SIPA1L1

SIPA1L1

Identifiers

SIPA1L1, E6TP1, signal induced proliferation associated 1 like 1, SPAR1

External IDs

OMIM: 617504; MGI: 2443679; GeneCards: SIPA1L1

Gene location (Human)

Chr.	Chromosome 14 (human)

Band	14q24.2	Start	71,320,449 bp
Band	14q24.2	End	71,741,229 bp

Gene location (Mouse)

Chr.	Chromosome 12 (mouse)

Band	12\|12 D1	Start	82,216,094 bp
Band	12\|12 D1	End	82,498,560 bp

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

nucleus accumbens

testicle

external globus pallidus

caudate nucleus

Region I of hippocampus proper

right frontal lobe

right hemisphere of cerebellum

sural nerve

popliteal artery

tibial arteries

Top expressed in

olfactory tubercle

temporal lobe

nucleus accumbens

primary motor cortex

prefrontal cortex

amygdala

lateral septal nucleus

Region I of hippocampus proper

piriform cortex

vestibular membrane of cochlear duct

More reference expression data


More reference expression data

Gene ontology
Molecular function	GTPase activator activity ephrin receptor binding molecular function
Cellular component	cytoplasm postsynaptic membrane membrane postsynaptic density plasma membrane dendritic spine synapse cell junction neuron projection cytoskeleton cellular component
Biological process	actin cytoskeleton reorganization activation of GTPase activity regulation of GTPase activity ephrin receptor signaling pathway regulation of synaptic plasticity regulation of dendrite morphogenesis regulation of axonogenesis regulation of small GTPase mediated signal transduction regulation of dendritic spine morphogenesis biological process
Sources:Amigo / QuickGO

Databases

NCBI: entry; OMA: entry

Species

Human

Mouse


26037


217692


ENSG00000197555


ENSMUSG00000042700


O43166


Q8C0T5

RefSeq (mRNA)

NM_001284245 NM_001284246 NM_001284247 NM_015556 NM_001354285
NM_001354286 NM_001354287 NM_001354288 NM_001354289 NM_001386936


NM_001167983 NM_172579

RefSeq (protein)

NP_001271174 NP_001271175 NP_001271176 NP_056371 NP_001341214
NP_001341215 NP_001341216 NP_001341217 NP_001341218

NP_001161455 NP_766167 NP_001394331 NP_001394332 NP_001394333
NP_001394334 NP_001394335 NP_001394336 NP_001394337 NP_001394338 NP_001394339 NP_001394340 NP_001394341 NP_001394342 NP_001394343 NP_001394344

Location (UCSC)

Chr 14: 71.32 – 71.74 Mb

Chr 12: 82.22 – 82.5 Mb

PubMed search

View/Edit Human

View/Edit Mouse

Signal-induced proliferation-associated 1-like protein 1 is a protein that in humans is encoded by the SIPA1L1 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000197555 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000042700 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Gao Q, Srinivasan S, Boyer SN, Wazer DE, Band V (January 1999). "The E6 oncoproteins of high-risk papillomaviruses bind to a novel putative GAP protein, E6TP1, and target it for degradation". Molecular and Cellular Biology. 19 (1): 733–44. doi:10.1128/mcb.19.1.733. PMC 83930. PMID 9858596.
↑ "Entrez Gene: SIPA1L1 signal-induced proliferation-associated 1 like 1".

Further reading

Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T (June 2002). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Research. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Lee C, Wooldridge TR, Laimins LA (February 2007). "Analysis of the roles of E6 binding to E6TP1 and nuclear localization in the human papillomavirus type 31 life cycle". Virology. 358 (1): 201–10. doi:10.1016/j.virol.2006.08.028. PMID 16999984.
Benzinger A, Muster N, Koch HB, Yates JR, Hermeking H (June 2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer". Molecular & Cellular Proteomics. 4 (6): 785–95. doi:10.1074/mcp.M500021-MCP200. PMID 15778465.
Chih DY, Park DJ, Gross M, Idos G, Vuong PT, Hirama T, Chumakov AM, Said J, Koeffler HP (December 2004). "Protein partners of C/EBPepsilon". Experimental Hematology. 32 (12): 1173–81. doi:10.1016/j.exphem.2004.08.014. PMID 15588942.
Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (August 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Nakayama M, Kikuno R, Ohara O (November 2002). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs". Genome Research. 12 (11): 1773–84. doi:10.1101/gr.406902. PMC 187542. PMID 12421765.
Pak DT, Yang S, Rudolph-Correia S, Kim E, Sheng M (August 2001). "Regulation of dendritic spine morphology by SPAR, a PSD-95-associated RapGAP". Neuron. 31 (2): 289–303. doi:10.1016/S0896-6273(01)00355-5. PMID 11502259.
Ishikawa K, Nagase T, Nakajima D, Seki N, Ohira M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (October 1997). "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 4 (5): 307–13. doi:10.1093/dnares/4.5.307. PMID 9455477.

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