Relaxin-1

RLN1
Identifiers
Aliases	RLN1, H1, H1RLX, RLXH1, bA12D24.3.1, bA12D24.3.2, relaxin 1
External IDs	OMIM: 179730; MGI: 97931; GeneCards: RLN1
Gene location (Human)
Chr.	Chromosome 9 (human)
End	5,339,876 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	29,312,070 bp
RNA expression pattern
	Top expressed in
	oocyte; ; gonad; ; testicle; ; secondary oocyte; ; prostate; ; islet of Langerhans; ; granulocyte; ; buccal mucosa cell; ; anterior pituitary; ; lymph node;
	Top expressed in
	embryo; ; embryo; ; entorhinal cortex; ; choroid plexus of fourth ventricle; ; dentate gyrus of hippocampal formation granule cell; ; CA3 field; ; perirhinal cortex; ; suprachiasmatic nucleus; ; neural tube; ; superior frontal gyrus;
	More reference expression data
	n/a
Gene ontology
Molecular function	hormone activity;
Cellular component	extracellular region;
Biological process	signal transduction; female pregnancy; regulation of signaling receptor activity;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	6013
	19773
	ENSG00000107018
	ENSMUSG00000039097
	P04808
	P47932
	NM_006911
	NM_011272
	NP_008842
	NP_035402
	Wikidata
View/Edit Human	View/Edit Mouse

Relaxin-1 is a primate-specific peptide hormone that in humans is encoded by the gene RLN1. Relaxin-1 is a relaxin-like peptide which is particularly closely related to the pregnancy relaxin hormone (RLN2), but is expressed in the prostate and not the ovaries, placenta, or decidua.

Evolution

The RLN1 and RLN2 genes split off from a single precursor gene due to a relatively recent duplication event. Because of this, most mammals only have a single gene that is related to both, but is functionally most similar to RLN2, and confusingly often called Rln1.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000107018 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000039097 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 "Prorelaxin H1". uniprot.org. UniProt consortium. Retrieved 2026-10-24.
1 2 Feijóo-Bandín S, Aragón-Herrera A, Rodríguez-Penas D, Portolés M, Roselló-Lletí E, Rivera M, González-Juanatey JR, Lago F (2017-08-18). "Relaxin-2 in cardiometabolic diseases: mechanisms of action and future perspectives". Frontiers in physiology. 8: 599. doi:10.3389/fphys.2017.00599.
↑ Arroyo JI, Hoffmann FG, Opazo JC (March 2014). "Evolution of the relaxin/insulin-like gene family in anthropoid primates". Genome Biology and Evolution. 6 (3): 491–9. doi:10.1093/gbe/evu023. PMC 3971578. PMID 24493383.

This article on a gene on human chromosome 9 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000107018 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000039097 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[uniprot-5] 1 2 "Prorelaxin H1". uniprot.org. UniProt consortium. Retrieved 2026-10-24.

[Feijoo2017-6] 1 2 Feijóo-Bandín S, Aragón-Herrera A, Rodríguez-Penas D, Portolés M, Roselló-Lletí E, Rivera M, González-Juanatey JR, Lago F (2017-08-18). "Relaxin-2 in cardiometabolic diseases: mechanisms of action and future perspectives". Frontiers in physiology. 8: 599. doi:10.3389/fphys.2017.00599.

[Arroyo_2014-7] Arroyo JI, Hoffmann FG, Opazo JC (March 2014). "Evolution of the relaxin/insulin-like gene family in anthropoid primates". Genome Biology and Evolution. 6 (3): 491–9. doi:10.1093/gbe/evu023. PMC 3971578. PMID 24493383.