SPIRE1

SPIRE1
Identifiers
Aliases	SPIRE1, Spir-1, spire type actin nucleation factor 1
External IDs	OMIM: 609216; MGI: 1915416; GeneCards: SPIRE1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2YLE, 2YLF, 3R7G, 3RBW
Gene location (Human)
Chr.	Chromosome 18 (human)
End	12,658,107 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	67,610,790 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; internal globus pallidus; ; endothelial cell; ; pancreatic epithelial cell; ; ventricular zone; ; myocardium of left ventricle; ; Achilles tendon; ; cardiac muscle tissue of right atrium; ; postcentral gyrus; ; pancreatic ductal cell;
	Top expressed in
	secondary oocyte; ; primary oocyte; ; zygote; ; visual cortex; ; primary visual cortex; ; superior frontal gyrus; ; ventricular zone; ; cerebellar cortex; ; otolith organ; ; utricle;
	More reference expression data
	n/a
Gene ontology
Molecular function	actin binding;
Cellular component	cytoplasm; perinuclear region of cytoplasm; plasma membrane; cell cortex; cleavage furrow; cytoskeleton; cytoplasmic vesicle membrane; membrane; cytoplasmic vesicle; nucleoplasm; cytosol;
Biological process	protein transport; establishment of meiotic spindle localization; actin nucleation; intracellular transport; formin-nucleated actin cable assembly; polar body extrusion after meiotic divisions; cleavage furrow formation; vesicle-mediated transport; actin cytoskeleton organization; positive regulation of double-strand break repair;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	56907
	68166
	ENSG00000134278
	ENSMUSG00000024533
	Q08AE8
	Q52KF3
NM_001128626; NM_001128627; NM_020148; NM_001394323; NM_001394324;
	NM_001394325
	NM_176832; NM_194355
	NP_001122098; NP_001122099; NP_064533
	NP_789802; NP_919336; NP_001390588; NP_001390589; NP_001390590
	Wikidata
View/Edit Human	View/Edit Mouse

Protein spire homolog 1 is a protein that in humans is encoded by the SPIRE1 gene. SPIRE1 interacts with actin monomers and actin nucleating formin proteins. SPIRE1 was first identified in Drosophila melanogaster. SPIRE1 contains an N-terminal KIND domain which binds formins and four actin-binding WH2 domains which nucleate actin filaments.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000134278 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024533 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "SPIRE1 - Protein spire homolog 1 - Homo sapiens (Human) - SPIRE1 gene & protein". UniProt.
↑ Manseau LJ, Schüpbach T (September 1989). "cappuccino and spire: two unique maternal-effect loci required for both the anteroposterior and dorsoventral patterns of the Drosophila embryo". Genes & Development. 3 (9): 1437–1452. doi:10.1101/gad.3.9.1437. PMID 2514120.
↑ Quinlan ME, Heuser JE, Kerkhoff E, Mullins RD (January 2005). "Drosophila Spire is an actin nucleation factor". Nature. 433 (7024): 382–388. Bibcode:2005Natur.433..382Q. doi:10.1038/nature03241. PMID 15674283. S2CID 4424757.
↑ Vizcarra CL, Kreutz B, Rodal AA, Toms AV, Lu J, Zheng W, et al. (July 2011). "Structure and function of the interacting domains of Spire and Fmn-family formins". Proceedings of the National Academy of Sciences of the United States of America. 108 (29): 11884–11889. Bibcode:2011PNAS..10811884V. doi:10.1073/pnas.1105703108. PMC 3141961. PMID 21730168.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000134278 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024533 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] "SPIRE1 - Protein spire homolog 1 - Homo sapiens (Human) - SPIRE1 gene & protein". UniProt.

[6] Manseau LJ, Schüpbach T (September 1989). "cappuccino and spire: two unique maternal-effect loci required for both the anteroposterior and dorsoventral patterns of the Drosophila embryo". Genes & Development. 3 (9): 1437–1452. doi:10.1101/gad.3.9.1437. PMID 2514120.

[7] Quinlan ME, Heuser JE, Kerkhoff E, Mullins RD (January 2005). "Drosophila Spire is an actin nucleation factor". Nature. 433 (7024): 382–388. Bibcode:2005Natur.433..382Q. doi:10.1038/nature03241. PMID 15674283. S2CID 4424757.

[8] Vizcarra CL, Kreutz B, Rodal AA, Toms AV, Lu J, Zheng W, et al. (July 2011). "Structure and function of the interacting domains of Spire and Fmn-family formins". Proceedings of the National Academy of Sciences of the United States of America. 108 (29): 11884–11889. Bibcode:2011PNAS..10811884V. doi:10.1073/pnas.1105703108. PMC 3141961. PMID 21730168.