SHC3

SHC3

Identifiers

SHC3, N-Shc, NSHC, RAI, SHCC, SHC adaptor protein 3

External IDs

OMIM: 605263; MGI: 106179; GeneCards: SHC3

Gene location (Human)

Chr.	Chromosome 9 (human)

Band	9q22.1	Start	89,005,771 bp
Band	9q22.1	End	89,178,818 bp

Gene location (Mouse)

Chr.	Chromosome 13 (mouse)

Band	13 A5\|13 26.12 cM	Start	51,585,077 bp
Band	13 A5\|13 26.12 cM	End	51,723,523 bp

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

Brodmann area 23

middle temporal gyrus

endothelial cell

superior frontal gyrus

postcentral gyrus

entorhinal cortex

primary visual cortex

orbitofrontal cortex

frontal pole

dorsolateral prefrontal cortex

Top expressed in

dentate gyrus of hippocampal formation granule cell

lumbar subsegment of spinal cord

superior frontal gyrus

superior surface of tongue

gallbladder

ventricular zone

primary visual cortex

secondary oocyte

zygote

morula

More reference expression data


More reference expression data

Gene ontology
Molecular function	receptor tyrosine kinase binding signal transducer activity protein binding phosphotyrosine residue binding
Cellular component	cytosol plasma membrane cellular component
Biological process	intracellular signal transduction epidermal growth factor receptor signaling pathway synaptic transmission, glutamatergic transmembrane receptor protein tyrosine kinase signaling pathway MAPK cascade central nervous system development learning or memory Ras protein signal transduction signal transduction axon guidance
Sources:Amigo / QuickGO

Databases

NCBI: entry; OMA: entry

Species

Human

Mouse


53358


20418


ENSG00000148082


ENSMUSG00000021448


Q92529


Q61120

RefSeq (mRNA)


NM_016848


NM_009167

RefSeq (protein)


NP_058544


NP_033193

Location (UCSC)

Chr 9: 89.01 – 89.18 Mb

Chr 13: 51.59 – 51.72 Mb

PubMed search

View/Edit Human

View/Edit Mouse

SHC-transforming protein 3 is a protein that in humans is encoded by the SHC3 gene.

Interactions

SHC3 has been shown to interact with RICS and TrkB.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000148082 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021448 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Nakamura T, Sanokawa R, Sasaki Y, Ayusawa D, Oishi M, Mori N (September 1996). "N-Shc: a neural-specific adapter molecule that mediates signaling from neurotrophin/Trk to Ras/MAPK pathway". Oncogene. 13 (6): 1111–21. PMID 8808684.
↑ "Entrez Gene: SHC3 SHC (Src homology 2 domain containing) transforming protein 3".
↑ Nakamura T, Komiya M, Sone K, Hirose E, Gotoh N, Morii H, Ohta Y, Mori N (December 2002). "Grit, a GTPase-activating protein for the Rho family, regulates neurite extension through association with the TrkA receptor and N-Shc and CrkL/Crk adapter molecules". Molecular and Cellular Biology. 22 (24): 8721–34. doi:10.1128/MCB.22.24.8721-8734.2002. PMC 139861. PMID 12446789.
↑ Nakamura T, Muraoka S, Sanokawa R, Mori N (March 1998). "N-Shc and Sck, two neuronally expressed Shc adapter homologs. Their differential regional expression in the brain and roles in neurotrophin and Src signaling". The Journal of Biological Chemistry. 273 (12): 6960–7. doi:10.1074/jbc.273.12.6960. PMID 9507002.
↑ Suzuki S, Mizutani M, Suzuki K, Yamada M, Kojima M, Hatanaka H, Koizumi S (June 2002). "Brain-derived neurotrophic factor promotes interaction of the Nck2 adaptor protein with the TrkB tyrosine kinase receptor". Biochemical and Biophysical Research Communications. 294 (5): 1087–92. doi:10.1016/S0006-291X(02)00606-X. PMID 12074588.

