicrobial resistance, food scarcity, and vaccine shortages. The company licensed Berkeley's CRISPR patent and deals with agricultural and pharmaceutical companies and research firms. In 2018, Haurwitz announced that the firm was shifting focus on medicine and developing cancer therapies targeting microbes.

In July 2021, Caribou Biosciences became a public company through an initial public offering on the Nasdaq that raised $304 million in gross proceeds. Under Haurwitz's leadership, the company advanced CB-010, an allogeneic anti-CD19 CAR-T cell therapy, through the ANTLER Phase 1 clinical trial in relapsed or refractory B cell non-Hodgkin lymphoma.

In 2024 and 2025, Caribou carried out two rounds of restructuring. In April 2025, the company reduced its workforce by 32 percent and discontinued clinical trials in lupus and acute myeloid leukemia as well as its preclinical research, in order to concentrate on its two lead oncology programs. In November 2025, the company reported positive Phase 1 data for the therapy, by then named vispa-cel, showing efficacy comparable to approved autologous CAR-T cell therapies.

In October 2026, Haurwitz announced Caribou Biosciences is shutting down operations due to an inability "to secure the capital required to responsibly advance" its allogeneic CAR-T cell therapies.

Personal life

She is a long-distance runner and is training for a marathon. Haurwitz knits as a hobby.

Recognition

In 2021, Haurwitz was selected as a Bloomberg New Economy Catalyst. As part of the program, she attended the annual New Economy Forum held in Singapore, and the Bloomberg New Economy Catalyst Retreat that same year. Haurwitz was named to Fortune's 40 Under 40 list in 2016 and MIT Technology Review's Innovators Under 35 in 2017.

Selected works

Papers

References

  1. ↑ Kincaid, Ellie; Tindera, Michela (May 14, 2019). "Gene Hackers: The Young Biotech Entrepreneurs Looking To Make Billions By Editing Life Itself". Forbes.
  2. 1 2 Fosco, Molly (March 16, 2018). "This Scientist Turned CEO Wants to Gene-Edit a Way to Cure Cancer". OZY. Archived from the original on May 9, 2019. Retrieved September 5, 2018.
  3. ↑ Herman, Elizabeth D. (June 22, 2016). "For biotech CEO Rachel Haurwitz, CRISPR is big business". STAT. Retrieved September 5, 2018.
  4. ↑ "The two faces of Rachel Haurwitz". MPNforum Magazine. April 9, 2015. Retrieved September 5, 2018.
  5. 1 2 Buhr, Sarah (September 4, 2018). "These two CRISPR experts are coming to Disrupt SF 2018". TechCrunch. Retrieved September 5, 2018.
  6. 1 2 3 "40 Under 40". Fortune. September 22, 2016. Archived from the original on September 6, 2018. Retrieved September 5, 2018.
  7. ↑ "Rachel Haurwitz". Forbes. Retrieved September 5, 2018.
  8. ↑ Leeming, Jack (April 5, 2018). "How researchers are ensuring that their work has an impact". Nature. 556 (7699): 139–141. Bibcode:2018Natur.556..139L. doi:10.1038/d41586-018-03925-8. ISSN 0028-0836. PMID 29620739.
  9. 1 2 3 "NOMINEE: Rachel Haurwitz". Newsweek. January 18, 2018. Retrieved September 5, 2018.
  10. 1 2 Regalado, Antonio (2017). "One woman's ascent from lab rat to CEO of a CRISPR company". MIT Technology Review. Retrieved September 5, 2018.
  11. ↑ "IPO Raises $304M for Caribou, Developer of Gene-Edited Cell Therapies". Genetic Engineering & Biotechnology News. July 26, 2021.
  12. ↑ Feuerstein, Adam (July 13, 2023). "Caribou posts encouraging durability results on its off-the-shelf CAR-T therapy". STAT.
  13. ↑ Incorvaia, Darren (April 24, 2025). "Caribou cuts 32% of staff, further purges pipeline to focus on 2 oncology CAR-T prospects". Fierce Biotech.
  14. ↑ Fidler, Ben (April 25, 2025). "Caribou, in reversal, scraps autoimmune cell therapy and cuts staff". BioPharma Dive.
  15. ↑ Feuerstein, Adam (November 3, 2025). "Caribou's off-the-shelf CAR-T therapy shows promise in lymphoma study". STAT.
  16. ↑ Incorvaia, Darren (October 7, 2026). "CAR-T biotech Caribou makes 'heartbreaking' call to shrink headcount, halt pipeline". Fierce Biotech. Retrieved October 7, 2026.{{cite news}}: CS1 maint: url-status (link)
  17. ↑ "The Bloomberg New Economy Catalyst List". Bloomberg.com. Retrieved July 19, 2023.