SFRS9

SRSF9

Identifiers

SRSF9, SFRS9, SRp30c, serine/arginine-rich splicing factor 9, serine and arginine rich splicing factor 9

External IDs

OMIM: 601943; MGI: 104896; GeneCards: SRSF9

Gene location (Human)

Chr.	Chromosome 12 (human)

Band	12q24.31	Start	120,461,672 bp
Band	12q24.31	End	120,469,748 bp

Gene location (Mouse)

Chr.	Chromosome 5 (mouse)

Band	5\|5 F	Start	115,465,236 bp
Band	5\|5 F	End	115,471,139 bp

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

body of pancreas

monocyte

ventricular zone

buccal mucosa cell

right testis

ganglionic eminence

beta cell

palpebral conjunctiva

mucosa of pharynx

right adrenal cortex

Top expressed in

renal corpuscle

Gonadal ridge

epiblast

endocardial cushion

somite

molar

medullary collecting duct

hand

primitive streak

ureter

More reference expression data


More reference expression data

Gene ontology
Molecular function	protein binding nucleic acid binding RNA binding protein domain specific binding
Cellular component	nucleolus nucleus nucleoplasm nuclear speck
Biological process	mRNA splicing, via spliceosome termination of RNA polymerase II transcription mRNA processing negative regulation of mRNA splicing, via spliceosome mRNA splice site selection mRNA export from nucleus mRNA 3'-end processing response to alkaloid RNA export from nucleus RNA splicing response to toxic substance regulation of alternative mRNA splicing, via spliceosome mRNA cis splicing, via spliceosome
Sources:Amigo / QuickGO

Databases

NCBI: entry; OMA: entry

Species

Human

Mouse


8683


108014


ENSG00000111786


ENSMUSG00000029538


Q13242


Q9D0B0

RefSeq (mRNA)


NM_003769


NM_025573

RefSeq (protein)


NP_003760


NP_079849

Location (UCSC)

Chr 12: 120.46 – 120.47 Mb

Chr 5: 115.47 – 115.47 Mb

PubMed search

View/Edit Human

View/Edit Mouse

Splicing factor, arginine/serine-rich 9, also known as SFRS9, is a human gene encoding an SR protein involved in splice site selection in alternative splicing.

Interactions

SFRS9 has been shown to interact with Y box binding protein 1 and NOL3.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000111786 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029538 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: SFRS9 splicing factor, arginine/serine-rich 9".
↑ Raffetseder, Ute; Frye Björn; Rauen Thomas; Jürchott Karsten; Royer Hans-Dieter; Jansen Petra Lynen; Mertens Peter R (May 2003). "Splicing factor SRp30c interaction with Y-box protein-1 confers nuclear YB-1 shuttling and alternative splice site selection". J. Biol. Chem. 278 (20): 18241–8. doi:10.1074/jbc.M212518200. ISSN 0021-9258. PMID 12604611.
↑ Stoss, O; Schwaiger F W; Cooper T A; Stamm S (Apr 1999). "Alternative splicing determines the intracellular localization of the novel nuclear protein Nop30 and its interaction with the splicing factor SRp30c". J. Biol. Chem. 274 (16): 10951–62. doi:10.1074/jbc.274.16.10951. ISSN 0021-9258. PMID 10196175.

