SPINK6

SPINK6
Identifiers
Aliases	SPINK6, BUSI2, UNQ844, serine peptidase inhibitor, Kazal type 6, serine peptidase inhibitor Kazal type 6
External IDs	OMIM: 615868; MGI: 3648654; GeneCards: SPINK6
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2N52
Gene location (Human)
Chr.	Chromosome 5 (human)
End	148,215,137 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	44,216,678 bp
RNA expression pattern
	Top expressed in
	testicle; ; right hemisphere of cerebellum; ; minor salivary glands; ; gonad; ; vagina; ; corpus callosum; ; right adrenal cortex; ; muscle layer of sigmoid colon; ; skin of leg; ; left coronary artery;
	Top expressed in
	lip; ; embryo; ; embryo; ; zone of skin; ; renal cortex; ; muscle of thigh; ; human kidney; ; liver;
	More reference expression data
	n/a
Gene ontology
Molecular function	peptidase inhibitor activity; serine-type endopeptidase inhibitor activity;
Cellular component	extracellular region;
Biological process	negative regulation of peptidase activity; cornification; negative regulation of serine-type endopeptidase activity;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	404203
	433180
	ENSG00000178172
	ENSMUSG00000055095
	Q6UWN8
	Q8BT20
	NM_205841; NM_001195290
	NM_001013797; NM_001357563; NM_001357564
	NP_001182219; NP_995313
	NP_001013819; NP_001344492; NP_001344493
	Wikidata
View/Edit Human	View/Edit Mouse

Serine protease inhibitor Kazal-type 6 (SPINK6) is a protein encoded by the SPINK6 gene in humans. It is a potent inhibitor of epidermal proteases involved in maintaining skin homeostasis, including KLK5, KLK7 and KLK14. SPINK6 is a member of a gene family cluster located on chromosome 5q33.1, which includes SPINK5 and SPINK9.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000178172 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000055095 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Meyer-Hoffert U; Wu Z; Kantyka T; Fischer J; Latendorf T; Hansmann B; Bartels J; He Y; Gläser R; Schröder JM. (October 2010). "Isolation of SPINK6 in human skin: selective inhibitor of kallikrein-related peptidases". J Biol Chem. 285 (42): 32174–81. doi:10.1074/jbc.M109.091850. PMC 2952218. PMID 20667819.
↑ Furio L; Hovnanian A. (November 2011). "When Activity Requires Breaking Up: LEKTI Proteolytic Activation Cascade for Specific Proteinase Inhibition". J Invest Dermatol. 131 (11): 2169–73. doi:10.1038/jid.2011.295. PMID 21997416.

This article on a gene on human chromosome 5 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000178172 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000055095 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[meyer-5] Meyer-Hoffert U; Wu Z; Kantyka T; Fischer J; Latendorf T; Hansmann B; Bartels J; He Y; Gläser R; Schröder JM. (October 2010). "Isolation of SPINK6 in human skin: selective inhibitor of kallikrein-related peptidases". J Biol Chem. 285 (42): 32174–81. doi:10.1074/jbc.M109.091850. PMC 2952218. PMID 20667819.

[furio-6] Furio L; Hovnanian A. (November 2011). "When Activity Requires Breaking Up: LEKTI Proteolytic Activation Cascade for Specific Proteinase Inhibition". J Invest Dermatol. 131 (11): 2169–73. doi:10.1038/jid.2011.295. PMID 21997416.

SPINK6

See also

References