SPNS2

SPNS2
Identifiers
Aliases	SPNS2, sphingolipid transporter 2, SLC62A2, DFNB115, SLC63A2
External IDs	OMIM: 612584; MGI: 2384936; GeneCards: SPNS2
Gene location (Human)
Chr.	Chromosome 17 (human)
End	4,539,035 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	72,380,730 bp
RNA expression pattern
	Top expressed in
	mucosa of pharynx; ; C1 segment; ; skin of arm; ; buccal mucosa cell; ; renal medulla; ; right lung; ; inferior ganglion of vagus nerve; ; right frontal lobe; ; upper lobe of left lung; ; Brodmann area 9;
	Top expressed in
	esophagus; ; lip; ; muscle of thigh; ; triceps brachii muscle; ; gastrocnemius muscle; ; sternocleidomastoid muscle; ; temporal muscle; ; knee joint; ; mesenteric lymph nodes; ; medial head of gastrocnemius muscle;
	More reference expression data
	n/a
Gene ontology
Molecular function	sphingolipid transporter activity;
Cellular component	integral component of membrane; vesicle; lysosomal membrane; membrane;
Biological process	lymphocyte homeostasis; regulation of humoral immune response; regulation of eye pigmentation; lipid transport; lymph node development; B cell homeostasis; bone development; lymphocyte migration; locomotion; transmembrane transport; sphingosine-1-phosphate receptor signaling pathway; sphingolipid metabolic process; T cell homeostasis;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	124976
	216892
	ENSG00000183018
	ENSMUSG00000040447
	Q8IVW8
	Q91VM4
	NM_001124758
	NM_001276383; NM_153060
	NP_001118230
	NP_001263312; NP_694700
	Wikidata
View/Edit Human	View/Edit Mouse

Spinster homolog 2 (Drosophila) is a protein that in humans is encoded by the SPNS2 gene.

Model organisms

The orthologous protein in zebrafish has been shown to transport sphingosine-1-phosphate (S1P) out of cells during vascular development, and human SPNS2 can transport S1P analogues, including the immunomodulating drug FTY720-P.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000183018 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000040447 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Spinster homolog 2 (Drosophila)". Retrieved 2011-12-04.
↑ Kawahara A, Nishi T, Hisano Y, Fukui H, Yamaguchi A, Mochizuki N (January 2009). "The sphingolipid transporter spns2 functions in migration of zebrafish myocardial precursors". Science. 323 (5913): 524–7. Bibcode:2009Sci...323..524K. doi:10.1126/science.1167449. PMID 19074308. S2CID 44826764.
↑ Hisano Y, Kobayashi N, Kawahara A, Yamaguchi A, Nishi T (January 2011). "The sphingosine 1-phosphate transporter, SPNS2, functions as a transporter of the phosphorylated form of the immunomodulating agent FTY720". The Journal of Biological Chemistry. 286 (3): 1758–66. doi:10.1074/jbc.M110.171116. PMC 3023470. PMID 21084291.

This article on a gene on human chromosome 17 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000183018 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000040447 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Spinster homolog 2 (Drosophila)". Retrieved 2011-12-04.

[6] Kawahara A, Nishi T, Hisano Y, Fukui H, Yamaguchi A, Mochizuki N (January 2009). "The sphingolipid transporter spns2 functions in migration of zebrafish myocardial precursors". Science. 323 (5913): 524–7. Bibcode:2009Sci...323..524K. doi:10.1126/science.1167449. PMID 19074308. S2CID 44826764.

[7] Hisano Y, Kobayashi N, Kawahara A, Yamaguchi A, Nishi T (January 2011). "The sphingosine 1-phosphate transporter, SPNS2, functions as a transporter of the phosphorylated form of the immunomodulating agent FTY720". The Journal of Biological Chemistry. 286 (3): 1758–66. doi:10.1074/jbc.M110.171116. PMC 3023470. PMID 21084291.