SFMBT1

SFMBT1
Identifiers
Aliases	SFMBT1, RU1, SFMBT, hSFMBT, Scm-like with four mbt domains 1, Scm like with four mbt domains 1
External IDs	OMIM: 607319; MGI: 1859609; GeneCards: SFMBT1
Gene location (Human)
Chr.	Chromosome 3 (human)
End	53,046,750 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	30,544,678 bp
RNA expression pattern
	Top expressed in
	sperm; ; sural nerve; ; oocyte; ; left testis; ; secondary oocyte; ; right testis; ; testicle; ; gonad; ; gastrocnemius muscle; ; islet of Langerhans;
	Top expressed in
	zygote; ; secondary oocyte; ; primary oocyte; ; spermatid; ; spermatocyte; ; supraoptic nucleus; ; yolk sac; ; renal corpuscle; ; ascending aorta; ; aortic valve;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; transcription corepressor activity; histone binding;
Cellular component	nucleus; nucleoplasm;
Biological process	negative regulation of muscle organ development; cell differentiation; negative regulation of transcription, DNA-templated; regulation of transcription, DNA-templated; transcription, DNA-templated; spermatogenesis; chromatin organization;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	51460
	54650
	ENSG00000163935
	ENSMUSG00000006527
	Q9UHJ3
	Q9JMD1
	NM_001005158; NM_001005159; NM_016329
	NM_001166531; NM_001166532; NM_019460; NM_175254
	NP_057413
	NP_001160003; NP_001160004; NP_062333
	Wikidata
View/Edit Human	View/Edit Mouse

Scm-like with four mbt domains 1 is a protein that in humans is encoded by the SFMBT1 gene.

Function

This gene shares high similarity with the Drosophila Scm (sex comb on midleg) gene. It encodes a protein which contains four malignant brain tumor repeat (mbt) domains and may be involved in antigen recognition. [provided by RefSeq, Jun 2012].^{[citation needed]} It encodes a transcriptional repressor protein. The SFMBT1 protein's interaction with cancers is unclear, but elevated levels have been recorded in some renal cancers.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000163935 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000006527 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: Scm-like with four mbt domains 1". Retrieved 2013-11-22.
↑ Wu S, Trievel RC, Rice JC (July 2007). "Human SFMBT is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3". FEBS Letters. 581 (17): 3289–3296. Bibcode:2007FEBSL.581.3289W. doi:10.1016/j.febslet.2007.06.025. PMC 2045647. PMID 17599839.
↑ "SCM-like protein with 4 MBT domains 1; SFMBT1". Online Mendelian Inheritance in Man (OMIM). 2024-12-10. Retrieved 2024-12-10.
↑ Liu X, Simon JM, Xie H, Hu L, Wang J, Zurlo G, et al. (March 2020). "Genome-wide Screening Identifies SFMBT1 as an Oncogenic Driver in Cancer with VHL Loss". Molecular Cell. 77 (6): 1294–1306.e5. doi:10.1016/j.molcel.2020.01.009. PMC 7093231. PMID 32023483.

Zhang J, Bonasio R, Strino F, Kluger Y, Holloway JK, Modzelewski AJ, et al. (April 2013). "SFMBT1 functions with LSD1 to regulate expression of canonical histone genes and chromatin-related factors". Genes & Development. 27 (7): 749–766. doi:10.1101/gad.210963.112. PMC 3639416. PMID 23592795.
Köttgen A, Albrecht E, Teumer A, Vitart V, Krumsiek J, Hundertmark C, et al. (February 2013). "Genome-wide association analyses identify 18 new loci associated with serum urate concentrations". Nature Genetics. 45 (2): 145–154. doi:10.1038/ng.2500. PMC 3663712. PMID 23263486.
Kato T, Sato H, Emi M, Seino T, Arawaka S, Iseki C, et al. (2011). "Segmental copy number loss of SFMBT1 gene in elderly individuals with ventriculomegaly: a community-based study". Internal Medicine. 50 (4). Tokyo, Japan: 297–303. doi:10.2169/internalmedicine.50.4505. PMID 21325761.
Lin S, Shen H, Li JL, Tang S, Gu Y, Chen Z, et al. (March 2013). "Proteomic and functional analyses reveal the role of chromatin reader SFMBT1 in regulating epigenetic silencing and the myogenic gene program". The Journal of Biological Chemistry. 288 (9): 6238–6247. doi:10.1074/jbc.M112.429605. PMC 3585059. PMID 23349461.
Yang HC, Liang YJ, Chen JW, Chiang KM, Chung CM, Ho HY, et al. (2012). Mariño-Ramírez L (ed.). "Identification of IGF1, SLC4A4, WWOX, and SFMBT1 as hypertension susceptibility genes in Han Chinese with a genome-wide gene-based association study". PLOS ONE. 7 (3) e32907. Bibcode:2012PLoSO...732907Y. doi:10.1371/journal.pone.0032907. PMC 3315540. PMID 22479346.
Morel S, Lévy F, Burlet-Schiltz O, Brasseur F, Probst-Kepper M, Peitrequin AL, et al. (January 2000). "Processing of some antigens by the standard proteasome but not by the immunoproteasome results in poor presentation by dendritic cells". Immunity. 12 (1): 107–117. doi:10.1016/S1074-7613(00)80163-6. PMID 10661410.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 3 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000163935 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000006527 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Scm-like with four mbt domains 1". Retrieved 2013-11-22.

[e142-6] Wu S, Trievel RC, Rice JC (July 2007). "Human SFMBT is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3". FEBS Letters. 581 (17): 3289–3296. Bibcode:2007FEBSL.581.3289W. doi:10.1016/j.febslet.2007.06.025. PMC 2045647. PMID 17599839.

[p288-7] "SCM-like protein with 4 MBT domains 1; SFMBT1". Online Mendelian Inheritance in Man (OMIM). 2024-12-10. Retrieved 2024-12-10.

[e669-8] Liu X, Simon JM, Xie H, Hu L, Wang J, Zurlo G, et al. (March 2020). "Genome-wide Screening Identifies SFMBT1 as an Oncogenic Driver in Cancer with VHL Loss". Molecular Cell. 77 (6): 1294–1306.e5. doi:10.1016/j.molcel.2020.01.009. PMC 7093231. PMID 32023483.

SFMBT1

Function

References

Further reading