RpoE

ECF RNA polymerase sigma-E factor
Identifiers
OrganismEscherichia coli (strain K12)
SymbolrpoE
Alt. symbolssigE
Entrez67175910
OrthologsNCBI: entry; OMA: entry
PDB1OR7, 2H27, 5OR5, 6JBQ
RefSeq (mRNA)NC_000913
RefSeq (Prot)NP_417068
UniProtP0AGB6
Other data
Chromosomegenomic: 2.71 - 2.71 Mb
Search for
StructuresSwiss-model
DomainsInterPro

The gene rpoE (RNA polymerase, extracytoplasmic E) encodes the sigma factor sigma-24 (σ24, sigma E, or RpoE), a protein in Escherichia coli and other species of bacteria. Depending on the bacterial species, this gene may be referred to as sigE.

RpoE appears to be necessary for the exocytoplasmic stress response. E. coli mutants without rpoE cannot grow at high temperatures (that is, above 42 degrees C) and show growth defects at lower temperatures, though this may be due to compensatory mutations.

The stress response regulation activities of RpoE are modulated by the Hfq protein in E. coli.

References

  1. ↑ Rouvière PE, De Las Peñas A, Mecsas J, Lu CZ, Rudd KE, Gross CA (March 1995). "rpoE, the gene encoding the second heat-shock sigma factor, sigma E, in Escherichia coli". The EMBO Journal. 14 (5): 1032–1042. doi:10.1002/j.1460-2075.1995.tb07084.x. PMC 398175. PMID 7889934.
  2. ↑ Jensen-Cain DM, Quinn FD (May 2001). "Differential expression of sigE by Mycobacterium tuberculosis during intracellular growth". Microbial Pathogenesis. 30 (5): 271–278. doi:10.1006/mpat.2001.0431. PMID 11373121.
  3. ↑ Hiratsu K, Amemura M, Nashimoto H, Shinagawa H, Makino K (May 1995). "The rpoE gene of Escherichia coli, which encodes sigma E, is essential for bacterial growth at high temperature". Journal of Bacteriology. 177 (10): 2918–2922. doi:10.1128/jb.177.10.2918-2922.1995. PMC 176969. PMID 7751307.
  4. 1 2 De Las Peñas A, Connolly L, Gross CA (November 1997). "SigmaE is an essential sigma factor in Escherichia coli". Journal of Bacteriology. 179 (21): 6862–6864. doi:10.1128/jb.179.21.6862-6864.1997. PMC 179621. PMID 9352942.