Further reading

Screaton GR, Cáceres JF, Mayeda A, et al. (1995). "Identification and characterization of three members of the human SR family of pre-mRNA splicing factors". EMBO J. 14 (17): 4336–49. doi:10.1002/j.1460-2075.1995.tb00108.x. PMC 394518. PMID 7556075.
Nayler O, Strätling W, Bourquin JP, et al. (1998). "SAF-B protein couples transcription and pre-mRNA splicing to SAR/MAR elements". Nucleic Acids Res. 26 (15): 3542–9. doi:10.1093/nar/26.15.3542. PMC 147731. PMID 9671816.
Yuan Y; Li DM; Sun H (1998). "PIR1, a novel phosphatase that exhibits high affinity to RNA . ribonucleoprotein complexes". J. Biol. Chem. 273 (32): 20347–53. doi:10.1074/jbc.273.32.20347. PMID 9685386.
Petersen-Mahrt SK, Estmer C, Ohrmalm C, et al. (1999). "The splicing factor-associated protein, p32, regulates RNA splicing by inhibiting ASF/SF2 RNA binding and phosphorylation". EMBO J. 18 (4): 1014–24. doi:10.1093/emboj/18.4.1014. PMC 1171193. PMID 10022843.
Stoss O; Schwaiger FW; Cooper TA; Stamm S (1999). "Alternative splicing determines the intracellular localization of the novel nuclear protein Nop30 and its interaction with the splicing factor SRp30c". J. Biol. Chem. 274 (16): 10951–62. doi:10.1074/jbc.274.16.10951. PMID 10196175.
Elliott DJ, Bourgeois CF, Klink A, et al. (2000). "A mammalian germ cell-specific RNA-binding protein interacts with ubiquitously expressed proteins involved in splice site selection". Proc. Natl. Acad. Sci. U.S.A. 97 (11): 5717–22. Bibcode:2000PNAS...97.5717E. doi:10.1073/pnas.97.11.5717. PMC 18499. PMID 10823932.
Stoss O, Olbrich M, Hartmann AM, et al. (2001). "The STAR/GSG family protein rSLM-2 regulates the selection of alternative splice sites". J. Biol. Chem. 276 (12): 8665–73. doi:10.1074/jbc.M006851200. PMID 11118435.
Denegri M, Chiodi I, Corioni M, et al. (2002). "Stress-induced nuclear bodies are sites of accumulation of pre-mRNA processing factors". Mol. Biol. Cell. 12 (11): 3502–14. doi:10.1091/mbc.12.11.3502. PMC 60271. PMID 11694584.
Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298. S2CID 14132033.
Young PJ, DiDonato CJ, Hu D, et al. (2002). "SRp30c-dependent stimulation of survival motor neuron (SMN) exon 7 inclusion is facilitated by a direct interaction with hTra2 beta 1". Hum. Mol. Genet. 11 (5): 577–87. doi:10.1093/hmg/11.5.577. PMID 11875052.
Simard MJ; Chabot B (2002). "SRp30c is a repressor of 3' splice site utilization". Mol. Cell. Biol. 22 (12): 4001–10. doi:10.1128/MCB.22.12.4001-4010.2002. PMC 133842. PMID 12024014.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Raffetseder U, Frye B, Rauen T, et al. (2003). "Splicing factor SRp30c interaction with Y-box protein-1 confers nuclear YB-1 shuttling and alternative splice site selection". J. Biol. Chem. 278 (20): 18241–8. doi:10.1074/jbc.M212518200. PMID 12604611.
Xu Q; Leung DY; Kisich KO (2003). "Serine-arginine-rich protein p30 directs alternative splicing of glucocorticoid receptor pre-mRNA to glucocorticoid receptor beta in neutrophils". J. Biol. Chem. 278 (29): 27112–8. doi:10.1074/jbc.M300824200. PMID 12738786.
Li J, Hawkins IC, Harvey CD, et al. (2003). "Regulation of alternative splicing by SRrp86 and its interacting proteins". Mol. Cell. Biol. 23 (21): 7437–47. doi:10.1128/MCB.23.21.7437-7447.2003. PMC 207616. PMID 14559993.
Kondo S, Yamamoto N, Murakami T, et al. (2004). "Tra2 beta, SF2/ASF and SRp30c modulate the function of an exonic splicing enhancer in exon 10 of tau pre-mRNA". Genes Cells. 9 (2): 121–30. doi:10.1111/j.1356-9597.2004.00709.x. PMID 15009090. S2CID 22248867.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Wang Y, Wang J, Gao L, et al. (2005). "Tau exons 2 and 10, which are misregulated in neurodegenerative diseases, are partly regulated by silencers which bind a SRp30c.SRp55 complex that either recruits or antagonizes htra2beta1". J. Biol. Chem. 280 (14): 14230–9. doi:10.1074/jbc.M413846200. PMID 15695522.
Scherer SE, Muzny DM, Buhay CJ, et al. (2006). "The finished DNA sequence of human chromosome 12". Nature. 440 (7082): 346–51. Bibcode:2006Natur.440..346S. doi:10.1038/nature04569. PMID 16541075.

v t e PDB gallery
1wg4: Solution structure of RRM domain in protein BAB31986

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