SIAH2

SIAH2
Identifiers
Aliases	SIAH2, hSiah2, siah E3 ubiquitin protein ligase 2
External IDs	OMIM: 602213; MGI: 108062; GeneCards: SIAH2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	5H9M
Enzyme activity
Gene location (Human)
Chr.	Chromosome 3 (human)
End	150,763,477 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	58,599,821 bp
RNA expression pattern
	Top expressed in
	right adrenal cortex; ; left adrenal gland; ; left adrenal cortex; ; monocyte; ; ectocervix; ; right lobe of liver; ; blood; ; canal of the cervix; ; bone marrow; ; stromal cell of endometrium;
	Top expressed in
	secondary oocyte; ; zygote; ; primary oocyte; ; seminiferous tubule; ; spermatid; ; olfactory epithelium; ; ankle joint; ; parotid gland; ; right kidney; ; islet of Langerhans;
	More reference expression data
	n/a
Gene ontology
Molecular function	transcription corepressor activity; zinc ion binding; metal ion binding; protein binding; ubiquitin conjugating enzyme binding; transferase activity; ubiquitin-protein transferase activity; ubiquitin protein ligase activity;
Cellular component	cytoplasm; cytosol; intracellular membrane-bounded organelle; nucleoplasm; soma; early endosome; neuron projection; nucleus;
Biological process	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; small GTPase mediated signal transduction; regulation of protein ubiquitination; negative regulation of extrinsic apoptotic signaling pathway; negative regulation of apoptotic process; axon guidance; multicellular organism development; protein ubiquitination; cell cycle; negative regulation of canonical Wnt signaling pathway; apoptotic process; negative regulation of nucleic acid-templated transcription; protein polyubiquitination; protein deubiquitination; ubiquitin-dependent protein catabolic process; negative regulation of netrin-activated signaling pathway; proteasome-mediated ubiquitin-dependent protein catabolic process; regulation of circadian rhythm; rhythmic process;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	6478
	20439
	ENSG00000181788
	ENSMUSG00000036432
	O43255
	Q06986
	NM_005067
	NM_009174
	NP_005058
	NP_033200
	Wikidata
View/Edit Human	View/Edit Mouse

E3 ubiquitin-protein ligase SIAH2 is an enzyme that in humans is encoded by the SIAH2 gene.

Function

This gene encodes a protein that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in regulating cellular response to hypoxia.

Interactions

SIAH2 has been shown to interact with PEG10, Synaptophysin, PEG3 and VAV1.