SCN4B

SCN4B
Identifiers
Aliases	SCN4B, ATFB17, LQT10, Navbeta4, sodium voltage-gated channel beta subunit 4
External IDs	OMIM: 608256; MGI: 2687406; GeneCards: SCN4B
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4MZ2, 4MZ3
Gene location (Human)
Chr.	Chromosome 11 (human)
End	118,152,888 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	45,065,450 bp
RNA expression pattern
	Top expressed in
	external globus pallidus; ; spinal ganglia; ; putamen; ; right hemisphere of cerebellum; ; pons; ; caudate nucleus; ; lateral nuclear group of thalamus; ; primary visual cortex; ; Brodmann area 23; ; trigeminal ganglion;
	Top expressed in
	triceps brachii muscle; ; ankle; ; vastus lateralis muscle; ; sternocleidomastoid muscle; ; temporal muscle; ; knee joint; ; digastric muscle; ; extraocular muscle; ; medial head of gastrocnemius muscle; ; muscle of thigh;
	More reference expression data
	n/a
Gene ontology
Molecular function	sodium channel regulator activity; transmembrane transporter binding; sodium channel activity; voltage-gated ion channel activity; voltage-gated sodium channel activity involved in cardiac muscle cell action potential; voltage-gated sodium channel activity;
Cellular component	voltage-gated sodium channel complex; integral component of membrane; membrane; intercalated disc; intrinsic component of plasma membrane; plasma membrane;
Biological process	cardiac muscle contraction; sodium ion transmembrane transport; sodium ion transport; regulation of ion transmembrane transport; cardiac muscle cell action potential involved in contraction; ion transport; regulation of sodium ion transmembrane transporter activity; positive regulation of sodium ion transport; AV node cell action potential; regulation of heart rate by cardiac conduction; membrane depolarization during cardiac muscle cell action potential; regulation of ventricular cardiac muscle cell membrane repolarization;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	6330
	399548
	ENSG00000177098
	ENSMUSG00000046480
	Q8IWT1
	Q7M729
	NM_001142348; NM_001142349; NM_174934
	NM_001013390
	NP_001135820; NP_001135821; NP_777594
	NP_001013408
	Wikidata
View/Edit Human	View/Edit Mouse

Sodium channel β-subunit 4, also known as SCN4B or Naβ4, is an auxiliary sodium channel subunit that can alter the kinetics of sodium channels. The protein is encoded by the SCN4B gene. Mutations in the SCN4B are associated with long QT syndrome.

SCN4B might additionally function as a cell adhesion molecule.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000177098 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000046480 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Lewis AH, Raman IM (2014-11-15). "Resurgent current of voltage-gated Na+ channels". The Journal of Physiology. 592 (22): 4825–4838. doi:10.1113/jphysiol.2014.277582. ISSN 1469-7793. PMC 4259529. PMID 25172941.
↑ "Entrez Gene: sodium channel".
↑ Medeiros-Domingo A, Kaku T, Tester DJ, Iturralde-Torres P, Itty A, Ye B, et al. (July 2007). "SCN4B-encoded sodium channel beta4 subunit in congenital long-QT syndrome". Circulation. 116 (2): 134–142. doi:10.1161/CIRCULATIONAHA.106.659086. PMC 3332546. PMID 17592081.
↑ Shimizu H (2016). "Structure-based site-directed photo-crosslinking analyses of multimeric cell-adhesive interactions of voltage-gated sodium channel β subunits". Scientific Reports. 6 26618. Bibcode:2016NatSR...626618S. doi:10.1038/srep26618. PMC 4877568. PMID 27216889.
↑ Shimizu H (2017). "Parallel homodimer structures of the extracellular domains of the voltage-gated sodium channel β4 subunit explain its role in cell-cell adhesion". J Biol Chem. 27 (32): 13428–13440. doi:10.1074/jbc.M117.786509. PMC 5555201. PMID 28655765.

External links

Overview of all the structural information available in the PDB for UniProt: Q8IWT1 (Human Sodium channel subunit beta-4 (SCN4B)) at the PDBe-KB.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000177098 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000046480 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Lewis AH, Raman IM (2014-11-15). "Resurgent current of voltage-gated Na+ channels". The Journal of Physiology. 592 (22): 4825–4838. doi:10.1113/jphysiol.2014.277582. ISSN 1469-7793. PMC 4259529. PMID 25172941.

[entrez-6] "Entrez Gene: sodium channel".

[pmid17592081-7] Medeiros-Domingo A, Kaku T, Tester DJ, Iturralde-Torres P, Itty A, Ye B, et al. (July 2007). "SCN4B-encoded sodium channel beta4 subunit in congenital long-QT syndrome". Circulation. 116 (2): 134–142. doi:10.1161/CIRCULATIONAHA.106.659086. PMC 3332546. PMID 17592081.

[pmid27216889-8] Shimizu H (2016). "Structure-based site-directed photo-crosslinking analyses of multimeric cell-adhesive interactions of voltage-gated sodium channel β subunits". Scientific Reports. 6 26618. Bibcode:2016NatSR...626618S. doi:10.1038/srep26618. PMC 4877568. PMID 27216889.

[pmid28655765-9] Shimizu H (2017). "Parallel homodimer structures of the extracellular domains of the voltage-gated sodium channel β4 subunit explain its role in cell-cell adhesion". J Biol Chem. 27 (32): 13428–13440. doi:10.1074/jbc.M117.786509. PMC 5555201. PMID 28655765.

SCN4B

See also

References

Further reading

External links