SPRED2

SPRED2

Identifiers

SPRED2, Spred-2, sprouty related EVH1 domain containing 2, NS14

External IDs

OMIM: 609292; MGI: 2150019; GeneCards: SPRED2

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2JP2

Gene location (Human)

Chr.	Chromosome 2 (human)

Band	2p14	Start	65,310,851 bp
Band	2p14	End	65,432,637 bp

Gene location (Mouse)

Chr.	Chromosome 11 (mouse)

Band	11\|11 A3.1	Start	19,874,375 bp
Band	11\|11 A3.1	End	19,974,026 bp

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

sural nerve

mucosa of sigmoid colon

ventricular zone

cartilage tissue

epithelium of colon

gonad

postcentral gyrus

prefrontal cortex

superior frontal gyrus

Brodmann area 46

Top expressed in

tail of embryo

primitive streak

prefrontal cortex

cingulate gyrus

genital tubercle

hair follicle

primary motor cortex

hippocampus proper

cerebellar vermis

lobe of cerebellum

More reference expression data


More reference expression data

Gene ontology
Molecular function	protein binding protein kinase binding protein serine/threonine kinase inhibitor activity stem cell factor receptor binding
Cellular component	cytoplasm plasma membrane transport vesicle membrane membrane cytoplasmic vesicle cytosol
Biological process	multicellular organism development negative regulation of peptidyl-threonine phosphorylation regulation of signal transduction fibroblast growth factor receptor signaling pathway regulation of protein deacetylation positive regulation of DNA damage response, signal transduction by p53 class mediator
Sources:Amigo / QuickGO

Databases

NCBI: entry; OMA: entry

Species

Human

Mouse


200734


114716


ENSG00000198369


ENSMUSG00000045671


Q7Z698


Q924S7

RefSeq (mRNA)


NM_001128210 NM_181784


NM_033523

RefSeq (protein)


NP_001121682 NP_861449


NP_277058

Location (UCSC)

Chr 2: 65.31 – 65.43 Mb

Chr 11: 19.87 – 19.97 Mb

PubMed search

View/Edit Human

View/Edit Mouse

Sprouty-related, EVH1 domain-containing protein 2 is a protein that in humans is encoded by the SPRED2 gene.

Function

SPRED2 is a member of the Sprouty (see SPRY1)/SPRED family of proteins that regulate growth factor-induced activation of the MAP kinase cascade (see MAPK1).

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000198369 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000045671 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 "Entrez Gene: SPRED2 sprouty-related, EVH1 domain containing 2".

Further reading

Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
Wakioka T, Sasaki A, Kato R, et al. (2001). "Spred is a Sprouty-related suppressor of Ras signalling". Nature. 412 (6847): 647–51. Bibcode:2001Natur.412..647W. doi:10.1038/35088082. PMID 11493923. S2CID 4345140.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Kato R, Nonami A, Taketomi T, et al. (2003). "Molecular cloning of mammalian Spred-3 which suppresses tyrosine kinase-mediated Erk activation". Biochem. Biophys. Res. Commun. 302 (4): 767–72. doi:10.1016/S0006-291X(03)00259-6. PMID 12646235.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Nobuhisa I, Kato R, Inoue H, et al. (2004). "Spred-2 suppresses aorta-gonad-mesonephros hematopoiesis by inhibiting MAP kinase activation". J. Exp. Med. 199 (5): 737–42. doi:10.1084/jem.20030830. PMC 2213301. PMID 14981116.
Miyoshi K, Wakioka T, Nishinakamura H, et al. (2004). "The Sprouty-related protein, Spred, inhibits cell motility, metastasis, and Rho-mediated actin reorganization". Oncogene. 23 (33): 5567–76. doi:10.1038/sj.onc.1207759. PMID 15184877.
Zimmermann J, Jarchau T, Walter U, et al. (2005). "1H, 13C and 15N resonance assignment of the human Spred2 EVH1 domain". J. Biomol. NMR. 29 (3): 435–6. doi:10.1023/B:JNMR.0000032526.17586.8c. PMID 15213456. S2CID 37933714.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Engelhardt CM, Bundschu K, Messerschmitt M, et al. (2005). "Expression and subcellular localization of Spred proteins in mouse and human tissues". Histochem. Cell Biol. 122 (6): 527–38. doi:10.1007/s00418-004-0725-6. PMID 15580519. S2CID 24496085.
King JA, Straffon AF, D'Abaco GM, et al. (2005). "Distinct requirements for the Sprouty domain for functional activity of Spred proteins". Biochem. J. 388 (Pt 2): 445–54. doi:10.1042/BJ20041284. PMC 1138951. PMID 15683364.
Bundschu K, Knobeloch KP, Ullrich M, et al. (2005). "Gene disruption of Spred-2 causes dwarfism". J. Biol. Chem. 280 (31): 28572–80. doi:10.1074/jbc.M503640200. PMID 15946934.
Yoshida T, Hisamoto T, Akiba J, et al. (2006). "Spreds, inhibitors of the Ras/ERK signal transduction, are dysregulated in human hepatocellular carcinoma and linked to the malignant phenotype of tumors". Oncogene. 25 (45): 6056–66. doi:10.1038/sj.onc.1209635. PMID 16652141.
Lock P, I ST, Straffon AF, et al. (2007). "Spred-2 steady-state levels are regulated by phosphorylation and Cbl-mediated ubiquitination". Biochem. Biophys. Res. Commun. 351 (4): 1018–23. doi:10.1016/j.bbrc.2006.10.150. PMID 17094949.

External links

GeneReviews/NIH/NCBI/UW entry on Legius syndrome SPRED1 Sprouty-related, EVH1 domain-containing protein 1

v t e PDB gallery
2jp2: Solution structure and resonance assignment of the N-terminal EVH1 domain from the human Spred2 protein (Sprouty-related protein with EVH1 domain isoform 2)

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