SFPQ

SFPQ

Identifiers

SFPQ, POMP100, PPP1R140, PSF, splicing factor proline and glutamine rich

External IDs

OMIM: 605199; MGI: 1918764; GeneCards: SFPQ

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
4WII, 4WIJ, 4WIK

Gene location (Human)

Chr.	Chromosome 1 (human)

Band	1p34.3	Start	35,176,378 bp
Band	1p34.3	End	35,193,446 bp

Gene location (Mouse)

Chr.	Chromosome 4 (mouse)

Band	4 D2.2\|4 61.2 cM	Start	127,021,324 bp
Band	4 D2.2\|4 61.2 cM	End	127,037,013 bp

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

tendon of biceps brachii

ventricular zone

ganglionic eminence

right uterine tube

sural nerve

cerebellar hemisphere

right hemisphere of cerebellum

left ovary

right ovary

sperm

Top expressed in

tail of embryo

genital tubercle

ventricular zone

mandibular prominence

Rostral migratory stream

maxillary prominence

epiblast

abdominal wall

ganglionic eminence

neural layer of retina

More reference expression data

n/a

Gene ontology
Molecular function	RNA polymerase II cis-regulatory region sequence-specific DNA binding histone deacetylase binding chromatin binding transcription cis-regulatory region binding protein binding nucleic acid binding DNA binding protein homodimerization activity RNA binding DNA-binding transcription factor activity, RNA polymerase II-specific E-box binding
Cellular component	cytoplasm paraspeckles nuclear matrix RNA polymerase II transcription regulator complex chromatin nucleus nucleoplasm extracellular matrix nuclear speck dendrite cytoplasm
Biological process	histone H3 deacetylation DNA recombination regulation of transcription, DNA-templated rhythmic process negative regulation of circadian rhythm mRNA processing negative regulation of transcription by RNA polymerase II chromosome organization transcription, DNA-templated cellular response to DNA damage stimulus regulation of cell cycle regulation of circadian rhythm double-strand break repair via homologous recombination RNA splicing positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway positive regulation of sister chromatid cohesion negative regulation of transcription, DNA-templated alternative mRNA splicing, via spliceosome DNA repair positive regulation of transcription by RNA polymerase II activation of innate immune response immune system process innate immune response dendritic transport of messenger ribonucleoprotein complex
Sources:Amigo / QuickGO

Databases

NCBI: entry; OMA: entry

Species

Human

Mouse


6421


71514


ENSG00000116560


ENSMUSG00000028820


P23246


Q8VIJ6

RefSeq (mRNA)


NM_005066


NM_023603

RefSeq (protein)


NP_005057


NP_076092

Location (UCSC)

Chr 1: 35.18 – 35.19 Mb

Chr 4: 127.02 – 127.04 Mb

PubMed search

View/Edit Human

View/Edit Mouse

Splicing factor, proline- and glutamine-rich is a protein that in humans is encoded by the SFPQ gene.

Interactions

SFPQ has been shown to interact with PTBP1, NONO, CDC5L and Ubiquitin C.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000116560 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028820 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 Patton JG, Porro EB, Galceran J, Tempst P, Nadal-Ginard B (Mar 1993). "Cloning and characterization of PSF, a novel pre-mRNA splicing factor". Genes & Development. 7 (3): 393–406. doi:10.1101/gad.7.3.393. PMID 8449401.
↑ "Entrez Gene: SFPQ splicing factor proline/glutamine-rich (polypyrimidine tract binding protein associated)".
↑ Meissner M, Dechat T, Gerner C, Grimm R, Foisner R, Sauermann G (Jan 2000). "Differential nuclear localization and nuclear matrix association of the splicing factors PSF and PTB". Journal of Cellular Biochemistry. 76 (4): 559–66. doi:10.1002/(SICI)1097-4644(20000315)76:4<559::AID-JCB4>3.0.CO;2-U. PMID 10653975. S2CID 25669908.
↑ Peng R, Dye BT, Pérez I, Barnard DC, Thompson AB, Patton JG (Oct 2002). "PSF and p54nrb bind a conserved stem in U5 snRNA". RNA. 8 (10): 1334–47. doi:10.1017/S1355838202022070. PMC 1370341. PMID 12403470.
↑ Ajuh P, Kuster B, Panov K, Zomerdijk JC, Mann M, Lamond AI (Dec 2000). "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry". The EMBO Journal. 19 (23): 6569–81. doi:10.1093/emboj/19.23.6569. PMC 305846. PMID 11101529.
↑ Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (Sep 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.

