SPDYA

SPDYA

Identifiers

SPDYA, RINGO3, RINGOA, SPDY1, SPY1, speedy/RINGO cell cycle regulator family member A

External IDs

OMIM: 614029; MGI: 1918141; GeneCards: SPDYA

Gene location (Human)

Chr.	Chromosome 2 (human)

Band	2p23.2	Start	28,782,517 bp
Band	2p23.2	End	28,850,611 bp

Gene location (Mouse)

Chr.	Chromosome 17 (mouse)

Band	17\|17 E1.3	Start	71,859,056 bp
Band	17\|17 E1.3	End	71,896,528 bp

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

left testis

right testis

sperm

testicle

Achilles tendon

gonad

left ovary

granulocyte

right ovary

mucosa of transverse colon

Top expressed in

spermatocyte

spermatid

seminiferous tubule

Stroma of ovary

ooblast

lumbar subsegment of spinal cord

morula

embryo

tail of embryo

ventricular zone

More reference expression data

n/a

Gene ontology
Molecular function	protein kinase binding protein kinase activator activity
Cellular component	nucleus nucleoplasm
Biological process	multicellular organism development cell cycle positive regulation of cyclin-dependent protein serine/threonine kinase activity male meiotic nuclear division positive regulation of cell population proliferation cellular response to DNA damage stimulus activation of protein kinase activity positive regulation of protein kinase activity G1/S transition of mitotic cell cycle
Sources:Amigo / QuickGO

Databases

NCBI: entry; OMA: entry

Species

Human

Mouse


245711


70891


ENSG00000163806


ENSMUSG00000052525


Q5MJ70


Q5IBH7

RefSeq (mRNA)


NM_182756 NM_001008779 NM_001142634


NM_001142631 NM_029254

RefSeq (protein)


NP_001008779 NP_001136106 NP_877433


NP_001136103 NP_083530

Location (UCSC)

Chr 2: 28.78 – 28.85 Mb

Chr 17: 71.86 – 71.9 Mb

PubMed search

View/Edit Human

View/Edit Mouse

Speedy protein A is a protein that in humans is encoded by the SPDYA gene.

Interactions

SPDYA has been shown to interact with CDKN1B.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000163806 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000052525 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Porter LA, Dellinger RW, Tynan JA, Barnes EA, Kong M, Lenormand JL, Donoghue DJ (Apr 2002). "Human Speedy: a novel cell cycle regulator that enhances proliferation through activation of Cdk2". The Journal of Cell Biology. 157 (3): 357–66. doi:10.1083/jcb.200109045. PMC 2173287. PMID 11980914.
↑ Barnes EA, Porter LA, Lenormand JL, Dellinger RW, Donoghue DJ (Jul 2003). "Human Spy1 promotes survival of mammalian cells following DNA damage". Cancer Research. 63 (13): 3701–7. PMID 12839962.
↑ Cheng A, Xiong W, Ferrell JE, Solomon MJ (Jan 2005). "Identification and comparative analysis of multiple mammalian Speedy/Ringo proteins". Cell Cycle. 4 (1): 155–65. doi:10.4161/cc.4.1.1347. PMID 15611625.
↑ "Entrez Gene: SPDYA speedy homolog A (Drosophila)".
↑ Porter LA, Kong-Beltran M, Donoghue DJ (Sep 2003). "Spy1 interacts with p27Kip1 to allow G1/S progression". Molecular Biology of the Cell. 14 (9): 3664–74. doi:10.1091/mbc.E02-12-0820. PMC 196558. PMID 12972555.

Further reading

Porter LA, Kong-Beltran M, Donoghue DJ (Sep 2003). "Spy1 interacts with p27Kip1 to allow G1/S progression". Molecular Biology of the Cell. 14 (9): 3664–74. doi:10.1091/mbc.E02-12-0820. PMC 196558. PMID 12972555.
Gastwirt RF, Slavin DA, McAndrew CW, Donoghue DJ (Nov 2006). "Spy1 expression prevents normal cellular responses to DNA damage: inhibition of apoptosis and checkpoint activation". The Journal of Biological Chemistry. 281 (46): 35425–35. doi:10.1074/jbc.M604720200. PMID 16951407.
McAndrew CW, Gastwirt RF, Meyer AN, Porter LA, Donoghue DJ (Aug 2007). "Spy1 enhances phosphorylation and degradation of the cell cycle inhibitor p27". Cell Cycle. 6 (15): 1937–45. doi:10.4161/cc.6.15.4520. PMID 17671428.

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