SMS (gene)

SMS
Identifiers
Aliases	SMS, MRSR, SPMSY, SRS, SpS, spermine synthase, MRXSSR
External IDs	OMIM: 300105; MGI: 3705601; GeneCards: SMS
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3C6K, 3C6M
Enzyme activity
Gene location (Human)
Chr.	X chromosome (human)
End	21,994,837 bp
RNA expression pattern
	Top expressed in
	placenta; ; ganglionic eminence; ; right adrenal cortex; ; left adrenal gland; ; left adrenal cortex; ; human kidney; ; endometrium; ; ventricular zone; ; islet of Langerhans; ; ovary;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; spermine synthase activity;
Cellular component	cytosol; extracellular exosome;
Biological process	spermine biosynthetic process; spermine metabolic process; polyamine biosynthetic process; methionine metabolic process; polyamine metabolic process;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	6611
	671878
	ENSG00000102172
	n/a
	P52788
	P97355
	NM_001258423; NM_004595
	XM_001473434
	NP_001245352; NP_004586
	NP_033240; NP_001346114
	Wikidata
View/Edit Human	View/Edit Mouse

SMS is a gene that encodes the enzyme spermine synthase in humans. The protein encoded by this gene belongs to the spermidine/spermine synthases family. This gene encodes a ubiquitous enzyme of polyamine metabolism.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000102172 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Korhonen VP, Halmekytö M, Kauppinen L, Myöhänen S, Wahlfors J, Keinänen T, et al. (October 1995). "Molecular cloning of a cDNA encoding human spermine synthase". DNA and Cell Biology. 14 (10): 841–847. doi:10.1089/dna.1995.14.841. PMID 7546290.
↑ Grieff M, Whyte MP, Thakker RV, Mazzarella R (September 1997). "Sequence analysis of 139 kb in Xp22.1 containing spermine synthase and the 5' region of PEX". Genomics. 44 (2): 227–231. doi:10.1006/geno.1997.4876. PMID 9299240.
1 2 "Entrez Gene: SMS spermine synthase".

Snyder RD, Robinson A (November 1969). "Recessive sex-linked mental retardation in the absence of other recognizable abnormalities. Report of a family". Clinical Pediatrics. 8 (11). Phila: 669–674. doi:10.1177/000992286900801114. PMID 5823961. S2CID 32198336.
Arena JF, Schwartz C, Ouzts L, Stevenson R, Miller M, Garza J, et al. (July 1996). "X-linked mental retardation with thin habitus, osteoporosis, and kyphoscoliosis: linkage to Xp21.3-p22.12". American Journal of Medical Genetics. 64 (1): 50–58. doi:10.1002/(SICI)1096-8628(19960712)64:1<50::AID-AJMG7>3.0.CO;2-V. PMID 8826448.
Sanger Centre T, Washington University Genome Sequencing Cente T (November 1998). "Toward a complete human genome sequence". Genome Research. 8 (11): 1097–1108. doi:10.1101/gr.8.11.1097. PMID 9847074.
Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, et al. (May 2003). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nature Biotechnology. 21 (5): 566–569. doi:10.1038/nbt810. PMID 12665801. S2CID 23783563.
Cason AL, Ikeguchi Y, Skinner C, Wood TC, Holden KR, Lubs HA, et al. (December 2003). "X-linked spermine synthase gene (SMS) defect: the first polyamine deficiency syndrome". European Journal of Human Genetics. 11 (12): 937–944. doi:10.1038/sj.ejhg.5201072. PMID 14508504.
Rush J, Moritz A, Lee KA, Guo A, Goss VL, Spek EJ, et al. (January 2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nature Biotechnology. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. S2CID 7200157.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000102172 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Korhonen_1995-4] Korhonen VP, Halmekytö M, Kauppinen L, Myöhänen S, Wahlfors J, Keinänen T, et al. (October 1995). "Molecular cloning of a cDNA encoding human spermine synthase". DNA and Cell Biology. 14 (10): 841–847. doi:10.1089/dna.1995.14.841. PMID 7546290.

[Grieff_1997-5] Grieff M, Whyte MP, Thakker RV, Mazzarella R (September 1997). "Sequence analysis of 139 kb in Xp22.1 containing spermine synthase and the 5' region of PEX". Genomics. 44 (2): 227–231. doi:10.1006/geno.1997.4876. PMID 9299240.

[entrez-6] 1 2 "Entrez Gene: SMS spermine synthase".

SMS (gene)

References

Further reading