Structure-specific endonuclease subunit SLX1B
Structure-specific endonuclease subunit SLX1B is a protein in humans that is encoded by the SLX1B gene. The nearby gene, SLX1A, encodes an identical protein, and the protein is sometimes called structure-specific endonuclease subunit SLX1 when not specifying the origin gene.
This gene encodes a protein that is an important regulator of genome stability. The protein represents the catalytic subunit of the SLX1-SLX4 structure-specific endonuclease, which can resolve DNA secondary structures that are formed during repair and recombination processes. Two identical copies of this gene are located on the p arm of chromosome 16 due to a segmental duplication; this record represents the more telomeric copy. Alternative splicing results in multiple transcript variants. Read-through transcription also occurs between this gene and the downstream SULT1A4 (sulfotransferase family, cytosolic, 1A, phenol-preferring, member 4) gene. [provided by RefSeq, Nov 2010].
References
- 1 2 3 GRCh38: Ensembl release 89: ENSG00000181625 – Ensembl, May 2017
- 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000059772 – Ensembl, May 2017
- ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- 1 2 "Entrez Gene: SLX1 structure-specific endonuclease subunit homolog B (S. cerevisiae)". Retrieved 2013-05-19.
- ↑ "Structure-specific endonuclease subunit SLX1". UniProt consortium. Retrieved 2026-10-10.
Further reading
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