SEC14L2

SEC14L2
Identifiers
Aliases	SEC14L2, C22orf6, SPF, TAP, TAP1, SEC14 like lipid binding 2
External IDs	OMIM: 607558; MGI: 1915065; GeneCards: SEC14L2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1O6U, 1OLM, 4OMJ, 4OMK,%%s1O6U, 1OLM
Gene location (Human)
Chr.	Chromosome 22 (human)
End	30,425,303 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	4,073,415 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; right frontal lobe; ; prefrontal cortex; ; nucleus accumbens; ; amygdala; ; C1 segment; ; cingulate gyrus; ; caudate nucleus; ; putamen; ; anterior cingulate cortex;
	Top expressed in
	superior surface of tongue; ; left lobe of liver; ; gallbladder; ; olfactory epithelium; ; yolk sac; ; neural layer of retina; ; dentate gyrus of hippocampal formation granule cell; ; jejunum; ; retinal pigment epithelium; ; cingulate gyrus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	vitamin E binding; phospholipid binding; lipid binding; transporter activity;
Cellular component	cytoplasm; integral component of membrane; extracellular exosome; intracellular anatomical structure; nucleus; cytosol;
Biological process	regulation of cholesterol biosynthetic process; positive regulation of transcription, DNA-templated; regulation of transcription, DNA-templated; transcription, DNA-templated; transport;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	23541
	67815
	ENSG00000100003
	ENSMUSG00000003585
	O76054
	Q99J08
	NM_033382; NM_001204204; NM_001291932; NM_012429
	NM_144520
	NP_001191133; NP_001278861; NP_036561; NP_203740; NP_036561.1
	NP_653103
	Wikidata
View/Edit Human	View/Edit Mouse

SEC14L2 is a gene that, in humans, encodes the protein SEC14-like protein 2.

Function

This gene encodes a cytosolic protein which belongs to a family of lipid-binding proteins including Sec14p, alpha-tocopherol transfer protein, and cellular retinol-binding protein. The encoded protein stimulates squalene monooxygenase which is a downstream enzyme in biosynthesis and metabolism of cholesterol.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000100003 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000003585 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, et al. (December 1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–495. Bibcode:1999Natur.402..489D. doi:10.1038/990031. PMID 10591208.
1 2 "Entrez Gene: SEC14L2 SEC14-like 2 (S. cerevisiae)".

Caras IW, Friedlander EJ, Bloch K (1980). "Interactions of supernatant protein factor with components of the microsomal squalene epoxidase system. Binding of supernatant protein factor to anionic phospholipids". The Journal of Biological Chemistry. 255 (8): 3575–3580. doi:10.1016/S0021-9258(19)85740-X. PMID 7364757.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–174. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Solheim JC, Harris MR, Kindle CS, Hansen TH (1997). "Prominence of beta 2-microglobulin, class I heavy chain conformation, and tapasin in the interactions of class I heavy chain with calreticulin and the transporter associated with antigen processing". Journal of Immunology. 158 (5): 2236–2241. doi:10.4049/jimmunol.158.5.2236. PMID 9036970. S2CID 30900833.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–156. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
"Toward a complete human genome sequence". Genome Research. 8 (11): 1097–1108. November 1998. doi:10.1101/gr.8.11.1097. PMID 9847074.
Hirosawa M, Nagase T, Ishikawa K, Kikuno R, Nomura N, Ohara O (2000). "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain". DNA Research. 6 (5): 329–336. doi:10.1093/dnares/6.5.329. PMID 10574461.
Zimmer S, Stocker A, Sarbolouki MN, Spycher SE, Sassoon J, Azzi A (2000). "A novel human tocopherol-associated protein: cloning, in vitro expression, and characterization". The Journal of Biological Chemistry. 275 (33): 25672–25680. doi:10.1074/jbc.M000851200. PMID 10829015.
Shibata N, Arita M, Misaki Y, Dohmae N, Takio K, Ono T, et al. (2001). "Supernatant protein factor, which stimulates the conversion of squalene to lanosterol, is a cytosolic squalene transfer protein and enhances cholesterol biosynthesis". Proceedings of the National Academy of Sciences of the United States of America. 98 (5): 2244–2249. Bibcode:2001PNAS...98.2244S. doi:10.1073/pnas.041620398. PMC 30123. PMID 11226224.
Hirosawa M, Nagase T, Murahashi Y, Kikuno R, Ohara O (2001). "Identification of novel transcribed sequences on human chromosome 22 by expressed sequence tag mapping". DNA Research. 8 (1): 1–9. doi:10.1093/dnares/8.1.1. PMID 11258795.
Yamauchi J, Iwamoto T, Kida S, Masushige S, Yamada K, Esashi T (2001). "Tocopherol-associated protein is a ligand-dependent transcriptional activator". Biochemical and Biophysical Research Communications. 285 (2): 295–299. doi:10.1006/bbrc.2001.5162. PMID 11444841.
Stocker A, Tomizaki T, Schulze-Briese C, Baumann U (2003). "Crystal structure of the human supernatant protein factor". Structure. 10 (11): 1533–1540. doi:10.1016/S0969-2126(02)00884-5. PMID 12429094.
Singh DK, Mokashi V, Elmore CL, Porter TD (2003). "Phosphorylation of supernatant protein factor enhances its ability to stimulate microsomal squalene monooxygenase". The Journal of Biological Chemistry. 278 (8): 5646–5651. doi:10.1074/jbc.M211750200. PMID 12454003.
Kempná P, Zingg JM, Ricciarelli R, Hierl M, Saxena S, Azzi A (2004). "Cloning of novel human SEC14p-like proteins: ligand binding and functional properties". Free Radical Biology & Medicine. 34 (11): 1458–1472. doi:10.1016/S0891-5849(03)00173-4. PMID 12757856.
Stocker A, Baumann U (2003). "Supernatant protein factor in complex with RRR-alpha-tocopherylquinone: a link between oxidized Vitamin E and cholesterol biosynthesis". Journal of Molecular Biology. 332 (4): 759–765. doi:10.1016/S0022-2836(03)00924-0. PMID 12972248.
Mokashi V, Singh DK, Porter TD (2004). "Rat supernatant protein factor-like protein stimulates squalene monooxygenase and is activated by protein kinase A". Biochemical and Biophysical Research Communications. 316 (3): 688–692. doi:10.1016/j.bbrc.2004.02.103. PMID 15033454.
Collins JE, Wright CL, Edwards CA, Davis MP, Grinham JA, Cole CG, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biology. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
Cheng J, Kapranov P, Drenkow J, Dike S, Brubaker S, Patel S, et al. (2005). "Transcriptional maps of 10 human chromosomes at 5-nucleotide resolution". Science. 308 (5725): 1149–1154. Bibcode:2005Sci...308.1149C. doi:10.1126/science.1108625. PMID 15790807. S2CID 13047538.

This article on a gene on human chromosome 22 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000100003 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000003585 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10591208-5] Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, et al. (December 1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–495. Bibcode:1999Natur.402..489D. doi:10.1038/990031. PMID 10591208.

[entrez-6] 1 2 "Entrez Gene: SEC14L2 SEC14-like 2 (S. cerevisiae)".

SEC14L2

Function

References

Further reading