SF3B6

SF3B6
Identifiers
Aliases	SF3B6, HSPC175, Ht006, P14, SAP14, SAP14a, SF3B14, SF3B14a, CGI-110, splicing factor 3b subunit 6
External IDs	OMIM: 607835; MGI: 1913305; GeneCards: SF3B6
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2F9D, 2F9J, 2FHO, 3LQV
Gene location (Human) Chr. Chromosome 2 (human) Band 2p23.3 Start 24,067,586 bp End 24,076,373 bp
Gene location (Mouse) Chr. Chromosome 12 (mouse) Band 12|12 A1.1 Start 4,867,544 bp End 4,877,659 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of arm mucosa of ileum olfactory zone of nasal mucosa Achilles tendon mucosa of sigmoid colon ganglionic eminence cartilage tissue islet of Langerhans rectum tibialis anterior muscle Top expressed in saccule otic placode otic vesicle medial ganglionic eminence transitional epithelium of urinary bladder migratory enteric neural crest cell abdominal wall cervix endocardial cushion ventricular zone More reference expression data BioGPS n/a
Gene ontology Molecular function nucleic acid binding RNA binding protein binding mRNA binding Cellular component catalytic step 2 spliceosome U12-type spliceosomal complex U2-type spliceosomal complex precatalytic spliceosome nucleus U2 snRNP nucleoplasm spliceosomal complex Biological process mRNA splicing, via spliceosome mRNA processing blastocyst formation RNA splicing Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 51639 66055 Ensembl ENSG00000115128 ENSMUSG00000037361 UniProt Q9Y3B4 P59708 RefSeq (mRNA) NM_016047 NM_025323 RefSeq (protein) NP_057131 NP_079599 Location (UCSC) Chr 2: 24.07 – 24.08 Mb Chr 12: 4.87 – 4.88 Mb PubMed search
Wikidata
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Splicing factor 3B subunit 6, is a protein encoded by SF3B6 gene in vertebrates.

Function

This gene encodes a 14 kDa protein subunit of the splicing factor 3b complex. Splicing factor 3b associates with both the U2 and U11/U12 small nuclear ribonucleoprotein complexes (U2 snRNP) of spliceosomes. This 14 kDa protein interacts directly with subunit 1 of the splicing factor 3b complex. This 14 kDa protein also interacts directly with the adenosine that carries out the first transesterification step of splicing at the pre-mRNA branch site.

Interactions

SF3B14 has been shown to interact with SF3B1.