SLC25A51

SLC25A51
Identifiers
Aliases	SLC25A51, CG7943, MCART1, solute carrier family 25 member 51
External IDs	MGI: 2684984; GeneCards: SLC25A51
Gene location (Human)
Chr.	Chromosome 9 (human)
End	37,904,353 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	45,408,766 bp
RNA expression pattern
	Top expressed in
	gonad; ; islet of Langerhans; ; stromal cell of endometrium; ; bone marrow cell; ; secondary oocyte; ; gastrocnemius muscle; ; right ventricle; ; monocyte; ; ganglionic eminence; ; epithelium of colon;
	Top expressed in
	fetal liver hematopoietic progenitor cell; ; Rostral migratory stream; ; brown adipose tissue; ; blood; ; knee joint; ; vastus lateralis muscle; ; motor neuron; ; intercostal muscle; ; right kidney; ; muscle of thigh;
	More reference expression data
	n/a
Gene ontology
Molecular function	transmembrane transporter activity;
Cellular component	membrane; mitochondrion; mitochondrial inner membrane; integral component of membrane;
Biological process	mitochondrial transport; transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	92014
	230125
	ENSG00000122696
	ENSMUSG00000045973
	Q9H1U9
	Q5HZI9
	NM_033412
	NM_001009949
	NP_219480
	NP_001009949
	Wikidata
View/Edit Human	View/Edit Mouse

Solute carrier family 25 member 51, also known as SLC25A51 and MCART1, is a protein which in humans is encoded by the SLC25A51 gene. This gene encodes a mitochondrial NAD⁺ transporter and is a member of the mitochondrial carrier family of solute carrier proteins.

Structure

The SLC25A51 gene is located on the p arm of chromosome 9 in position 13.2 and spans 24,954 base pairs. The gene produces a 33.7 kDa protein composed of 297 amino acids. This gene has 6 exons and encodes a multi-pass integral membrane protein localized to the mitochondrial inner membrane.

Function

The product of this gene (MCART1) is essential for the import of NAD⁺ into the mitochondria.

Clinical significance

Diseases associated with this gene include urea cycle disorders.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000122696 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000045973 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 Girardi, Enrico; Agrimi, Gennaro; Goldmann, Ulrich; Fiume, Giuseppe; Lindinger, Sabrina; Sedlyarov, Vitaly; Srndic, Ismet; Gürtl, Bettina; Agerer, Benedikt; Kartnig, Felix; Scarcia, Pasquale; Di Noia, Maria Antonietta; Liñeiro, Eva; Rebsamen, Manuele; Wiedmer, Tabea (2020-12-01). "Epistasis-driven identification of SLC25A51 as a regulator of human mitochondrial NAD import". Nature Communications. 11 (1): 6145. Bibcode:2020NatCo..11.6145G. doi:10.1038/s41467-020-19871-x. ISSN 2041-1723. PMC 7708531. PMID 33262325.
1 2 "SLC25A51 solute carrier family 25 member 51 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2025-09-09.
1 2 "UniProt". UniProt. Retrieved 2025-09-09.
↑ Kory, Nora; uit de Bos, Jelmi; van der Rijt, Sanne; Jankovic, Nevena; Güra, Miriam; Arp, Nicholas; Pena, Izabella A.; Prakash, Gyan; Chan, Sze Ham; Kunchok, Tenzin; Lewis, Caroline A.; Sabatini, David M. (2020-10-21). "MCART1/SLC25A51 is required for mitochondrial NAD transport". Science Advances. 6 (43) eabe5310. Bibcode:2020SciA....6.5310K. doi:10.1126/sciadv.abe5310. PMC 7577609. PMID 33087354.
↑ Luongo, Timothy S.; Eller, Jared M.; Lu, Mu-Jie; Niere, Marc; Raith, Fabio; Perry, Caroline; Bornstein, Marc R.; Oliphint, Paul; Wang, Lin; McReynolds, Melanie R.; Migaud, Marie E.; Rabinowitz, Joshua D.; Johnson, F. Brad; Johnsson, Kai; Ziegler, Mathias (December 2020). "SLC25A51 is a mammalian mitochondrial NAD+ transporter". Nature. 588 (7836): 174–179. doi:10.1038/s41586-020-2741-7. ISSN 1476-4687. PMC 7718333. PMID 32906142.
↑ "DISEASES - SLC25A51". diseases.jensenlab.org. Retrieved 2025-09-09.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000122696 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000045973 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[:0-5] 1 2 Girardi, Enrico; Agrimi, Gennaro; Goldmann, Ulrich; Fiume, Giuseppe; Lindinger, Sabrina; Sedlyarov, Vitaly; Srndic, Ismet; Gürtl, Bettina; Agerer, Benedikt; Kartnig, Felix; Scarcia, Pasquale; Di Noia, Maria Antonietta; Liñeiro, Eva; Rebsamen, Manuele; Wiedmer, Tabea (2020-12-01). "Epistasis-driven identification of SLC25A51 as a regulator of human mitochondrial NAD import". Nature Communications. 11 (1): 6145. Bibcode:2020NatCo..11.6145G. doi:10.1038/s41467-020-19871-x. ISSN 2041-1723. PMC 7708531. PMID 33262325.

[:1-6] 1 2 "SLC25A51 solute carrier family 25 member 51 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2025-09-09.

[:2-7] 1 2 "UniProt". UniProt. Retrieved 2025-09-09.

[8] Kory, Nora; uit de Bos, Jelmi; van der Rijt, Sanne; Jankovic, Nevena; Güra, Miriam; Arp, Nicholas; Pena, Izabella A.; Prakash, Gyan; Chan, Sze Ham; Kunchok, Tenzin; Lewis, Caroline A.; Sabatini, David M. (2020-10-21). "MCART1/SLC25A51 is required for mitochondrial NAD transport". Science Advances. 6 (43) eabe5310. Bibcode:2020SciA....6.5310K. doi:10.1126/sciadv.abe5310. PMC 7577609. PMID 33087354.

[9] Luongo, Timothy S.; Eller, Jared M.; Lu, Mu-Jie; Niere, Marc; Raith, Fabio; Perry, Caroline; Bornstein, Marc R.; Oliphint, Paul; Wang, Lin; McReynolds, Melanie R.; Migaud, Marie E.; Rabinowitz, Joshua D.; Johnson, F. Brad; Johnsson, Kai; Ziegler, Mathias (December 2020). "SLC25A51 is a mammalian mitochondrial NAD+ transporter". Nature. 588 (7836): 174–179. doi:10.1038/s41586-020-2741-7. ISSN 1476-4687. PMC 7718333. PMID 32906142.

[10] "DISEASES - SLC25A51". diseases.jensenlab.org. Retrieved 2025-09-09.

SLC25A51

Structure

Function

Clinical significance

See also

References