Sorting nexin 10

SNX10
Identifiers
Aliases	SNX10, OPTB8, sorting nexin 10
External IDs	OMIM: 614780; MGI: 1919232; GeneCards: SNX10
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4ON3, 4PZG
Gene location (Human)
Chr.	Chromosome 7 (human)
End	26,374,383 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	51,590,679 bp
RNA expression pattern
	Top expressed in
	lateral nuclear group of thalamus; ; pars compacta; ; pars reticulata; ; pons; ; monocyte; ; superior vestibular nucleus; ; Brodmann area 23; ; dorsolateral prefrontal cortex; ; spinal ganglia; ; prefrontal cortex;
	Top expressed in
	granulocyte; ; dentate gyrus of hippocampal formation granule cell; ; facial motor nucleus; ; hippocampus proper; ; perirhinal cortex; ; temporal lobe; ; brown adipose tissue; ; piriform cortex; ; neural layer of retina; ; subiculum;
	More reference expression data
	n/a
Gene ontology
Molecular function	ATPase binding; 1-phosphatidylinositol binding; protein binding; phosphatidylinositol binding; lipid binding;
Cellular component	cytoplasm; endosome; centrosome; membrane; extrinsic component of endosome membrane; microtubule organizing center; endoplasmic reticulum; endosome membrane; cytoskeleton; nucleus; secretory granule; apical cytoplasm;
Biological process	endocytosis; osteoclast differentiation; endosome organization; cell projection organization; protein localization to cilium; protein transport; protein localization to centrosome; cilium assembly; cellular response to leukemia inhibitory factor; gastric acid secretion; bone mineralization; tooth eruption; bone resorption; calcium ion homeostasis; ruffle assembly;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	29887
	71982
	ENSG00000086300
	ENSMUSG00000038301
	Q9Y5X0; Q8N5Z3
	Q9CWT3
NM_001199835; NM_001199837; NM_001199838; NM_013322; NM_001318198;
	NM_001318199; NM_001362753; NM_001362754
	NM_001127348; NM_001127349; NM_028035
NP_001186764; NP_001186766; NP_001186767; NP_001305127; NP_001305128;
	NP_037454; NP_001349682; NP_001349683; NP_037454.2; NP_001305128.1
NP_001120820; NP_001120821; NP_082311; NP_001348505; NP_001348506;
	NP_001348507; NP_001348508; NP_001348509; NP_001348510; NP_001348511
	Wikidata
View/Edit Human	View/Edit Mouse

Sorting nexin 10 is a protein that in humans is encoded by the SNX10 gene.

Function

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members. This gene may play a role in regulating endosome homeostasis. Alternative splicing results in multiple transcript variants.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000086300 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000038301 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: Sorting nexin 10". Retrieved 2017-05-19.

Qin B, He M, Chen X, Pei D (2006). "Sorting nexin 10 induces giant vacuoles in mammalian cells". J. Biol. Chem. 281 (48): 36891–6. doi:10.1074/jbc.M608884200. PMID 17012226.
Chen Y, Wu B, Xu L, Li H, Xia J, Yin W, Li Z, Shi D, Li S, Lin S, Shu X, Pei D (2012). "A SNX10/V-ATPase pathway regulates ciliogenesis in vitro and in vivo". Cell Res. 22 (2): 333–45. doi:10.1038/cr.2011.134. PMC 3271581. PMID 21844891.
Zhu CH, Morse LR, Battaglino RA (2012). "SNX10 is required for osteoclast formation and resorption activity". J. Cell. Biochem. 113 (5): 1608–15. doi:10.1002/jcb.24029. PMID 22174188. S2CID 21535334.
Aker M, Rouvinski A, Hashavia S, Ta-Shma A, Shaag A, Zenvirt S, Israel S, Weintraub M, Taraboulos A, Bar-Shavit Z, Elpeleg O (2012). "An SNX10 mutation causes malignant osteopetrosis of infancy". J. Med. Genet. 49 (4): 221–6. doi:10.1136/jmedgenet-2011-100520. PMID 22499339.
Pangrazio A, Fasth A, Sbardellati A, Orchard PJ, Kasow KA, Raza J, Albayrak C, Albayrak D, Vanakker OM, De Moerloose B, Vellodi A, Notarangelo LD, Schlack C, Strauss G, Kühl JS, Caldana E, Lo Iacono N, Susani L, Kornak U, Schulz A, Vezzoni P, Villa A, Sobacchi C (2013). "SNX10 mutations define a subgroup of human autosomal recessive osteopetrosis with variable clinical severity". J. Bone Miner. Res. 28 (5): 1041–9. doi:10.1002/jbmr.1849. PMID 23280965. S2CID 23530205.
Xu J, Xu T, Wu B, Ye Y, You X, Shu X, Pei D, Liu J (2013). "Structure of sorting nexin 11 (SNX11) reveals a novel extended phox homology (PX) domain critical for inhibition of SNX10-induced vacuolation". J. Biol. Chem. 288 (23): 16598–605. doi:10.1074/jbc.M112.449306. PMC 3675595. PMID 23615901.
Xu T, Xu J, Ye Y, Wang Q, Shu X, Pei D, Liu J (2014). "Structure of human SNX10 reveals insights into its role in human autosomal recessive osteopetrosis". Proteins. 82 (12): 3483–9. doi:10.1002/prot.24689. PMID 25212774. S2CID 22007214.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 7 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000086300 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000038301 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Sorting nexin 10". Retrieved 2017-05-19.

Sorting nexin 10

Function

References

Further reading