SENP8

SENP8
Identifiers
Aliases	SENP8, DEN1, NEDP1, PRSC2, SUMO/sentrin peptidase family member, NEDD8 specific, SUMO peptidase family member, NEDD8 specific
External IDs	OMIM: 608659; MGI: 1918849; GeneCards: SENP8
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1XT9, 2BKQ, 2BKR
Gene location (Human)
Chr.	Chromosome 15 (human)
End	72,143,692 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	59,657,993 bp
RNA expression pattern
	Top expressed in
	sperm; ; gonad; ; secondary oocyte; ; testicle; ; right testis; ; left testis; ; muscle of thigh; ; islet of Langerhans; ; gastrocnemius muscle; ; ventricular zone;
	Top expressed in
	secondary oocyte; ; zygote; ; primary oocyte; ; lumbar spinal ganglion; ; genital tubercle; ; tail of embryo; ; hand; ; otolith organ; ; facial motor nucleus; ; utricle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	peptidase activity; cysteine-type peptidase activity; hydrolase activity; NEDD8-specific protease activity; endopeptidase activity;
Cellular component	cytosol; nucleus;
Biological process	proteolysis; protein deubiquitination; protein desumoylation; post-translational protein modification;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	123228
	71599
	ENSG00000166192
	ENSMUSG00000051705
	Q96LD8
	Q9D2Z4
	NM_001166340; NM_001172109; NM_001172110; NM_001172111; NM_145204
	NM_001172068; NM_001172069; NM_001172070; NM_001172071; NM_027838
	NP_001159812; NP_001165580; NP_001165581; NP_001165582; NP_660205
	NP_001165539; NP_001165540; NP_001165541; NP_001165542; NP_082114
	Wikidata
View/Edit Human	View/Edit Mouse

Sentrin-specific protease 8 is an enzyme that in humans is encoded by the SENP8 gene.

NEDD8 (MIM 603171) is a ubiquitin-like protein that becomes conjugated to the cullin (see CUL1; MIM 603134) subunit of several ubiquitin ligases. This conjugation, called neddylation, is required for optimal ubiquitin ligase activity. NEDD8-specific deneddylases, such as NEDP1, or DEN1, are required to process the NEDD8 propeptide at a C-terminal diglycine motif and to remove NEDD8 from cullins (Gan-Erdene et al., 2003).[supplied by OMIM]