SEZ6L

SEZ6L

Identifiers

SEZ6L, seizure related 6 homolog like

External IDs

OMIM: 607021; MGI: 1935121; GeneCards: SEZ6L

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2YRA

Gene location (Human)

Chr.	Chromosome 22 (human)

Band	22q12.1	Start	26,169,462 bp
Band	22q12.1	End	26,383,597 bp

Gene location (Mouse)

Chr.	Chromosome 5 (mouse)

Band	5\|5 F	Start	112,567,017 bp
Band	5\|5 F	End	112,725,051 bp

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

ganglionic eminence

endothelial cell

lateral nuclear group of thalamus

ventricular zone

prefrontal cortex

buccal mucosa cell

dorsolateral prefrontal cortex

Region I of hippocampus proper

cingulate gyrus

anterior cingulate cortex

Top expressed in

dentate gyrus of hippocampal formation granule cell

CA3 field

entorhinal cortex

primary visual cortex

perirhinal cortex

superior frontal gyrus

nucleus of stria terminalis

cerebellar cortex

hippocampus proper

lateral septal nucleus

More reference expression data


More reference expression data

Databases

NCBI: entry; OMA: entry

Species

Human

Mouse


23544


56747


ENSG00000100095


ENSMUSG00000058153


Q9BYH1


Q6P1D5

RefSeq (mRNA)

NM_001184773 NM_001184774 NM_001184775 NM_001184776 NM_001184777
NM_021115


NM_001253916 NM_001253917 NM_019982

RefSeq (protein)

NP_001171702 NP_001171703 NP_001171704 NP_001171705 NP_001171706
NP_066938 NP_001171704.1

NP_001240845 NP_001240846 NP_064366 NP_001390215 NP_001390216
NP_001390217 NP_001390218

Location (UCSC)

Chr 22: 26.17 – 26.38 Mb

Chr 5: 112.57 – 112.73 Mb

PubMed search

View/Edit Human

View/Edit Mouse

Seizure 6-like protein is a protein that in humans is encoded by the SEZ6L gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000100095 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000058153 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: SEZ6L seizure related 6 homolog (mouse)-like".

Further reading

Gorlov IP, Meyer P, Liloglou T, et al. (2007). "Seizure 6-like (SEZ6L) gene and risk for lung cancer". Cancer Res. 67 (17): 8406–11. doi:10.1158/0008-5472.CAN-06-4784. PMID 17804757.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
Collins JE, Goward ME, Cole CG, et al. (2003). "Reevaluating Human Gene Annotation: A Second-Generation Analysis of Chromosome 22". Genome Res. 13 (1): 27–36. doi:10.1101/gr.695703. PMC 430954. PMID 12529303.
Suzuki H, Gabrielson E, Chen W, et al. (2002). "A genomic screen for genes upregulated by demethylation and histone deacetylase inhibition in human colorectal cancer". Nat. Genet. 31 (2): 141–9. doi:10.1038/ng892. PMID 11992124. S2CID 3038484.
Nishioka M, Kohno T, Takahashi M, et al. (2001). "Identification of a 428-kb homozygously deleted region disrupting the SEZ6L gene at 22q12.1 in a lung cancer cell line". Oncogene. 19 (54): 6251–60. doi:10.1038/sj.onc.1204031. PMID 11175339.
Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi:10.1038/990031. PMID 10591208.
Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (1): 63–70. doi:10.1093/dnares/6.1.63. PMID 10231032.

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