Syntenin-2

SDCBP2

Identifiers

SDCBP2, SITAC, SITAC18, ST-2, syndecan binding protein 2, ST2

External IDs

OMIM: 617358; MGI: 2385156; GeneCards: SDCBP2

Gene location (Human)

Chr.	Chromosome 20 (human)

Band	20p13	Start	1,309,909 bp
Band	20p13	End	1,329,139 bp

Gene location (Mouse)

Chr.	Chromosome 2 (mouse)

Band	2\|2 G3	Start	151,414,542 bp
Band	2\|2 G3	End	151,431,925 bp

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

mucosa of ileum

mucosa of transverse colon

jejunal mucosa

mucosa of sigmoid colon

pancreatic ductal cell

rectum

nasal epithelium

gallbladder

skin of leg

duodenum

Top expressed in

mucous cell of stomach

pyloric antrum

epithelium of stomach

duodenum

intestinal villus

esophagus

jejunum

left colon

lip

ileum

More reference expression data

n/a

Gene ontology
Molecular function	protein C-terminus binding protein binding protein homodimerization activity protein heterodimerization activity identical protein binding phosphatidylinositol-4,5-bisphosphate binding lipid binding
Cellular component	extracellular exosome nucleus nucleoplasm nucleolus cytoplasm plasma membrane membrane nuclear speck
Biological process	intracellular signal transduction intracellular transport nervous system development cell population proliferation
Sources:Amigo / QuickGO

Databases

NCBI: entry; OMA: entry

Species

Human

Mouse


27111


228765


ENSG00000125775


ENSMUSG00000027456


Q9H190


Q99JZ0

RefSeq (mRNA)


NM_080489 NM_001199784 NM_015685


NM_145535

RefSeq (protein)


NP_001186713 NP_056500 NP_536737


NP_663510

Location (UCSC)

Chr 20: 1.31 – 1.33 Mb

Chr 2: 151.41 – 151.43 Mb

PubMed search

View/Edit Human

View/Edit Mouse

Syntenin-2 is a protein that in humans is encoded by the SDCBP2 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000125775 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000027456 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Koroll M, Rathjen FG, Volkmer H (Apr 2001). "The neural cell recognition molecule neurofascin interacts with syntenin-1 but not with syntenin-2, both of which reveal self-associating activity". J Biol Chem. 276 (14): 10646–54. doi:10.1074/jbc.M010647200. PMID 11152476.
↑ "Entrez Gene: SDCBP2 syndecan binding protein (syntenin) 2".

Further reading

Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
Borrell-Pagès M, Fernández-Larrea J, Borroto A, et al. (2001). "The carboxy-terminal cysteine of the tetraspanin L6 antigen is required for its interaction with SITAC, a novel PDZ protein". Mol. Biol. Cell. 11 (12): 4217–25. doi:10.1091/mbc.11.12.4217. PMC 15068. PMID 11102519.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi:10.1038/414865a. PMID 11780052.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.

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