SEC24D Protein-coding gene in the species Homo sapiens
Protein transport protein Sec24D is a protein that in humans is encoded by the SEC24D gene .
The protein encoded by this gene is a member of the SEC24 subfamily of the SEC23/SEC24 family, which is involved in vesicle trafficking . The encoded protein has similarity to yeast Sec24p component of COPII . COPII is the coat protein complex responsible for vesicle budding from the ER . The role of this gene product is implicated in the shaping of the vesicle, and also in cargo selection and concentration.
References
1 2 3 GRCh38: Ensembl release 89: ENSG00000150961 – Ensembl , May 20171 2 3 GRCm38: Ensembl release 89: ENSMUSG00000039234 – Ensembl , May 2017↑ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .↑ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .↑ Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Apr 1999). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro" . DNA Res . 5 (5): 277– 86. doi :10.1093/dnares/5.5.277 PMID 9872452 . ↑ Pagano A, Letourneur F, Garcia-Estefania D, Carpentier JL, Orci L, Paccaud JP (Apr 1999). "Sec24 proteins and sorting at the endoplasmic reticulum" . J Biol Chem . 274 (12): 7833– 40. doi :10.1074/jbc.274.12.7833 PMID 10075675 . 1 2 "Entrez Gene: SEC24D SEC24 related gene family, member D (S. cerevisiae)" .
Further reading
Tang BL, Kausalya J, Low DY, et al. (1999). "A family of mammalian proteins homologous to yeast Sec24p". Biochem. Biophys. Res. Commun . 258 (3): 679– 84. doi :10.1006/bbrc.1999.0574 . PMID 10329445 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899– 903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40– 5. doi :10.1038/ng1285 PMID 14702039 . Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway" . Genome Res . 14 (7): 1324– 32. doi :10.1101/gr.2334104 . PMC 442148 PMID 15231748 . Watson P, Forster R, Palmer KJ, et al. (2005). "Coupling of ER exit to microtubules through direct interaction of COPII with dynactin" . Nat. Cell Biol . 7 (1): 48– 55. doi :10.1038/ncb1206 . PMC 1592520 PMID 15580264 . Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature . 437 (7062): 1173– 8. Bibcode :2005Natur.437.1173R . doi :10.1038/nature04209 . PMID 16189514 . S2CID 4427026 . Farhan H, Reiterer V, Korkhov VM, et al. (2007). "Concentrative export from the endoplasmic reticulum of the gamma-aminobutyric acid transporter 1 requires binding to SEC24D" . J. Biol. Chem . 282 (10): 7679– 89. doi :10.1074/jbc.M609720200 PMID 17210573 .
