SHC2

SHC2

Identifiers

SHC2, SCK, SHCB, SLI, SHC adaptor protein 2

External IDs

OMIM: 605217; MGI: 106180; GeneCards: SHC2

Gene location (Human)

Chr.	Chromosome 19 (human)

Band	19p13.3	Start	416,589 bp
Band	19p13.3	End	461,033 bp

Gene location (Mouse)

Chr.	Chromosome 10 (mouse)

Band	10 C1\|10 39.72 cM	Start	79,453,885 bp
Band	10 C1\|10 39.72 cM	End	79,473,752 bp

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

body of pancreas

anterior pituitary

right lobe of liver

right uterine tube

gastric mucosa

apex of heart

right frontal lobe

left lobe of thyroid gland

right lobe of thyroid gland

amygdala

Top expressed in

superior cervical ganglion

lumbar spinal ganglion

primary visual cortex

superior frontal gyrus

dentate gyrus of hippocampal formation granule cell

neural tube

genital tubercle

muscle of thigh

tail of embryo

humerus

More reference expression data


More reference expression data

Gene ontology
Molecular function	protein binding receptor tyrosine kinase binding
Cellular component	cytosol plasma membrane cellular component
Biological process	Ras protein signal transduction vascular endothelial growth factor receptor signaling pathway MAPK cascade transmembrane receptor protein tyrosine kinase signaling pathway intracellular signal transduction
Sources:Amigo / QuickGO

Databases

NCBI: entry; OMA: entry

Species

Human

Mouse


25759


216148


ENSG00000129946


ENSMUSG00000020312


P98077


Q8BMC3

RefSeq (mRNA)


NM_012435 NM_001387056


NM_001024539

RefSeq (protein)


NP_036567


NP_001019710

Location (UCSC)

Chr 19: 0.42 – 0.46 Mb

Chr 10: 79.45 – 79.47 Mb

PubMed search

View/Edit Human

View/Edit Mouse

SHC-transforming protein 2 is a protein that in humans is encoded by the SHC2 gene.

Interactions

SHC2 has been shown to interact with Kinase insert domain receptor.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000129946 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000020312 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Kavanaugh WM; Williams LT (Jan 1995). "An alternative to SH2 domains for binding tyrosine-phosphorylated proteins". Science. 266 (5192): 1862–5. Bibcode:1994Sci...266.1862K. doi:10.1126/science.7527937. PMID 7527937.
↑ Nakamura T; Muraoka S; Sanokawa R; Mori N (Apr 1998). "N-Shc and Sck, two neuronally expressed Shc adapter homologs. Their differential regional expression in the brain and roles in neurotrophin and Src signaling". J Biol Chem. 273 (12): 6960–7. doi:10.1074/jbc.273.12.6960. PMID 9507002.
↑ "Entrez Gene: SHC2 SHC (Src homology 2 domain containing) transforming protein 2".
↑ Warner, A J; Lopez-Dee J; Knight E L; Feramisco J R; Prigent S A (Apr 2000). "The Shc-related adaptor protein, Sck, forms a complex with the vascular-endothelial-growth-factor receptor KDR in transfected cells". Biochem. J. 347 (Pt 2). England: 501–9. doi:10.1042/0264-6021:3470501. ISSN 0264-6021. PMC 1220983. PMID 10749680.

Further reading

Choy KW, Wang CC, Ogura A, et al. (2007). "Genomic annotation of 15,809 ESTs identified from pooled early gestation human eyes". Physiol. Genomics. 25 (1): 9–15. doi:10.1152/physiolgenomics.00121.2005. PMID 16368877.
Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19". Nature. 428 (6982): 529–35. Bibcode:2004Natur.428..529G. doi:10.1038/nature02399. PMID 15057824.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Liu HY; Meakin SO (2002). "ShcB and ShcC activation by the Trk family of receptor tyrosine kinases". J. Biol. Chem. 277 (29): 26046–56. doi:10.1074/jbc.M111659200. PMID 12006576.
Warner AJ, Lopez-Dee J, Knight EL, et al. (2001). "The Shc-related adaptor protein, Sck, forms a complex with the vascular-endothelial-growth-factor receptor KDR in transfected cells". Biochem. J. 347 (Pt 2): 501–9. doi:10.1042/0264-6021:3470501. PMC 1220983. PMID 10749680.
Pelicci G, Dente L, De Giuseppe A, et al. (1996). "A family of Shc related proteins with conserved PTB, CH1 and SH2 regions". Oncogene. 13 (3): 633–41. PMID 8760305.

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