SEMA3C

SEMA3C

Identifiers

SEMA3C, SEMAE, SemE, semaphorin 3C

External IDs

OMIM: 602645; MGI: 107557; GeneCards: SEMA3C

Gene location (Human)

Chr.	Chromosome 7 (human)

Band	7q21.11	Start	80,742,538 bp
Band	7q21.11	End	80,922,359 bp

Gene location (Mouse)

Chr.	Chromosome 5 (mouse)

Band	5\|5 A3	Start	17,779,279 bp
Band	5\|5 A3	End	17,935,266 bp

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

lactiferous duct

synovial joint

Achilles tendon

cartilage tissue

germinal epithelium

skin of hip

vena cava

synovial membrane

tail of epididymis

biceps brachii

Top expressed in

retinal pigment epithelium

right lung lobe

submandibular gland

ankle

medullary collecting duct

left colon

calvaria

skin of external ear

vas deferens

seminal vesicula

More reference expression data


More reference expression data

Gene ontology
Molecular function	semaphorin receptor binding neuropilin binding chemorepellent activity
Cellular component	extracellular region extracellular exosome extracellular space integral component of plasma membrane
Biological process	somitogenesis cell differentiation limb bud formation outflow tract morphogenesis post-embryonic development nervous system development axon guidance multicellular organism development development of the heart blood vessel remodeling pulmonary myocardium development immune response neural tube development dichotomous subdivision of terminal units involved in salivary gland branching cardiac right ventricle morphogenesis neural crest cell migration negative chemotaxis outflow tract septum morphogenesis semaphorin-plexin signaling pathway cardiac endothelial to mesenchymal transition positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis positive regulation of cell migration negative regulation of axon extension involved in axon guidance
Sources:Amigo / QuickGO

Databases

NCBI: entry; OMA: entry

Species

Human

Mouse


10512


20348


ENSG00000075223


ENSMUSG00000028780


Q99985


Q62181

RefSeq (mRNA)


NM_006379 NM_001350120 NM_001350121


NM_013657

RefSeq (protein)


NP_006370 NP_001337049 NP_001337050


NP_038685

Location (UCSC)

Chr 7: 80.74 – 80.92 Mb

Chr 5: 17.78 – 17.94 Mb

PubMed search

View/Edit Human

View/Edit Mouse

Semaphorin-3C is a protein that in humans is encoded by the SEMA3C gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000075223 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028780 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Püschel AW, Adams RH, Betz H (May 1995). "Murine semaphorin D/collapsin is a member of a diverse gene family and creates domains inhibitory for axonal extension". Neuron. 14 (5): 941–8. doi:10.1016/0896-6273(95)90332-1. PMID 7748561.
↑ Mangasser-Stephan K, Dooley S, Welter C, Mutschler W, Hanselmann RG (May 1997). "Identification of human semaphorin E gene expression in rheumatoid synovial cells by mRNA differential display". Biochemical and Biophysical Research Communications. 234 (1): 153–6. doi:10.1006/bbrc.1997.6607. PMID 9168980.
↑ "Entrez Gene: SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C".

Further reading

Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA, Bieber FR, Morton CC (September 1994). "Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening". Genomics. 23 (1): 42–50. doi:10.1006/geno.1994.1457. hdl:10669/15162. PMID 7829101.
Bonaldo MF, Lennon G, Soares MB (September 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Chen H, Chédotal A, He Z, Goodman CS, Tessier-Lavigne M (September 1997). "Neuropilin-2, a novel member of the neuropilin family, is a high affinity receptor for the semaphorins Sema E and Sema IV but not Sema III". Neuron. 19 (3): 547–59. doi:10.1016/S0896-6273(00)80371-2. PMID 9331348. S2CID 17985062.
Yamada T, Endo R, Gotoh M, Hirohashi S (December 1997). "Identification of semaphorin E as a non-MDR drug resistance gene of human cancers". Proceedings of the National Academy of Sciences of the United States of America. 94 (26): 14713–8. Bibcode:1997PNAS...9414713Y. doi:10.1073/pnas.94.26.14713. PMC 25101. PMID 9405678.
Galani E, Sgouros J, Petropoulou C, Janinis J, Aravantinos G, Dionysiou-Asteriou D, Skarlos D, Gonos E (2002). "Correlation of MDR-1, nm23-H1 and H Sema E gene expression with histopathological findings and clinical outcome in ovarian and breast cancer patients". Anticancer Research. 22 (4): 2275–80. PMID 12174914.
Rieger J, Wick W, Weller M (June 2003). "Human malignant glioma cells express semaphorins and their receptors, neuropilins and plexins". Glia. 42 (4): 379–89. doi:10.1002/glia.10210. PMID 12730958. S2CID 45643250.
Miller LE, Weidler C, Falk W, Angele P, Schaumburger J, Schölmerich J, Straub RH (April 2004). "Increased prevalence of semaphorin 3C, a repellent of sympathetic nerve fibers, in the synovial tissue of patients with rheumatoid arthritis". Arthritis and Rheumatism. 50 (4): 1156–63. doi:10.1002/art.20110. PMID 15077297.
Beckers J, Herrmann F, Rieger S, Drobyshev AL, Horsch M, Hrabé de Angelis M, Seliger B (April 2005). "Identification and validation of novel ERBB2 (HER2, NEU) targets including genes involved in angiogenesis". International Journal of Cancer. 114 (4): 590–7. doi:10.1002/ijc.20798. PMID 15609325. S2CID 39883399.
Herman JG, Meadows GG (May 2007). "Increased class 3 semaphorin expression modulates the invasive and adhesive properties of prostate cancer cells". International Journal of Oncology. 30 (5): 1231–8. doi:10.3892/ijo.30.5.1231. PMID 17390026.

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