SCAF11

SCAF11
Identifiers
Aliases	SCAF11, CASP11, SFRS2IP, SIP1, SRRP129, SRSF2IP, SR-related CTD associated factor 11
External IDs	OMIM: 603668; MGI: 1919443; GeneCards: SCAF11
Gene location (Human)
Chr.	Chromosome 12 (human)
End	45,992,120 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	96,358,724 bp
RNA expression pattern
	Top expressed in
	buccal mucosa cell; ; epithelium of colon; ; tendon of biceps brachii; ; Achilles tendon; ; lower lobe of lung; ; jejunal mucosa; ; pylorus; ; tonsil; ; oral cavity; ; sural nerve;
	Top expressed in
	tail of embryo; ; genital tubercle; ; mandibular prominence; ; maxillary prominence; ; epithelium of stomach; ; ankle; ; skin of external ear; ; abdominal wall; ; tibiofemoral joint; ; cumulus cell;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; metal ion binding; RNA binding;
Cellular component	nucleolus; nucleus; nucleoplasm; nuclear body;
Biological process	RNA splicing, via transesterification reactions; mRNA processing; spliceosomal complex assembly; RNA splicing;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	9169
	72193
	ENSG00000139218
	ENSMUSG00000033228
	Q99590
	n/a
	NM_004719
	NM_028148
	NP_004710
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

SR-related CTD associated factor 11 is a protein that in humans is encoded by the SCAF11 gene (previously SFRS2IP). This protein is involved in regulating the assembly of the spliceosome.

Interactions

SCAF11 has been shown to interact with U2AF2.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000139218 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000033228 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Tanner S, Stagljar I, Georgiev O, Schaffner W, Bourquin JP (Aug 1997). "A novel SR-related protein specifically interacts with the carboxy-terminal domain (CTD) of RNA polymerase II through a conserved interaction domain". Biol Chem. 378 (6): 565–71. doi:10.1515/bchm.1997.378.6.565. PMID 9224939.
1 2 Zhang WJ, Wu JY (Feb 1998). "Sip1, a novel RS domain-containing protein essential for pre-mRNA splicing". Mol Cell Biol. 18 (2): 676–84. doi:10.1128/mcb.18.2.676. PMC 108778. PMID 9447963.
1 2 "Entrez Gene: SFRS2IP splicing factor, arginine/serine-rich 2, interacting protein".

Gui JF, Lane WS, Fu XD (1994). "A serine kinase regulates intracellular localization of splicing factors in the cell cycle". Nature. 369 (6482): 678–82. Bibcode:1994Natur.369..678G. doi:10.1038/369678a0. PMID 8208298. S2CID 4275539. Archived from the original on 2020-12-03. Retrieved 2019-12-14.
van de Craen M, de Jonghe C, van den Brande I, et al. (1999). "Identification of caspases that cleave presenilin-1 and presenilin-2. Five presenilin-1 (PS1) mutations do not alter the sensitivity of PS1 to caspases" (PDF). FEBS Lett. 445 (1): 149–54. doi:10.1016/S0014-5793(99)00108-8. hdl:10067/238040151162165141. PMID 10069390. S2CID 31218178.
Scanlan MJ, Gordan JD, Williamson B, et al. (1999). "Antigens recognized by autologous antibody in patients with renal-cell carcinoma". Int. J. Cancer. 83 (4): 456–64. doi:10.1002/(SICI)1097-0215(19991112)83:4<456::AID-IJC4>3.0.CO;2-5. PMID 10508479.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.

This article on a gene on human chromosome 12 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000139218 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000033228 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9224939-5] Tanner S, Stagljar I, Georgiev O, Schaffner W, Bourquin JP (Aug 1997). "A novel SR-related protein specifically interacts with the carboxy-terminal domain (CTD) of RNA polymerase II through a conserved interaction domain". Biol Chem. 378 (6): 565–71. doi:10.1515/bchm.1997.378.6.565. PMID 9224939.

[pmid9447963-6] 1 2 Zhang WJ, Wu JY (Feb 1998). "Sip1, a novel RS domain-containing protein essential for pre-mRNA splicing". Mol Cell Biol. 18 (2): 676–84. doi:10.1128/mcb.18.2.676. PMC 108778. PMID 9447963.

[entrez-7] 1 2 "Entrez Gene: SFRS2IP splicing factor, arginine/serine-rich 2, interacting protein".

SCAF11

Interactions

References

Further reading