SESN1

SESN1
Identifiers
Aliases	SESN1, PA26, SEST1, sestrin 1
External IDs	OMIM: 606103; MGI: 2155278; GeneCards: SESN1
Gene location (Human)
Chr.	Chromosome 6 (human)
End	109,094,846 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	41,784,420 bp
RNA expression pattern
	Top expressed in
	Skeletal muscle tissue of rectus abdominis; ; muscle of thigh; ; thoracic diaphragm; ; glutes; ; gastrocnemius muscle; ; muscle of arm; ; biceps brachii; ; Skeletal muscle tissue of biceps brachii; ; triceps brachii muscle; ; right ovary;
	Top expressed in
	myocardium of ventricle; ; intercostal muscle; ; conjunctival fornix; ; ciliary body; ; cerebellar vermis; ; interventricular septum; ; iris; ; lobe of cerebellum; ; retinal pigment epithelium; ; vestibular membrane of cochlear duct;
	More reference expression data
	n/a
Gene ontology
Molecular function	oxidoreductase activity; peroxiredoxin activity; protein binding; leucine binding; oxidoreductase activity, acting on peroxide as acceptor;
Cellular component	cytosol; cytoplasm; GATOR2 complex; nucleus; fibrillar center; TORC2 complex;
Biological process	regulation of response to reactive oxygen species; reactive oxygen species metabolic process; cellular oxidant detoxification; negative regulation of TORC1 signaling; cellular response to amino acid starvation; cellular response to glucose starvation; positive regulation of macroautophagy; cellular response to amino acid stimulus; cellular response to leucine; cellular response to leucine starvation;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	27244
	140742
	ENSG00000080546
	ENSMUSG00000038332
	Q9Y6P5
	P58006
	NM_014454; NM_001199933; NM_001199934
	NM_001013370; NM_001162908
	NP_001186862; NP_001186863; NP_055269
	NP_001013388; NP_001156380
	Wikidata
View/Edit Human	View/Edit Mouse

Sestrin 1, also known as p53-regulated protein PA26, is a protein that in humans is encoded by the SESN1 gene. This gene encodes a member of the sestrin family. Sestrins are induced by the p53 tumor suppressor protein and play a role in the cellular response to DNA damage and oxidative stress. The encoded protein mediates p53 inhibition of cell growth by activating AMP-activated protein kinase, which results in the inhibition of the mammalian target of rapamycin protein. The encoded protein also plays a critical role in antioxidant defense by regenerating overoxidized peroxiredoxins, and the expression of this gene is a potential marker for exposure to radiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000080546 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000038332 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: sestrin 1".
↑ Buckbinder L, Talbott R, Seizinger BR, Kley N (October 1994). "Gene regulation by temperature-sensitive p53 mutants: identification of p53 response genes". Proceedings of the National Academy of Sciences of the United States of America. 91 (22): 10640–4. Bibcode:1994PNAS...9110640B. doi:10.1073/pnas.91.22.10640. PMC 45077. PMID 7938006.
↑ Velasco-Miguel S, Buckbinder L, Jean P, Gelbert L, Talbott R, Laidlaw J, Seizinger B, Kley N (January 1999). "PA26, a novel target of the p53 tumor suppressor and member of the GADD family of DNA damage and growth arrest inducible genes". Oncogene. 18 (1): 127–37. doi:10.1038/sj.onc.1202274. PMID 9926927.

Budanov AV, Sablina AA, Feinstein E, Koonin EV, Chumakov PM (April 2004). "Regeneration of peroxiredoxins by p53-regulated sestrins, homologs of bacterial AhpD". Science. 304 (5670): 596–600. Bibcode:2004Sci...304..596B. doi:10.1126/science.1095569. PMID 15105503. S2CID 27871118.
Peeters H, Debeer P, Bairoch A, Wilquet V, Huysmans C, Parthoens E, Fryns JP, Gewillig M, Nakamura Y, Niikawa N, Van de Ven W, Devriendt K (May 2003). "PA26 is a candidate gene for heterotaxia in humans: identification of a novel PA26-related gene family in human and mouse". Human Genetics. 112 (5–6): 573–80. doi:10.1007/s00439-003-0917-5. PMID 12607115. S2CID 22257894.
Jing Y, Zuo Y, Sun L, Yu ZR, Ma S, Hu H, Zhao Q, Huang D, Zhang W, Belmonte JC, Yu Y, Qu J, Liu GH, Wang S (2023). "SESN1 is a FOXO3 effector that counteracts human skeletal muscle ageing". Cell Prolif. 56 (5) e13455. doi:10.1111/cpr.13455. PMC 10212707. PMID 37199024.

This article on a gene on human chromosome 6 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000080546 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000038332 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: sestrin 1".

[pmid7938006-6] Buckbinder L, Talbott R, Seizinger BR, Kley N (October 1994). "Gene regulation by temperature-sensitive p53 mutants: identification of p53 response genes". Proceedings of the National Academy of Sciences of the United States of America. 91 (22): 10640–4. Bibcode:1994PNAS...9110640B. doi:10.1073/pnas.91.22.10640. PMC 45077. PMID 7938006.

[pmid9926927-7] Velasco-Miguel S, Buckbinder L, Jean P, Gelbert L, Talbott R, Laidlaw J, Seizinger B, Kley N (January 1999). "PA26, a novel target of the p53 tumor suppressor and member of the GADD family of DNA damage and growth arrest inducible genes". Oncogene. 18 (1): 127–37. doi:10.1038/sj.onc.1202274. PMID 9926927.

SESN1

See also

References

Further reading