SAFB2

SAFB2

Identifiers

SAFB2, scaffold attachment factor B2

External IDs

OMIM: 608066; MGI: 2146808; GeneCards: SAFB2

Gene location (Human)

Chr.	Chromosome 19 (human)

Band	19p13.3	Start	5,586,999 bp
Band	19p13.3	End	5,624,046 bp

Gene location (Mouse)

Chr.	Chromosome 17 (mouse)

Band	17\|17 D	Start	56,560,965 bp
Band	17\|17 D	End	56,584,585 bp

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

right hemisphere of cerebellum

anterior pituitary

right uterine tube

left ovary

right ovary

sural nerve

canal of the cervix

body of uterus

right lobe of thyroid gland

left lobe of thyroid gland

Top expressed in

neural layer of retina

granulocyte

ventricular zone

yolk sac

superior frontal gyrus

tail of embryo

thymus

lip

primary visual cortex

muscle of thigh

More reference expression data


More reference expression data

Gene ontology
Molecular function	DNA binding nucleic acid binding identical protein binding protein binding double-stranded DNA binding RNA binding sequence-specific DNA binding
Cellular component	extracellular exosome nucleoplasm cytoplasm intracellular membrane-bounded organelle nucleus nuclear body
Biological process	regulation of transcription, DNA-templated transcription, DNA-templated Sertoli cell differentiation regulation of transcription by RNA polymerase II regulation of androgen receptor signaling pathway regulation of mRNA processing
Sources:Amigo / QuickGO

Databases

NCBI: entry; OMA: entry

Species

Human

Mouse


9667


224902


ENSG00000130254


ENSMUSG00000042625


Q14151


Q80YR5

RefSeq (mRNA)


NM_014649


NM_001029979 NM_001355463

RefSeq (protein)


NP_055464


NP_001025150 NP_001342392

Location (UCSC)

Chr 19: 5.59 – 5.62 Mb

Chr 17: 56.56 – 56.58 Mb

PubMed search

View/Edit Human

View/Edit Mouse

Scaffold attachment factor B2 is a protein that in humans is encoded by the SAFB2 gene.

Interactions

SAFB2 has been shown to interact with Estrogen receptor alpha and SAFB.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000130254 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000042625 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 3 Townson SM, Dobrzycka KM, Lee AV, Air M, Deng W, Kang K, Jiang S, Kioka N, Michaelis K, Oesterreich S (May 2003). "SAFB2, a new scaffold attachment factor homolog and estrogen receptor corepressor". J. Biol. Chem. 278 (22): 20059–68. doi:10.1074/jbc.M212988200. PMID 12660241.
↑ "Entrez Gene: SAFB2 scaffold attachment factor B2".

Further reading

Oesterreich S (2003). "Scaffold attachment factors SAFB1 and SAFB2: Innocent bystanders or critical players in breast tumorigenesis?". J. Cell. Biochem. 90 (4): 653–61. doi:10.1002/jcb.10685. PMID 14587024. S2CID 39178501.
Nagase T, Seki N, Tanaka A, Ishikawa K, Nomura N (1995). "Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 2 (4): 167–74, 199–210. doi:10.1093/dnares/2.4.167. PMID 8590280.
Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Ballif BA, Villén J, Beausoleil SA, Schwartz D, Gygi SP (2004). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell. Proteomics. 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.

This article on a gene on human chromosome 19 is a stub. You can help Wikipedia by adding missing information.