SMPD4

SMPD4
Identifiers
Aliases	SMPD4, NET13, NSMASE-3, NSMASE3, sphingomyelin phosphodiesterase 4, SKNY, NEDMABA, NEDMEBA
External IDs	OMIM: 610457; MGI: 1924876; GeneCards: SMPD4
Enzyme activity
Gene location (Human)
Chr.	Chromosome 2 (human)
End	130,182,750 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	17,462,692 bp
RNA expression pattern
	Top expressed in
	pituitary gland; ; anterior pituitary; ; right hemisphere of cerebellum; ; left lobe of thyroid gland; ; canal of the cervix; ; right lobe of thyroid gland; ; apex of heart; ; body of uterus; ; right uterine tube; ; left ovary;
	Top expressed in
	tail of embryo; ; otic vesicle; ; genital tubercle; ; otic placode; ; saccule; ; epiblast; ; spermatocyte; ; primary visual cortex; ; superior frontal gyrus; ; ventricular zone;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	sphingomyelin phosphodiesterase activity; hydrolase activity; metal ion binding; sphingomyelin phosphodiesterase D activity;
Cellular component	integral component of membrane; Golgi membrane; trans-Golgi network; Golgi apparatus; endoplasmic reticulum membrane; endoplasmic reticulum; membrane;
Biological process	ceramide biosynthetic process; cellular response to tumor necrosis factor; sphingomyelin catabolic process; glycosphingolipid metabolic process; glycerophospholipid catabolic process; metabolism;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	55627
	77626
	ENSG00000136699
	ENSMUSG00000005899
	Q9NXE4
	Q6ZPR5
	NM_001171083; NM_001171084; NM_017751; NM_017951
	NM_001164609; NM_001164610; NM_001164611; NM_029945
	NP_001164554; NP_060221; NP_060421; NP_060421.2
	NP_001158081; NP_001158082; NP_001158083; NP_084221
	Wikidata
View/Edit Human	View/Edit Mouse

Sphingomyelin phosphodiesterase 4 is an enzyme that in humans is encoded by the SMPD4 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000136699 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000005899 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Krut O, Wiegmann K, Kashkar H, Yazdanpanah B, Krönke M (May 2006). "Novel tumor necrosis factor-responsive mammalian neutral sphingomyelinase-3 is a C-tail-anchored protein". The Journal of Biological Chemistry. 281 (19): 13784–93. doi:10.1074/jbc.M511306200. PMID 16517606.
↑ "Entrez Gene: SMPD4 sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3)".

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Lehner B, Sanderson CM (Jul 2004). "A protein interaction framework for human mRNA degradation". Genome Research. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
Jana A, Pahan K (Oct 2004). "Human immunodeficiency virus type 1 gp120 induces apoptosis in human primary neurons through redox-regulated activation of neutral sphingomyelinase". The Journal of Neuroscience. 24 (43): 9531–40. doi:10.1523/JNEUROSCI.3085-04.2004. PMC 1955476. PMID 15509740.
Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (Jan 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000136699 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000005899 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid16517606-5] Krut O, Wiegmann K, Kashkar H, Yazdanpanah B, Krönke M (May 2006). "Novel tumor necrosis factor-responsive mammalian neutral sphingomyelinase-3 is a C-tail-anchored protein". The Journal of Biological Chemistry. 281 (19): 13784–93. doi:10.1074/jbc.M511306200. PMID 16517606.

[entrez-6] "Entrez Gene: SMPD4 sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3)".

SMPD4

References

Further reading