Further reading

Shav-Tal Y, Zipori D (Nov 2002). "PSF and p54(nrb)/NonO--multi-functional nuclear proteins". FEBS Letters. 531 (2): 109–14. doi:10.1016/S0014-5793(02)03447-6. PMID 12417296. S2CID 12485304.
Gower HJ, Moore SE, Dickson G, Elsom VL, Nayak R, Walsh FS (Apr 1989). "Cloning and characterization of a myoblast cell surface antigen defined by 24.1D5 monoclonal antibody". Development. 105 (4): 723–31. doi:10.1242/dev.105.4.723. PMID 2480877.
Gozani O, Patton JG, Reed R (Jul 1994). "A novel set of spliceosome-associated proteins and the essential splicing factor PSF bind stably to pre-mRNA prior to catalytic step II of the splicing reaction". The EMBO Journal. 13 (14): 3356–67. doi:10.1002/j.1460-2075.1994.tb06638.x. PMC 395233. PMID 8045264.
Zhang WW, Zhang LX, Busch RK, Farrés J, Busch H (Feb 1993). "Purification and characterization of a DNA-binding heterodimer of 52 and 100 kDa from HeLa cells". The Biochemical Journal. 290 (1): 267–72. doi:10.1042/bj2900267. PMC 1132410. PMID 8439294.
Clark J, Lu YJ, Sidhar SK, Parker C, Gill S, Smedley D, Hamoudi R, Linehan WM, Shipley J, Cooper CS (Oct 1997). "Fusion of splicing factor genes PSF and NonO (p54nrb) to the TFE3 gene in papillary renal cell carcinoma". Oncogene. 15 (18): 2233–9. CiteSeerX 10.1.1.462.8435. doi:10.1038/sj.onc.1201394. PMID 9393982. {{cite journal}}: Cite uses deprecated parameter |citeseerx= (help)
Teigelkamp S, Mundt C, Achsel T, Will CL, Lührmann R (Nov 1997). "The human U5 snRNP-specific 100-kD protein is an RS domain-containing, putative RNA helicase with significant homology to the yeast splicing factor Prp28p". RNA. 3 (11): 1313–26. PMC 1369570. PMID 9409622.
Straub T, Grue P, Uhse A, Lisby M, Knudsen BR, Tange TO, Westergaard O, Boege F (Oct 1998). "The RNA-splicing factor PSF/p54 controls DNA-topoisomerase I activity by a direct interaction". The Journal of Biological Chemistry. 273 (41): 26261–4. doi:10.1074/jbc.273.41.26261. PMID 9756848.
Lutz CS, Cooke C, O'Connor JP, Kobayashi R, Alwine JC (Dec 1998). "The snRNP-free U1A (SF-A) complex(es): identification of the largest subunit as PSF, the polypyrimidine-tract binding protein-associated splicing factor". RNA. 4 (12): 1493–9. doi:10.1017/S1355838298981183. PMC 1369720. PMID 9848648.
Meissner M, Dechat T, Gerner C, Grimm R, Foisner R, Sauermann G (Jan 2000). "Differential nuclear localization and nuclear matrix association of the splicing factors PSF and PTB". Journal of Cellular Biochemistry. 76 (4): 559–66. doi:10.1002/(SICI)1097-4644(20000315)76:4<559::AID-JCB4>3.0.CO;2-U. PMID 10653975. S2CID 25669908.
Urban RJ, Bodenburg Y, Kurosky A, Wood TG, Gasic S (Jun 2000). "Polypyrimidine tract-binding protein-associated splicing factor is a negative regulator of transcriptional activity of the porcine p450scc insulin-like growth factor response element". Molecular Endocrinology. 14 (6): 774–82. doi:10.1210/mend.14.6.0485. PMID 10847580.
Straub T, Knudsen BR, Boege F (Jun 2000). "PSF/p54(nrb) stimulates "jumping" of DNA topoisomerase I between separate DNA helices". Biochemistry. 39 (25): 7552–8. doi:10.1021/bi992898e. PMID 10858305.
Akhmedov AT, Lopez BS (Aug 2000). "Human 100-kDa homologous DNA-pairing protein is the splicing factor PSF and promotes DNA strand invasion". Nucleic Acids Research. 28 (16): 3022–30. doi:10.1093/nar/28.16.3022. PMC 108454. PMID 10931916.
de Vries H, Rüegsegger U, Hübner W, Friedlein A, Langen H, Keller W (Nov 2000). "Human pre-mRNA cleavage factor II(m) contains homologs of yeast proteins and bridges two other cleavage factors". The EMBO Journal. 19 (21): 5895–904. doi:10.1093/emboj/19.21.5895. PMC 305781. PMID 11060040.
Dye BT, Patton JG (Feb 2001). "An RNA recognition motif (RRM) is required for the localization of PTB-associated splicing factor (PSF) to subnuclear speckles". Experimental Cell Research. 263 (1): 131–44. doi:10.1006/excr.2000.5097. PMID 11161712.
Mathur M, Tucker PW, Samuels HH (Apr 2001). "PSF is a novel corepressor that mediates its effect through Sin3A and the DNA binding domain of nuclear hormone receptors". Molecular and Cellular Biology. 21 (7): 2298–311. doi:10.1128/MCB.21.7.2298-2311.2001. PMC 86864. PMID 11259580.
Shav-Tal Y, Cohen M, Lapter S, Dye B, Patton JG, Vandekerckhove J, Zipori D (Aug 2001). "Nuclear relocalization of the pre-mRNA splicing factor PSF during apoptosis involves hyperphosphorylation, masking of antigenic epitopes, and changes in protein interactions". Molecular Biology of the Cell. 12 (8): 2328–40. doi:10.1091/mbc.12.8.2328. PMC 58597. PMID 11514619.
Zhang Z, Carmichael GG (Aug 2001). "The fate of dsRNA in the nucleus: a p54(nrb)-containing complex mediates the nuclear retention of promiscuously A-to-I edited RNAs". Cell. 106 (4): 465–75. doi:10.1016/S0092-8674(01)00466-4. PMID 11525732. S2CID 18799711.
Andersen JS, Lyon CE, Fox AH, Leung AK, Lam YW, Steen H, Mann M, Lamond AI (Jan 2002). "Directed proteomic analysis of the human nucleolus". Current Biology. 12 (1): 1–11. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298. S2CID 14132033.
Sewer MB, Nguyen VQ, Huang CJ, Tucker PW, Kagawa N, Waterman MR (Apr 2002). "Transcriptional activation of human CYP17 in H295R adrenocortical cells depends on complex formation among p54(nrb)/NonO, protein-associated splicing factor, and SF-1, a complex that also participates in repression of transcription". Endocrinology. 143 (4): 1280–90. doi:10.1210/endo.143.4.8748. PMID 11897684.

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