Selenophosphate synthetase 1

SEPHS1
Identifiers
Aliases	SEPHS1, SELD, SPS, SPS1, Selenophosphate synthetase 1
External IDs	OMIM: 600902; MGI: 1923580; GeneCards: SEPHS1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3FD5, 3FD6
Enzyme activity
Gene location (Human)
Chr.	Chromosome 10 (human)
End	13,348,298 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	4,910,557 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; ganglionic eminence; ; islet of Langerhans; ; buccal mucosa cell; ; oocyte; ; olfactory zone of nasal mucosa; ; secondary oocyte; ; rectum; ; internal globus pallidus; ; right lobe of liver;
	Top expressed in
	genital tubercle; ; tail of embryo; ; ventricular zone; ; maxillary prominence; ; mandibular prominence; ; condyle; ; ganglionic eminence; ; abdominal wall; ; primitive streak; ; internal carotid artery;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; selenide, water dikinase activity; GTP binding; protein binding; ATP binding; protein homodimerization activity; identical protein binding; protein heterodimerization activity; kinase activity;
Cellular component	cytoplasm; plasma membrane; nuclear membrane; membrane; nucleus;
Biological process	phosphorylation; selenocysteine biosynthetic process; selenium compound metabolic process; tRNA seleno-modification;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	22929
	109079
	ENSG00000086475
	ENSMUSG00000026662
	P49903; Q5T5U7
	Q8BH69
	NM_001195602; NM_001195604; NM_012247; NM_001375769; NM_001375770
	NM_175400
	NP_001182531; NP_001182533; NP_036379; NP_001362698
	NP_780609; NP_001349636; NP_001349637; NP_001349638; NP_001349639
	Wikidata
View/Edit Human	View/Edit Mouse

Selenide, water dikinase 1 is an enzyme that in humans is encoded by the SEPHS1 gene.

This protein functions as an enzyme that synthesizes selenophosphate from selenide and ATP. Selenophosphate is the selenium donor used to synthesize selenocysteine, which is co-translationally incorporated into selenoproteins at in-frame UGA codons.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000086475 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026662 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Low SC; Harney JW; Berry MJ (Oct 1995). "Cloning and functional characterization of human selenophosphate synthetase, an essential component of selenoprotein synthesis". J Biol Chem. 270 (37): 21659–64. doi:10.1074/jbc.270.37.21659. PMID 7665581.
1 2 "Entrez Gene: SEPHS1 selenophosphate synthetase 1".

Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Tamura T, Yamamoto S, Takahata M, et al. (2004). "Selenophosphate synthetase genes from lung adenocarcinoma cells: Sps1 for recycling L-selenocysteine and Sps2 for selenite assimilation". Proc. Natl. Acad. Sci. U.S.A. 101 (46): 16162–7. Bibcode:2004PNAS..10116162T. doi:10.1073/pnas.0406313101. PMC 528966. PMID 15534230.
Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Saiki R, Nagata A, Kainou T, et al. (2005). "Characterization of solanesyl and decaprenyl diphosphate synthases in mice and humans". FEBS J. 272 (21): 5606–22. doi:10.1111/j.1742-4658.2005.04956.x. PMID 16262699. S2CID 13735213.
Chung HJ, Yoon SI, Shin SH, et al. (2006). "p53-Mediated enhancement of radiosensitivity by selenophosphate synthetase 1 overexpression". J. Cell. Physiol. 209 (1): 131–41. doi:10.1002/jcp.20714. PMID 16786570. S2CID 24313890.

This article on a gene on human chromosome 10 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000086475 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026662 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7665581-5] Low SC; Harney JW; Berry MJ (Oct 1995). "Cloning and functional characterization of human selenophosphate synthetase, an essential component of selenoprotein synthesis". J Biol Chem. 270 (37): 21659–64. doi:10.1074/jbc.270.37.21659. PMID 7665581.

[entrez-6] 1 2 "Entrez Gene: SEPHS1 selenophosphate synthetase 1".

Selenophosphate synthetase 1

See also

References

Further reading