SLC48A1

SLC48A1
Identifiers
Aliases	SLC48A1, HRG-1, HRG1, hHRG-1, solute carrier family 48 member 1
External IDs	OMIM: 612187; MGI: 1914989; GeneCards: SLC48A1
Gene location (Human)
Chr.	Chromosome 12 (human)
End	47,782,751 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	97,690,573 bp
RNA expression pattern
	Top expressed in
	C1 segment; ; inferior ganglion of vagus nerve; ; putamen; ; substantia nigra; ; subthalamic nucleus; ; amygdala; ; caudate nucleus; ; right frontal lobe; ; right lobe of thyroid gland; ; ventral tegmental area;
	Top expressed in
	blood; ; right kidney; ; stroma of bone marrow; ; superior frontal gyrus; ; retinal pigment epithelium; ; proximal tubule; ; calvaria; ; lip; ; dentate gyrus of hippocampal formation granule cell; ; tibiofemoral joint;
	More reference expression data
	n/a
Gene ontology
Molecular function	heme transmembrane transporter activity; heme binding; protein binding;
Cellular component	integral component of membrane; endosome; lysosome; membrane; lysosomal membrane; plasma membrane; endosome membrane;
Biological process	heme transport;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	55652
	67739
	ENSG00000211584
	ENSMUSG00000081534
	Q6P1K1
	Q9D8M3
	NM_017842
	NM_026353
	NP_060312
	NP_080629
	Wikidata
View/Edit Human	View/Edit Mouse

SLC48A1 is a protein that in humans is encoded by the SLC48A1 gene. SLC48A1 encodes the protein known as heme transporter HRG1, which acts as a solute carrier for transmembrane transport of heme.

SLC48A1 belongs to solute carrier family 48, and the HRG family, where it is found along with other membrane transporters involved in heme handling.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000211584 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000081534 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 "SLC48A1 Gene - GeneCards". www.genecards.org. Retrieved 2026-10-03.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000211584 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000081534 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[:1-5] 1 2 "SLC48A1 Gene - GeneCards". www.genecards.org. Retrieved 2026-10-03.