Snurportin-1 Protein found in humans
Snurportin-1 is a protein that in humans is encoded by the SNUPN gene (also written SPN1 ).
The nuclear import of the spliceosomal snRNPs U1, U2, U4 and U5 is dependent on the presence of a complex nuclear localization signal. The latter is composed of the 5'-2,2,7-terminal trimethylguanosine (m3G) cap structure of the U snRNA and the Sm core domain. The protein encoded by this gene interacts specifically with m3G-cap and functions as an snRNP-specific nuclear import receptor. Alternatively spliced transcript variants encoding the same protein have been identified for this gene.
References
1 2 3 GRCh38: Ensembl release 89: ENSG00000169371 – Ensembl , May 20171 2 3 GRCm38: Ensembl release 89: ENSMUSG00000055334 – Ensembl , May 2017↑ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .↑ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .↑ Huber J, Cronshagen U, Kadokura M, Marshallsay C, Wada T, Sekine M, Luhrmann R (Sep 1998). "Snurportin1, an m3G-cap-specific nuclear import receptor with a novel domain structure" . EMBO J . 17 (14): 4114– 26. doi :10.1093/emboj/17.14.4114 . PMC 1170744 PMID 9670026 . 1 2 "Entrez Gene: SNUPN snurportin 1" .
Further reading
Paraskeva E, Izaurralde E, Bischoff FR, et al. (1999). "CRM1-mediated recycling of snurportin 1 to the cytoplasm" . J. Cell Biol . 145 (2): 255– 64. doi :10.1083/jcb.145.2.255 . PMC 2133107 PMID 10209022 . Narayanan U, Ospina JK, Frey MR, et al. (2003). "SMN, the spinal muscular atrophy protein, forms a pre-import snRNP complex with snurportin1 and importin beta" . Hum. Mol. Genet . 11 (15): 1785– 95. doi :10.1093/hmg/11.15.1785 . PMC 1630493 PMID 12095920 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899– 903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40– 5. doi :10.1038/ng1285 PMID 14702039 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121– 7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Strasser A, Dickmanns A, Lührmann R, Ficner R (2005). "Structural basis for m3G-cap-mediated nuclear import of spliceosomal UsnRNPs by snurportin1" . EMBO J . 24 (13): 2235– 43. doi :10.1038/sj.emboj.7600701 . PMC 1173142 PMID 15920472 . Ospina JK, Gonsalvez GB, Bednenko J, et al. (2006). "Cross-talk between snurportin1 subdomains" . Mol. Biol. Cell . 16 (10): 4660– 71. doi :10.1091/mbc.E05-04-0316 . PMC 1237072 PMID 16030253 . Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell . 122 (6): 957– 68. doi :10.1016/j.cell.2005.08.029 . hdl :11858/00-001M-0000-0010-8592-0 PMID 16169070 . S2CID 8235923 .
