Sialic acid binding Ig-like lectin 15

SIGLEC15
Identifiers
Aliases	SIGLEC15, CD33L3, HsT1361, SIGLEC-15, Sialic acid binding ig-like lectin 15, sialic acid binding Ig like lectin 15
External IDs	OMIM: 618105; MGI: 3646642; GeneCards: SIGLEC15
Gene location (Human)
Chr.	Chromosome 18 (human)
End	45,844,094 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	78,100,610 bp
RNA expression pattern
	Top expressed in
	jejunal mucosa; ; buccal mucosa cell; ; periodontal fiber; ; pancreatic ductal cell; ; tibia; ; duodenum; ; amniotic fluid; ; mononuclear cell; ; monocyte; ; lactiferous duct;
	Top expressed in
	embryo; ; embryo; ; ovary; ; urinary bladder; ; thymus;
	More reference expression data
	n/a
Orthologs
Databases	NCBI: entry; OMA: entry
	284266
	620235
	ENSG00000197046
	ENSMUSG00000091055
	Q6ZMC9
	A7E1W8
	NM_213602
	NM_001101038
	NP_998767
	NP_001094508
	Wikidata
View/Edit Human	View/Edit Mouse

Sialic acid binding Ig-like lectin 15 (Siglec-15) is a protein that in humans is encoded by the SIGLEC15 gene. Siglec-15 is predominately expressed on osteoclasts, elevated levels of Siglec- 15 in the bone metastatic niche can promote tumor-induced osteoclastogenesis as well as suppress antigen-specific T cell responses. Researchers demonstrated that antibody blockade of the Siglec-15/sialic acid glycol-immune checkpoint axis can act as a potential treatment for breast cancer bone metastasis.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000197046 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000091055 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: Sialic acid binding Ig-like lectin 15".
↑ Wang Y, Zhan X, et al. (January 22, 2024). "Siglec-15/sialic acid axis as a central glyco-immune checkpoint in breast cancer bone metastasis". Proceedings of the National Academy of Sciences of the United States of America. 121 (5) e2312929121. doi:10.1073/pnas.2312929121. PMC 10835054. PMID 38252825.

Wang Y, Zhan X, et al. (January 22, 2024). "Siglec-15/sialic acid axis as a central glyco-immune checkpoint in breast cancer bone metastasis". Proceedings of the National Academy of Sciences of the United States of America. 121 (5) e2312929121. doi:10.1073/pnas.2312929121. PMC 10835054. PMID 38252825.
Takamiya R, Ohtsubo K, Takamatsu S, Taniguchi N, Angata T (February 2013). "The interaction between Siglec-15 and tumor-associated sialyl-Tn antigen enhances TGF-β secretion from monocytes/macrophages through the DAP12-Syk pathway". Glycobiology. 23 (2): 178–87. doi:10.1093/glycob/cws139. PMID 23035012.
Angata T, Tabuchi Y, Nakamura K, Nakamura M (August 2007). "Siglec-15: an immune system Siglec conserved throughout vertebrate evolution". Glycobiology. 17 (8): 838–46. doi:10.1093/glycob/cwm049. PMID 17483134.

This article on a gene on human chromosome 18 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000197046 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000091055 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Sialic acid binding Ig-like lectin 15".

[siglec15-6] Wang Y, Zhan X, et al. (January 22, 2024). "Siglec-15/sialic acid axis as a central glyco-immune checkpoint in breast cancer bone metastasis". Proceedings of the National Academy of Sciences of the United States of America. 121 (5) e2312929121. doi:10.1073/pnas.2312929121. PMC 10835054. PMID 38252825.

Sialic acid binding Ig-like lectin 15

References

Further reading