Further reading

O'Bryan JP, Songyang Z, Cantley L, Der CJ, Pawson T (April 1996). "A mammalian adaptor protein with conserved Src homology 2 and phosphotyrosine-binding domains is related to Shc and is specifically expressed in the brain". Proceedings of the National Academy of Sciences of the United States of America. 93 (7): 2729–34. Bibcode:1996PNAS...93.2729O. doi:10.1073/pnas.93.7.2729. PMC 39699. PMID 8610109.
Pelicci G, Dente L, De Giuseppe A, Verducci-Galletti B, Giuli S, Mele S, Vetriani C, Giorgio M, Pandolfi PP, Cesareni G, Pelicci PG (August 1996). "A family of Shc related proteins with conserved PTB, CH1 and SH2 regions". Oncogene. 13 (3): 633–41. PMID 8760305.
Menegon A, Leoni C, Benfenati F, Valtorta F (September 1997). "Tat protein from HIV-1 activates MAP kinase in granular neurons and glial cells from rat cerebellum". Biochemical and Biophysical Research Communications. 238 (3): 800–5. doi:10.1006/bbrc.1997.7393. PMID 9325171.
Wang JF, Ganju RK, Liu ZY, Avraham H, Avraham S, Groopman JE (November 1997). "Signal transduction in human hematopoietic cells by vascular endothelial growth factor related protein, a novel ligand for the FLT4 receptor". Blood. 90 (9): 3507–15. doi:10.1182/blood.V90.9.3507. PMID 9345034.
Nakamura T, Muraoka S, Sanokawa R, Mori N (March 1998). "N-Shc and Sck, two neuronally expressed Shc adapter homologs. Their differential regional expression in the brain and roles in neurotrophin and Src signaling". The Journal of Biological Chemistry. 273 (12): 6960–7. doi:10.1074/jbc.273.12.6960. PMID 9507002.
Cook KK, Fadool DA (April 2002). "Two adaptor proteins differentially modulate the phosphorylation and biophysics of Kv1.3 ion channel by SRC kinase". The Journal of Biological Chemistry. 277 (15): 13268–80. doi:10.1074/jbc.M108898200. PMC 2779217. PMID 11812778.
Tarr PE, Roncarati R, Pelicci G, Pelicci PG, D'Adamio L (May 2002). "Tyrosine phosphorylation of the beta-amyloid precursor protein cytoplasmic tail promotes interaction with Shc". The Journal of Biological Chemistry. 277 (19): 16798–804. doi:10.1074/jbc.M110286200. PMID 11877420.
Liu HY, Meakin SO (July 2002). "ShcB and ShcC activation by the Trk family of receptor tyrosine kinases". The Journal of Biological Chemistry. 277 (29): 26046–56. doi:10.1074/jbc.M111659200. PMID 12006576.
Miyake I, Hakomori Y, Shinohara A, Gamou T, Saito M, Iwamatsu A, Sakai R (August 2002). "Activation of anaplastic lymphoma kinase is responsible for hyperphosphorylation of ShcC in neuroblastoma cell lines". Oncogene. 21 (38): 5823–34. doi:10.1038/sj.onc.1205735. PMID 12185581. S2CID 27978633.
Pelicci G, Troglio F, Bodini A, Melillo RM, Pettirossi V, Coda L, De Giuseppe A, Santoro M, Pelicci PG (October 2002). "The neuron-specific Rai (ShcC) adaptor protein inhibits apoptosis by coupling Ret to the phosphatidylinositol 3-kinase/Akt signaling pathway". Molecular and Cellular Biology. 22 (20): 7351–63. doi:10.1128/MCB.22.20.7351-7363.2002. PMC 139827. PMID 12242309.
Nakamura T, Komiya M, Sone K, Hirose E, Gotoh N, Morii H, Ohta Y, Mori N (December 2002). "Grit, a GTPase-activating protein for the Rho family, regulates neurite extension through association with the TrkA receptor and N-Shc and CrkL/Crk adapter molecules". Molecular and Cellular Biology. 22 (24): 8721–34. doi:10.1128/MCB.22.24.8721-8734.2002. PMC 139861. PMID 12446789.
Miyake I, Hakomori Y, Misu Y, Nakadate H, Matsuura N, Sakamoto M, Sakai R (April 2005). "Domain-specific function of ShcC docking protein in neuroblastoma cells". Oncogene. 24 (19): 3206–15. doi:10.1038/sj.onc.1208523. PMID 15735675. S2CID 22484454.
Magrassi L, Conti L, Lanterna A, Zuccato C, Marchionni M, Cassini P, Arienta C, Cattaneo E (August 2005). "Shc3 affects human high-grade astrocytomas survival". Oncogene. 24 (33): 5198–206. doi:10.1038/sj.onc.1208708. hdl:11572/99142. PMID 15870690.
De Falco V, Guarino V, Malorni L, Cirafici AM, Troglio F, Erreni M, Pelicci G, Santoro M, Melillo RM (September 2005). "RAI(ShcC/N-Shc)-dependent recruitment of GAB 1 to RET oncoproteins potentiates PI 3-K signalling in thyroid tumors". Oncogene. 24 (41): 6303–13. doi:10.1038/sj.onc.1208776. PMID 15940252.
Toschi E, Bacigalupo I, Strippoli R, Chiozzini C, Cereseto A, Falchi M, Nappi F, Sgadari C, Barillari G, Mainiero F, Ensoli B (April 2006). "HIV-1 Tat regulates endothelial cell cycle progression via activation of the Ras/ERK MAPK signaling pathway". Molecular Biology of the Cell. 17 (4): 1985–94. doi:10.1091/mbc.E05-08-0717. PMC 1415297. PMID 16436505.
Li MD, Sun D, Lou XY, Beuten J, Payne TJ, Ma JZ (May 2007). "Linkage and association studies in African- and Caucasian-American populations demonstrate that SHC3 is a novel susceptibility locus for nicotine dependence". Molecular Psychiatry. 12 (5): 462–73. doi:10.1038/sj.mp.4001933. PMID 17179996. S2CID 11319299.

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