SDF4

SDF4

Identifiers

SDF4, Cab45, SDF-4, stromal cell derived factor 4

External IDs

OMIM: 614282; MGI: 108079; GeneCards: SDF4

Gene location (Human)

Chr.	Chromosome 1 (human)

Band	1p36.33	Start	1,216,909 bp
Band	1p36.33	End	1,232,067 bp

Gene location (Mouse)

Chr.	Chromosome 4 (mouse)

Band	4\|4 E2	Start	156,077,329 bp
Band	4\|4 E2	End	156,098,067 bp

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

stromal cell of endometrium

right hemisphere of cerebellum

cartilage tissue

mucosa of transverse colon

thoracic aorta

ascending aorta

Descending thoracic aorta

right auricle of heart

cardia

right coronary artery

Top expressed in

stroma of bone marrow

molar

supraoptic nucleus

dentate gyrus of hippocampal formation granule cell

spermatocyte

mesenteric lymph nodes

calvaria

right lung lobe

duodenum

superior frontal gyrus

More reference expression data


More reference expression data

Gene ontology
Molecular function	protein binding metal ion binding identical protein binding calcium ion binding
Cellular component	cell projection extracellular exosome bleb late endosome Golgi lumen cytoplasm membrane plasma membrane Golgi apparatus endoplasmic reticulum
Biological process	UV protection zymogen granule exocytosis response to ethanol cerebellum development calcium-ion regulated exocytosis exocytosis fat cell differentiation
Sources:Amigo / QuickGO

Databases

NCBI: entry; OMA: entry

Species

Human

Mouse


51150


20318


ENSG00000078808


ENSMUSG00000029076


Q9BRK5


Q61112

RefSeq (mRNA)


NM_016176 NM_016547


NM_011341 NM_001302467 NM_001302468 NM_001302469

RefSeq (protein)


NP_057260 NP_057631


NP_001289396 NP_001289397 NP_001289398 NP_035471

Location (UCSC)

Chr 1: 1.22 – 1.23 Mb

Chr 4: 156.08 – 156.1 Mb

PubMed search

View/Edit Human

View/Edit Mouse

45 kDa calcium-binding protein is a protein that in humans is encoded by the SDF4 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000078808 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029076 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Koivu T, Laitinen S, Riento K, Olkkonen VM (Sep 1997). "Sequence of a human cDNA encoding Cab45, a Ca2+-binding protein with six EF-hand motifs". DNA Seq. 7 (3–4): 217–20. doi:10.3109/10425179709034038. PMID 9254016.
↑ Scherer PE, Lederkremer GZ, Williams S, Fogliano M, Baldini G, Lodish HF (May 1996). "Cab45, a novel (Ca2+)-binding protein localized to the Golgi lumen". J Cell Biol. 133 (2): 257–68. doi:10.1083/jcb.133.2.257. PMC 2120788. PMID 8609160.
↑ "Entrez Gene: SDF4 stromal cell derived factor 4".

Further reading

Honoré B, Vorum H (2000). "The CREC family, a novel family of multiple EF-hand, low-affinity Ca(2+)-binding proteins localised to the secretory pathway of mammalian cells". FEBS Lett. 466 (1): 11–8. doi:10.1016/S0014-5793(99)01780-9. PMID 10648803.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
Lam PP, Hyvärinen K, Kauppi M, et al. (2007). "A cytosolic splice variant of Cab45 interacts with Munc18b and impacts on amylase secretion by pancreatic acini". Mol. Biol. Cell. 18 (7): 2473–80. doi:10.1091/mbc.E06-10-0950. PMC 1924827. PMID 17442889.

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