SPRY4

SPRY4
Identifiers
Aliases	SPRY4, HH17, sprouty RTK signaling antagonist 4
External IDs	OMIM: 607984; MGI: 1345144; GeneCards: SPRY4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3BUN
Gene location (Human)
Chr.	Chromosome 5 (human)
End	142,326,455 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	38,734,468 bp
RNA expression pattern
	Top expressed in
	left coronary artery; ; right lung; ; ascending aorta; ; upper lobe of left lung; ; Descending thoracic aorta; ; cartilage tissue; ; right coronary artery; ; lower lobe of lung; ; tibial arteries; ; left adrenal gland;
	Top expressed in
	secondary oocyte; ; primary oocyte; ; tail of embryo; ; zygote; ; left lung lobe; ; lumbar spinal ganglion; ; entorhinal cortex; ; perirhinal cortex; ; Ileal epithelium; ; nasolacrimal duct;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding;
Cellular component	ruffle membrane; plasma membrane; cell projection; membrane; focal adhesion; cytoplasm; cytosol;
Biological process	multicellular organism development; negative regulation of ERK1 and ERK2 cascade; regulation of signal transduction; negative regulation of fibroblast growth factor receptor signaling pathway; negative regulation of MAP kinase activity; negative regulation of Ras protein signal transduction;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	81848
	24066
	ENSG00000187678
	ENSMUSG00000024427
	Q9C004
	Q9WTP2
	NM_001127496; NM_001293289; NM_001293290; NM_030964
	NM_011898
	NP_001120968; NP_001280218; NP_001280219; NP_112226
	NP_036028
	Wikidata
View/Edit Human	View/Edit Mouse

Protein sprouty homolog 4 is a protein that in humans is encoded by the SPRY4 gene.

Function

SPRY4 is an inhibitor of the receptor-transduced mitogen-activated protein kinase (MAPK) signaling pathway. It is positioned upstream of RAS (see HRAS; MIM 190020) activation and impairs the formation of active GTP-RAS (Leeksma et al., 2002).

Interactions

SPRY4 has been shown to interact with TESK1.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000187678 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024427 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Katoh Y, Katoh M (Mar 2006). "FGF signaling inhibitor, SPRY4, is evolutionarily conserved target of WNT signaling pathway in progenitor cells". International Journal of Molecular Medicine. 17 (3): 529–32. doi:10.3892/ijmm.17.3.529. PMID 16465403.
1 2 "Entrez Gene: SPRY4 sprouty homolog 4 (Drosophila)".
↑ Leeksma OC, Van Achterberg TA, Tsumura Y, Toshima J, Eldering E, Kroes WG, Mellink C, Spaargaren M, Mizuno K, Pannekoek H, de Vries CJ (May 2002). "Human sprouty 4, a new ras antagonist on 5q31, interacts with the dual specificity kinase TESK1". European Journal of Biochemistry. 269 (10): 2546–56. doi:10.1046/j.1432-1033.2002.02921.x. PMID 12027893.

External links

PDBe-KB provides an overview of all the structure information available in the PDB for Human Protein sprouty homolog 4 (SPRY4)

This article on a gene on human chromosome 5 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000187678 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024427 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid16465403-5] Katoh Y, Katoh M (Mar 2006). "FGF signaling inhibitor, SPRY4, is evolutionarily conserved target of WNT signaling pathway in progenitor cells". International Journal of Molecular Medicine. 17 (3): 529–32. doi:10.3892/ijmm.17.3.529. PMID 16465403.

[entrez-6] 1 2 "Entrez Gene: SPRY4 sprouty homolog 4 (Drosophila)".

[pmid12027893-7] Leeksma OC, Van Achterberg TA, Tsumura Y, Toshima J, Eldering E, Kroes WG, Mellink C, Spaargaren M, Mizuno K, Pannekoek H, de Vries CJ (May 2002). "Human sprouty 4, a new ras antagonist on 5q31, interacts with the dual specificity kinase TESK1". European Journal of Biochemistry. 269 (10): 2546–56. doi:10.1046/j.1432-1033.2002.02921.x. PMID 12027893.

SPRY4

Function

Interactions

See also

References

Further reading

External links