SEMA4B

SEMA4B

Identifiers

SEMA4B, SEMAC, SemC, semaphorin 4B

External IDs

OMIM: 617029; MGI: 107559; GeneCards: SEMA4B

Gene location (Human)

Chr.	Chromosome 15 (human)

Band	15q26.1	Start	90,160,604 bp
Band	15q26.1	End	90,229,679 bp

Gene location (Mouse)

Chr.	Chromosome 7 (mouse)

Band	7\|7 D2	Start	79,836,589 bp
Band	7\|7 D2	End	79,876,275 bp

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

mucosa of ileum

mucosa of esophagus

secondary oocyte

muscle layer of sigmoid colon

olfactory zone of nasal mucosa

gums

vagina

transverse colon

gingival epithelium

right lobe of thyroid gland

Top expressed in

cumulus cell

external carotid artery

submandibular gland

ciliary body

internal carotid artery

lumbar spinal ganglion

lip

Rostral migratory stream

yolk sac

blood

More reference expression data

n/a

Gene ontology
Molecular function	neuropilin binding semaphorin receptor binding chemorepellent activity
Cellular component	integral component of membrane membrane extracellular space plasma membrane integral component of plasma membrane
Biological process	multicellular organism development cell differentiation nervous system development negative chemotaxis neural crest cell migration positive regulation of cell migration negative regulation of axon extension involved in axon guidance semaphorin-plexin signaling pathway
Sources:Amigo / QuickGO

Databases

NCBI: entry; OMA: entry

Species

Human

Mouse


10509


20352


ENSG00000185033


ENSMUSG00000030539


Q9NPR2


Q62179

RefSeq (mRNA)

NM_020210 NM_198925 NM_001324029 NM_001324030 NM_001324031
NM_001324032 NM_001324034 NM_001393916


NM_013659 NM_001360135

RefSeq (protein)

NP_001310958 NP_001310959 NP_001310960 NP_001310961 NP_001310962
NP_001310963 NP_064595 NP_945119


NP_038687 NP_001347064

Location (UCSC)

Chr 15: 90.16 – 90.23 Mb

Chr 7: 79.84 – 79.88 Mb

PubMed search

View/Edit Human

View/Edit Mouse

Semaphorin-4B is a protein that in humans is encoded by the SEMA4B gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000185033 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000030539 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Puschel AW, Adams RH, Betz H (Jun 1995). "Murine semaphorin D/collapsin is a member of a diverse gene family and creates domains inhibitory for axonal extension". Neuron. 14 (5): 941–8. doi:10.1016/0896-6273(95)90332-1. PMID 7748561.
↑ "Entrez Gene: SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B".

Further reading

Nagase T, Kikuno R, Hattori A, et al. (2001). "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (6): 347–55. doi:10.1093/dnares/7.6.347. PMID 11214970.
Swiercz JM, Kuner R, Behrens J, Offermanns S (2002). "Plexin-B1 directly interacts with PDZ-RhoGEF/LARG to regulate RhoA and growth cone morphology". Neuron. 35 (1): 51–63. doi:10.1016/S0896-6273(02)00750-X. PMID 12123608.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Liu T, Qian WJ, Gritsenko MA, et al. (2006). "Human Plasma N-Glycoproteome Analysis by Immunoaffinity Subtraction, Hydrazide Chemistry, and Mass Spectrometry". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMC 1850943. PMID 16335952.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.

This article on a gene on human chromosome 15 is a stub. You can help Wikipedia by adding missing information.