Sodium- and chloride-dependent taurine transporter

SLC6A6

Identifiers

SLC6A6, TAUT, solute carrier family 6 member 6, HTRDC

External IDs

OMIM: 186854; MGI: 98488; GeneCards: SLC6A6

Gene location (Human)

Chr.	Chromosome 3 (human)

Band	3p25.1	Start	14,402,576 bp
Band	3p25.1	End	14,489,349 bp

Gene location (Mouse)

Chr.	Chromosome 6 (mouse)

Band	6 D1\|6 40.73 cM	Start	91,684,053 bp
Band	6 D1\|6 40.73 cM	End	91,759,066 bp

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

mucosa of paranasal sinus

palpebral conjunctiva

olfactory zone of nasal mucosa

blood

visceral pleura

bronchial epithelial cell

epithelium of nasopharynx

monocyte

skin of hip

germinal epithelium

Top expressed in

ciliary body

neural layer of retina

iris

skin of external ear

calvaria

retinal pigment epithelium

ankle joint

gastrula

decidua

stroma of bone marrow

More reference expression data


More reference expression data

Gene ontology
Molecular function	neurotransmitter:sodium symporter activity symporter activity amino acid transmembrane transporter activity taurine:sodium symporter activity
Cellular component	integral component of membrane plasma membrane integral component of plasma membrane membrane
Biological process	cellular amino acid metabolic process amino acid transmembrane transport neurotransmitter transport amino acid transport taurine transport transmembrane transport
Sources:Amigo / QuickGO

Databases

NCBI: entry; OMA: entry

Species

Human

Mouse


6533


21366


ENSG00000131389


ENSMUSG00000030096


P31641


O35316

RefSeq (mRNA)


NM_001134367 NM_001134368 NM_003043


NM_009320

RefSeq (protein)


NP_001127839 NP_001127840 NP_003034


NP_033346

Location (UCSC)

Chr 3: 14.4 – 14.49 Mb

Chr 6: 91.68 – 91.76 Mb

PubMed search

View/Edit Human

View/Edit Mouse

Sodium- and chloride-dependent taurine transporter is a protein that in humans is encoded by the SLC6A6 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000131389 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000030096 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Ramamoorthy S, Leibach FH, Mahesh VB, Han H, Yang-Feng T, Blakely RD, Ganapathy V (Jul 1994). "Functional characterization and chromosomal localization of a cloned taurine transporter from human placenta". Biochem J. 300 (3): 893–900. doi:10.1042/bj3000893. PMC 1138249. PMID 8010975.
↑ Jhiang SM, Fithian L, Smanik P, McGill J, Tong Q, Mazzaferri EL (Mar 1993). "Cloning of the human taurine transporter and characterization of taurine uptake in thyroid cells". FEBS Lett. 318 (2): 139–44. doi:10.1016/0014-5793(93)80008-I. PMID 8382624. S2CID 28368668.
↑ "Entrez Gene: SLC6A6 solute carrier family 6 (neurotransmitter transporter, taurine), member 6".

Further reading

Uchida S, Kwon HM, Yamauchi A, et al. (1992). "Molecular cloning of the cDNA for an MDCK cell Na(+)- and Cl(−)-dependent taurine transporter that is regulated by hypertonicity". Proc. Natl. Acad. Sci. U.S.A. 89 (17): 8230–4. Bibcode:1992PNAS...89.8230U. doi:10.1073/pnas.89.17.8230. PMC 49891. PMID 1518851.
Miyamoto Y, Liou GI, Sprinkle TJ (1996). "Isolation of a cDNA encoding a taurine transporter in the human retinal pigment epithelium". Curr. Eye Res. 15 (3): 345–9. doi:10.3109/02713689609007631. PMID 8654117.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Mochizuki T, Satsu H, Shimizu M (2002). "Tumor necrosis factor alpha stimulates taurine uptake and transporter gene expression in human intestinal Caco-2 cells". FEBS Lett. 517 (1–3): 92–6. doi:10.1016/S0014-5793(02)02584-X. PMID 12062416. S2CID 86171679.
Han X, Patters AB, Chesney RW (2002). "Transcriptional repression of taurine transporter gene (TauT) by p53 in renal cells". J. Biol. Chem. 277 (42): 39266–73. doi:10.1074/jbc.M205939200. PMID 12163498.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Han X, Chesney RW (2003). "Regulation of taurine transporter gene (TauT) by WT1". FEBS Lett. 540 (1–3): 71–6. doi:10.1016/S0014-5793(03)00227-8. PMID 12681485. S2CID 32139788.
Roos S, Powell TL, Jansson T (2004). "Human placental taurine transporter in uncomplicated and IUGR pregnancies: cellular localization, protein expression, and regulation". Am. J. Physiol. Regul. Integr. Comp. Physiol. 287 (4): R886–93. CiteSeerX 10.1.1.1026.3853. doi:10.1152/ajpregu.00232.2004. PMID 15166008. {{cite journal}}: Cite uses deprecated parameter |citeseerx= (help)
Satsu H, Manabe M, Shimizu M (2004). "Activation of Ca2+/calmodulin-dependent protein kinase II is involved in hyperosmotic induction of the human taurine transporter". FEBS Lett. 569 (1–3): 123–8. doi:10.1016/j.febslet.2004.05.062. PMID 15225620. S2CID 11395494.
Mochizuki T, Satsu H, Nakano T, Shimizu M (2005). "Regulation of the human taurine transporter by TNF-alpha and an anti-inflammatory function of taurine in human intestinal Caco-2 cells". BioFactors. 21 (1–4): 141–4. doi:10.1002/biof.552210128. PMID 15630186. S2CID 35504141.
Mochizuki T, Satsu H, Shimizu M (2005). "Signaling pathways involved in tumor necrosis factor alpha-induced upregulation of the taurine transporter in Caco-2 cells". FEBS Lett. 579 (14): 3069–74. doi:10.1016/j.febslet.2005.04.063. PMID 15907840. S2CID 84235462.
Nakashima E, Pop-Busui R, Towns R, et al. (2006). "Regulation of the human taurine transporter by oxidative stress in retinal pigment epithelial cells stably transformed to overexpress aldose reductase" (PDF). Antioxid. Redox Signal. 7 (11–12): 1530–42. doi:10.1089/ars.2005.7.1530. hdl:2027.42/63284. PMID 16356117.
Iruloh CG, D'Souza SW, Speake PF, et al. (2007). "Taurine transporter in fetal T lymphocytes and platelets: differential expression and functional activity". Am. J. Physiol., Cell Physiol. 292 (1): C332–41. doi:10.1152/ajpcell.00634.2005. PMID 16956961.

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