SLIT1

SLIT1
Identifiers
Aliases	SLIT1, MEGF4, SLIL1, SLIT-1, SLIT3, slit guidance ligand 1
External IDs	OMIM: 603742; MGI: 1315203; GeneCards: SLIT1
Gene location (Human)
Chr.	Chromosome 10 (human)
End	97,185,959 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	41,732,104 bp
RNA expression pattern
	Top expressed in
	middle temporal gyrus; ; orbitofrontal cortex; ; Region I of hippocampus proper; ; Brodmann area 10; ; Brodmann area 23; ; Brodmann area 46; ; entorhinal cortex; ; superior frontal gyrus; ; pancreatic ductal cell; ; frontal pole;
	Top expressed in
	dentate gyrus of hippocampal formation granule cell; ; primary visual cortex; ; superior frontal gyrus; ; urethra; ; male urethra; ; hippocampus proper; ; stellate reticulum; ; enamel knot; ; ventricular zone; ; Rostral migratory stream;
	More reference expression data
	n/a
Gene ontology
Molecular function	calcium ion binding; Roundabout binding; heparin binding;
Cellular component	extracellular region; extracellular space; intracellular anatomical structure;
Biological process	chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration; cell differentiation; neuron projection morphogenesis; dorsal/ventral axon guidance; negative chemotaxis; axonogenesis; negative regulation of synapse assembly; nervous system development; telencephalon cell migration; multicellular organism development; forebrain morphogenesis; tangential migration from the subventricular zone to the olfactory bulb; olfactory bulb development; motor neuron axon guidance; axon extension involved in axon guidance; retinal ganglion cell axon guidance; axon guidance; nuclear migration;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	6585
	20562
	ENSG00000187122
	ENSMUSG00000025020
	O75093
	Q80TR4
	NM_003061
	NM_015748
	NP_003052
	NP_056563
	Wikidata
View/Edit Human	View/Edit Mouse

Slit homolog 1 protein is a protein that in humans is encoded by the SLIT1 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000187122 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025020 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Nakayama M, Nakajima D, Nagase T, Nomura N, Seki N, Ohara O (July 1998). "Identification of high-molecular-weight proteins with multiple EGF-like motifs by motif-trap screening". Genomics. 51 (1): 27–34. doi:10.1006/geno.1998.5341. PMID 9693030.
↑ Itoh A, Miyabayashi T, Ohno M, Sakano S (November 1998). "Cloning and expressions of three mammalian homologues of Drosophila slit suggest possible roles for Slit in the formation and maintenance of the nervous system". Brain Research. Molecular Brain Research. 62 (2): 175–86. doi:10.1016/S0169-328X(98)00224-1. PMID 9813312.
↑ "Entrez Gene: SLIT1 slit homolog 1 (Drosophila)".

Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T (June 2002). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Research. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
Wong K, Park HT, Wu JY, Rao Y (October 2002). "Slit proteins: molecular guidance cues for cells ranging from neurons to leukocytes". Current Opinion in Genetics & Development. 12 (5): 583–91. doi:10.1016/S0959-437X(02)00343-X. PMID 12200164.
Liang Y, Annan RS, Carr SA, Popp S, Mevissen M, Margolis RK, Margolis RU (June 1999). "Mammalian homologues of the Drosophila slit protein are ligands of the heparan sulfate proteoglycan glypican-1 in brain". The Journal of Biological Chemistry. 274 (25): 17885–92. doi:10.1074/jbc.274.25.17885. PMID 10364234.
Wu W, Wong K, Chen J, Jiang Z, Dupuis S, Wu JY, Rao Y (July 1999). "Directional guidance of neuronal migration in the olfactory system by the protein Slit". Nature. 400 (6742): 331–6. Bibcode:1999Natur.400..331W. doi:10.1038/22477. PMC 2041931. PMID 10432110.
Yuan W, Zhou L, Chen JH, Wu JY, Rao Y, Ornitz DM (August 1999). "The mouse SLIT family: secreted ligands for ROBO expressed in patterns that suggest a role in morphogenesis and axon guidance". Developmental Biology. 212 (2): 290–306. doi:10.1006/dbio.1999.9371. PMID 10433822.
Little M, Rumballe B, Georgas K, Yamada T, Teasdale RD (2003). "Conserved modularity and potential for alternate splicing in mouse and human Slit genes". The International Journal of Developmental Biology. 46 (4): 385–91. PMID 12141424.
Hammond R, Vivancos V, Naeem A, Chilton J, Mambetisaeva E, Mambitisaeva E, Andrews W, Sundaresan V, Guthrie S (October 2005). "Slit-mediated repulsion is a key regulator of motor axon pathfinding in the hindbrain" (PDF). Development. 132 (20): 4483–95. doi:10.1242/dev.02038. PMID 16162649. S2CID 25081153.
Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY (May 2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.
Lin L, Isacson O (November 2006). "Axonal growth regulation of fetal and embryonic stem cell-derived dopaminergic neurons by Netrin-1 and Slits". Stem Cells. 24 (11): 2504–13. doi:10.1634/stemcells.2006-0119. PMC 2613222. PMID 16840550.
Hussain SA, Piper M, Fukuhara N, Strochlic L, Cho G, Howitt JA, Ahmed Y, Powell AK, Turnbull JE, Holt CE, Hohenester E (December 2006). "A molecular mechanism for the heparan sulfate dependence of slit-robo signaling". The Journal of Biological Chemistry. 281 (51): 39693–8. doi:10.1074/jbc.M609384200. PMC 3680705. PMID 17062560.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000187122 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025020 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9693030-5] Nakayama M, Nakajima D, Nagase T, Nomura N, Seki N, Ohara O (July 1998). "Identification of high-molecular-weight proteins with multiple EGF-like motifs by motif-trap screening". Genomics. 51 (1): 27–34. doi:10.1006/geno.1998.5341. PMID 9693030.

[pmid9813312-6] Itoh A, Miyabayashi T, Ohno M, Sakano S (November 1998). "Cloning and expressions of three mammalian homologues of Drosophila slit suggest possible roles for Slit in the formation and maintenance of the nervous system". Brain Research. Molecular Brain Research. 62 (2): 175–86. doi:10.1016/S0169-328X(98)00224-1. PMID 9813312.

[entrez-7] "Entrez Gene: SLIT1 slit homolog 1 (Drosophila)".

SLIT1

References

Further reading