Selenoprotein T

SELENOT
Identifiers
Aliases	SELENOT, SELT, selenoprotein T
External IDs	OMIM: 607912; MGI: 1916477; GeneCards: SELENOT
Enzyme activity
Gene location (Human)
Chr.	Chromosome 3 (human)
End	150,630,436 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	58,500,554 bp
RNA expression pattern
	Top expressed in
	islet of Langerhans; ; right adrenal gland; ; right adrenal cortex; ; internal globus pallidus; ; left adrenal gland; ; monocyte; ; beta cell; ; stromal cell of endometrium; ; left adrenal cortex; ; prefrontal cortex;
	Top expressed in
	olfactory epithelium; ; iris; ; median eminence; ; sciatic nerve; ; primitive streak; ; Epithelium of choroid plexus; ; barrel cortex; ; Region I of hippocampus proper; ; vestibular membrane of cochlear duct; ; endothelial cell of lymphatic vessel;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	selenium binding; thioredoxin-disulfide reductase activity; oxidoreductase activity;
Cellular component	endoplasmic reticulum; endoplasmic reticulum membrane; membrane; integral component of membrane;
Biological process	selenocysteine incorporation; positive regulation of cytosolic calcium ion concentration; positive regulation of growth hormone secretion; cellular oxidant detoxification; response to glucose; pancreas development; insulin secretion involved in cellular response to glucose stimulus; glucose homeostasis; cell redox homeostasis;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	51714
	69227
	ENSG00000198843
	ENSMUSG00000075700
	P62341
	P62342
	NM_016275
	NM_001040396; NM_026997
	NP_057359
	NP_001035486
	Wikidata
View/Edit Human	View/Edit Mouse

Selenoprotein T, is a protein that in humans is encoded by the SELENOT gene (previously SELT).

Gene

The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal.

Protein structure

Selenoprotein T contains a selenocysteine (Sec) residue at its active site.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000198843 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000075700 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Kryukov GV, Kryukov VM, Gladyshev VN (November 1999). "New mammalian selenocysteine-containing proteins identified with an algorithm that searches for selenocysteine insertion sequence elements". J. Biol. Chem. 274 (48): 33888–97. doi:10.1074/jbc.274.48.33888. PMID 10567350.
↑ Kryukov GV, Castellano S, Novoselov SV, Lobanov AV, Zehtab O, Guigó R, Gladyshev VN (May 2003). "Characterization of mammalian selenoproteomes". Science. 300 (5624): 1439–43. Bibcode:2003Sci...300.1439K. doi:10.1126/science.1083516. PMID 12775843. S2CID 10363908.
1 2 "Entrez Gene: SELT selenoprotein T".

Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.

This article on a gene on human chromosome 3 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000198843 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000075700 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10567350-5] Kryukov GV, Kryukov VM, Gladyshev VN (November 1999). "New mammalian selenocysteine-containing proteins identified with an algorithm that searches for selenocysteine insertion sequence elements". J. Biol. Chem. 274 (48): 33888–97. doi:10.1074/jbc.274.48.33888. PMID 10567350.

[pmid12775843-6] Kryukov GV, Castellano S, Novoselov SV, Lobanov AV, Zehtab O, Guigó R, Gladyshev VN (May 2003). "Characterization of mammalian selenoproteomes". Science. 300 (5624): 1439–43. Bibcode:2003Sci...300.1439K. doi:10.1126/science.1083516. PMID 12775843. S2CID 10363908.

[entrez-7] 1 2 "Entrez Gene: SELT selenoprotein T".

Selenoprotein T

Gene

Protein structure

See also

References

Further reading