SREK1

SREK1
Identifiers
Aliases	SREK1, SFRS12, SRrp508, SRrp86, splicing regulatory glutamic acid/lysine-rich protein 1, splicing regulatory glutamic acid and lysine rich protein 1
External IDs	OMIM: 609268; MGI: 2145245; GeneCards: SREK1
Gene location (Human)
Chr.	Chromosome 5 (human)
End	66,183,615 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	103,911,116 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; Achilles tendon; ; right uterine tube; ; corpus epididymis; ; ventricular zone; ; caput epididymis; ; body of pancreas; ; left lobe of thyroid gland; ; right lobe of thyroid gland; ; body of uterus;
	Top expressed in
	genital tubercle; ; tail of embryo; ; Rostral migratory stream; ; neural layer of retina; ; yolk sac; ; zygote; ; pineal gland; ; medullary collecting duct; ; ventricular zone; ; lens;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; nucleic acid binding; RNA binding;
Cellular component	spliceosomal complex; nucleus; nucleoplasm; nuclear speck;
Biological process	mRNA processing; RNA splicing; regulation of alternative mRNA splicing, via spliceosome;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	140890
	218543
	ENSG00000153914
	ENSMUSG00000032621
	Q8WXA9
	Q8BZX4
NM_001077199; NM_001270492; NM_001270493; NM_139168; NM_001323527;
	NM_001323529; NM_001323533; NM_001323534; NM_001323535
	NM_172592; NM_001361085
NP_001070667; NP_001257421; NP_001310456; NP_001310458; NP_001310462;
	NP_001310463; NP_001310464; NP_631907
	NP_766180; NP_001348014
	Wikidata
View/Edit Human	View/Edit Mouse

Splicing regulatory glutamine/lysine-rich protein 1 is a protein that in humans is encoded by the SREK1 gene (previously SFRS12). The SREK1 protein has been predicted to regulate alternative splicing through its interaction with other splice factors (modulating splice site selection). In particular, it is predicted to inhibit SFRS1, SFRS2, and SFRS6, while promoting the splicing activity of SFRS3.

SREK1/SFRS12 belongs to the superfamily of serine/arginine-rich (SR) splicing factors.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000153914 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000032621 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Zhang DL, Sun XJ, Ling LJ, Chen RS, Ma DL (Jun 2002). "[Molecular cloning, characterization, chromosomal assignment, genomic organization and verification of SFRS12(SRrp508), a novel member of human SR protein superfamily and a human homolog of rat SRrp86]". Yi Chuan Xue Bao. 29 (5): 377–83. PMID 12043562.
1 2 3 "Entrez Gene: SFRS12 splicing factor, arginine/serine-rich 12".
1 2 "Q8WXA9 · SREK1_HUMAN". uniprot.org. UniProt consortium. Retrieved 2026-08-25.

Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Heese K, Fujita M, Akatsu H, et al. (2005). "The splicing regulatory protein p18SRP is down-regulated in Alzheimer's disease brain". J. Mol. Neurosci. 24 (2): 269–76. doi:10.1385/JMN:24:2:269. PMID 15456940. S2CID 21158144.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Li J, Hawkins IC, Harvey CD, et al. (2003). "Regulation of alternative splicing by SRrp86 and its interacting proteins". Mol. Cell. Biol. 23 (21): 7437–47. doi:10.1128/MCB.23.21.7437-7447.2003. PMC 207616. PMID 14559993.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Peng R, Dye BT, Pérez I, et al. (2002). "PSF and p54nrb bind a conserved stem in U5 snRNA". RNA. 8 (10): 1334–47. doi:10.1017/S1355838202022070. PMC 1370341. PMID 12403470.
Li J, Barnard DC, Patton JG (2002). "A unique glutamic acid-lysine (EK) domain acts as a splicing inhibitor". J. Biol. Chem. 277 (42): 39485–92. doi:10.1074/jbc.M201784200. PMID 12183448.
Rappsilber J, Ryder U, Lamond AI, Mann M (2002). "Large-scale proteomic analysis of the human spliceosome". Genome Res. 12 (8): 1231–45. doi:10.1101/gr.473902. PMC 186633. PMID 12176931.
Barnard DC, Li J, Peng R, Patton JG (2002). "Regulation of alternative splicing by SRrp86 through coactivation and repression of specific SR proteins". RNA. 8 (4): 526–33. doi:10.1017/S1355838202029928. PMC 1370273. PMID 11991645.
Barnard DC, Patton JG (2000). "Identification and characterization of a novel serine-arginine-rich splicing regulatory protein". Mol. Cell. Biol. 20 (9): 3049–57. doi:10.1128/MCB.20.9.3049-3057.2000. PMC 85584. PMID 10757789.

This article on a gene on human chromosome 5 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000153914 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000032621 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12043562-5] Zhang DL, Sun XJ, Ling LJ, Chen RS, Ma DL (Jun 2002). "[Molecular cloning, characterization, chromosomal assignment, genomic organization and verification of SFRS12(SRrp508), a novel member of human SR protein superfamily and a human homolog of rat SRrp86]". Yi Chuan Xue Bao. 29 (5): 377–83. PMID 12043562.

[entrez-6] 1 2 3 "Entrez Gene: SFRS12 splicing factor, arginine/serine-rich 12".

[uniprot-7] 1 2 "Q8WXA9 · SREK1_HUMAN". uniprot.org. UniProt consortium. Retrieved 2026-08-25.

SREK1

References

Further reading