SFXN4

SFXN4
Identifiers
Aliases	SFXN4, BCRM1, COXPD18, sideroflexin 4, SLC56A4
External IDs	OMIM: 615564; MGI: 2137680; GeneCards: SFXN4
Gene location (Human)
Chr.	Chromosome 10 (human)
End	119,165,714 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	60,849,917 bp
RNA expression pattern
	Top expressed in
	apex of heart; ; tibialis anterior muscle; ; right adrenal cortex; ; body of pancreas; ; muscle of thigh; ; mucosa of transverse colon; ; right uterine tube; ; gastrocnemius muscle; ; left adrenal gland; ; deltoid muscle;
	Top expressed in
	Region I of hippocampus proper; ; neural layer of retina; ; lumbar spinal ganglion; ; facial motor nucleus; ; visual cortex; ; primary visual cortex; ; dentate gyrus of hippocampal formation granule cell; ; superior frontal gyrus; ; suprachiasmatic nucleus; ; dorsal tegmental nucleus;
	More reference expression data
	n/a
Gene ontology
Molecular function	ion transmembrane transporter activity;
Cellular component	integral component of membrane; mitochondrial inner membrane; mitochondrion; membrane; intracellular membrane-bounded organelle;
Biological process	ion transmembrane transport; iron ion homeostasis; ion transport; transmembrane transport; amino acid transport;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	119559
	94281
	ENSG00000183605
	ENSMUSG00000063698
	Q6P4A7
	Q925N1
	NM_178867; NM_213649
	NM_053198; NM_001362384; NM_001362385
	NP_998814
	NP_444428; NP_001349313; NP_001349314
	Wikidata
View/Edit Human	View/Edit Mouse

Sideroflexin-4 is a protein that in humans is encoded by the SFXN4 gene. Sideroflexin-4 is a membrane transporter that belongs to solute carrier family 56. It is associated with mitochondrial transmembrane transport and amino acid transport, where it is required for mitochondrial respiratory homeostasis.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000183605 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000063698 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "SFXN4 Gene - GeneCards". www.genecards.org. Retrieved 2026-10-05.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000183605 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000063698 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] "SFXN4 Gene - GeneCards". www.genecards.org. Retrieved 2026-10-05.